Multifunctional Magnetized Porous Silica Covered with Poly(2-dimethylaminoethyl methacrylate) for pH Controllable Drug Release and Magnetic Resonance Imaging

2018 ◽  
Vol 1 (9) ◽  
pp. 5027-5034 ◽  
Author(s):  
Ling Li ◽  
Cheng Zhang ◽  
Run Zhang ◽  
Zushun Xu ◽  
Zhiping Xu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Porous Silica ◽  
Resonance Imaging ◽  
Dimethylaminoethyl Methacrylate

scholarly journals Eccentric magnetic microcapsules for MRI-guided local administration and pH-regulated drug release

RSC Advances ◽  
2018 ◽  
Vol 8 (73) ◽  
pp. 41956-41965
Author(s):  
Jingxian Huang ◽  
Wenwei Huang ◽  
Yin Chen ◽  
Yu Shrike Zhang ◽  
Jinshuang Zhong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Local Administration ◽  
Resonance Imaging ◽  
Mri Guided

Uniform eccentric magnetic microcapsules for magnetic resonance imaging-guided local administration and pH-regulated drug release were developed.

Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform

2020 ◽  
Vol 56 (71) ◽  
pp. 10297-10300
Author(s):  
Chi-An Cheng ◽  
Wei Chen ◽  
Le Zhang ◽  
Holden H. Wu ◽  
Jeffrey I. Zink
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Core Shell ◽  
Resonance Imaging

A self-reporting theranostic approach that controls and “images” drug release from nanoparticles using magnetic resonance imaging-guided high-intensity focused ultrasound is presented.

The use of magnetic resonance imaging to track controlled drug release and transport in the brain

1993 ◽  
Vol 11 (2) ◽  
pp. 247-252 ◽  
Author(s):  
Bradley Reisfeld ◽  
Stephen Blackband ◽  
Vince Calhoun ◽  
Stuart Grossman ◽  
Susan Eller ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Resonance Imaging ◽  
The Brain

scholarly journals Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release

2018 ◽  
Vol 2018 ◽  
pp. 1-14
Author(s):  
Rui Zhang ◽  
Benjamin Fellows ◽  
Nikorn Pothayee ◽  
Nan Hu ◽  
Nipon Pothayee ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Aqueous Media ◽  
Potential Drug ◽  
Resonance Imaging ◽  
Temperature Dependent ◽  
Hyperthermia Treatment

Novel magnetite-ammonium bisphosphonate graft ionic copolymer nanocomplexes (MGICs) have been developed for potential drug delivery, magnetic resonance imaging, and hyperthermia applications. The complexes displayed relatively uniform sizes with narrow size distributions upon self-assembly in aqueous media, and their sizes were stable under simulated physiological conditions for at least 7 days. The anticancer drugs, cisplatin and carboplatin, were loaded into the complexes, and sustained release of both drugs was observed. The transverse NMR relaxivities (r2s) of the complexes were 244 s−1 (mM Fe)−1 which is fast compared to either the commercial T2-weighted MRI agent Feridex IV® or our previously reported magnetite-block ionomer complexes. Phantom MRI images of the complexes demonstrated excellent negative contrast effects of such complexes. Thus, the bisphosphonate-bearing MGICs could be promising candidates for dual drug delivery and magnetic resonance imaging. Moreover, the bisphosphonate MGICs generate heat under an alternating magnetic field of 30 kA·m−1 at 206 kHz. The temperature of the MGIC dispersion in deionized water increased from 37 to 41°C after exposure to the magnetic field for 10 minutes, corresponding to a specific absorption rate of 77.0 W·g−1. This suggests their potential as hyperthermia treatment agents as well as the possibility of temperature-dependent drug release, making MGICs more versatile in potential drug delivery applications.

scholarly journals Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging.

1995 ◽  
Vol 39 (4) ◽  
pp. 839-845 ◽  
Author(s):  
R Weissleder ◽  
K Poss ◽  
R Wilkinson ◽  
C Zhou ◽  
A Bogdanov
Keyword(s):  
Magnetic Resonance Imaging ◽  
Polyethylene Glycol ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Lethal Dose ◽  
Dimensional Structure ◽  
Therapeutic Drug ◽  
Resonance Imaging ◽  
Drug Concentrations

A biodegradable model hydrogel containing a covalently bound aminoglycoside in which drug release can be monitored by magnetic resonance imaging (MRI) in vivo was developed. The hydrogel consists of the bishydroxysuccinimide ester of polyethylene glycol disuccinate cross-linked albumin, to which gentamicin and Gd-diethylenetriaminepentaacetic acid are covalently attached in stochiometric quantities. MRI allowed us to depict the three-dimensional structure of implanted gels, to accurately calculate their volumes, and thus to calculate the concentration of hydrogel-bound gentamicin. The correlation coefficient for the concentration of released gentamicin and the hydrogel volume was 0.965. Free and hydrogel-released gentamicin conjugates had similar antibiotic efficacies when tested in microbiological agar diffusion assays. In vivo, hydrogel-released gentamicin had a longer half-life in plasma than unaltered gentamicin (5.6 versus 0.7 h), presumably because of residual bound polyethylene glycol residues. Hydrogel implants into rats resulted in a prolonged (7 to 10 days) release of gentamicin and a decreased 24-h mortality in mice infected with a lethal dose of Pseudomonas aeruginosa. The results indicate the feasibility of imaging and quantitating therapeutic drug concentrations in vivo by MRI.

scholarly journals Towards an image-guided restricted drug release in friendly implanted therapeutics

2018 ◽  
Vol 82 (3) ◽  
pp. 31401
Author(s):  
Adel Razek
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Minimally Invasive ◽  
Electromagnetic Compatibility ◽  
Resonance Imaging ◽  
Mr Image ◽  
Image Guided ◽  
Compatibility Analysis ◽  
Position Detection

This review aims to expose a possible therapeutics scheme of using active implants for restricted drug release accounting for friendly wellbeing and security of patient. The review of embedded therapeutics, regulated drug administration, minimally-invasive issues and governing non-ionizing position detection suggested a possible MR image-guided approach. The magnetic resonance imaging is then investigated and its environmental compatibility is explored through electromagnetic compatibility analysis for embedded therapeutics.

Multifunctional theranostic nanosystems enabling photothermal-chemo combination therapy of triple-stimuli-responsive drug release with magnetic resonance imaging

2020 ◽  
Vol 8 (7) ◽  
pp. 1875-1884 ◽  
Author(s):  
Xiao Lin ◽  
Xiaofang Song ◽  
Yiwei Zhang ◽  
Yanbing Cao ◽  
Yanan Xue ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Combination Therapy ◽  
Thermal Imaging ◽  
Stimuli Responsive ◽  
Resonance Imaging

As a multifunctional theranostic nanoplatform, FPCH-DOX NPs enable triple-stimuli responsive drug release for MR/thermal imaging-guided photothermal-chemo combination therapy.

scholarly journals Novel Multifunctional Magnetic Nanoparticles：An Efficient Theranostic Platform for Magnetic Resonance Imaging and Targeted Therapy of Cervical Cancer

2021 ◽  
Author(s):  
Shu Yao ◽  
Li Li ◽  
Chang Liu ◽  
Ziying Wang ◽  
Hong Liu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Field ◽  
Cervical Cancer ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Tumor Targeting ◽  
Resonance Imaging ◽  
Tumor Killing

Abstract Background: The high incidence and mortality rates of cervical cancer pose a serious threat to women's health. Traditional chemotherapy has inevitable drawbacks of nonspecific tumor targeting, high toxicity, and poor therapeutic efficiency. In order to overcome these shortcomings, a novel multifunctional magnetic nanoparticles drug delivery system with tumor targeting and magnetic resonance imaging was developed to achieve precise diagnosis and targeted tumor killing effects.Methods: Transmission electron microscopy, dynamic light scatting and ultraviolet methods were used to characterize the nanoparticles in vitro. Cell function tests were performed by scratch, transwell and flow cytometry assays. MTT was used to detect the toxicity of the nanoparticles. The motion trajectory, drug release and uptake studies were carried out in vitro. The in vivo pharmacokinetic and drug distribution studies were verified by high performance liquid chromatography methods. Attenuation of the MRI signal by the nanoparticles and their enhanced antitumor efficiency were examined in vivo in mouse cervical cancer models. Sequencing and proteomics were used to detect the key antitumor molecules of the nanoparticles.Results: Multifunctional magnetic nanoparticles coated with ferric oxide nanoparticles and doxorubicin hydrochloride (DOX-Fe3O4-PEG-PLA-NPs) was prepared successfully. No toxicity was detected of PEG-PLA-NP, however, the tumor killing effect was enhanced under the alternating magnetic field significantly. The drug-release study showed that the cumulative release rates of NP groups were much less than free DOX group, while the drug release rate increased under acidic condition. In addition, DOX-Fe3O4-PEG-PLA-NPs showed improved internalized into carcinoma cells under magnetic field significantly. In vivo studies demonstrated that the combined therapy under an alternating magnetic field displayed improved therapeutic effect when compared with individual therapies as documented by the delayed tumor growth, inhibition of metastasis, and prolonged survival. The in vitro and in vivo MRI results showed that the multifunctional magnetic nanomaterial had a better MRI signal reduction effect and a higher T2 relaxation rate.Conclusions: We developed an cervical cancer targeting nano-carrier drug delivery system successfully, which showed perfect excellent T2 contrast magnetic resonance imaging, chemotherapy-sensitizing, tumor targeting , and anti-tumor effect, thus have the potential to be a new theranostic strategy for ovarian cancer patients.

Sign in / Sign up

Export Citation Format

Share Document