Multifunctional theranostic nanosystems enabling photothermal-chemo combination therapy of triple-stimuli-responsive drug release with magnetic resonance imaging

2020 ◽  
Vol 8 (7) ◽  
pp. 1875-1884 ◽  
Author(s):  
Xiao Lin ◽  
Xiaofang Song ◽  
Yiwei Zhang ◽  
Yanbing Cao ◽  
Yanan Xue ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Combination Therapy ◽  
Thermal Imaging ◽  
Stimuli Responsive ◽  
Resonance Imaging

As a multifunctional theranostic nanoplatform, FPCH-DOX NPs enable triple-stimuli responsive drug release for MR/thermal imaging-guided photothermal-chemo combination therapy.

Tuning the Thermoresponsive Properties of PEG-Based Fluorinated Polymers and Stimuli Responsive Drug Release for Switchable 19F Magnetic Resonance Imaging

2021 ◽  
Author(s):  
Adil Usman ◽  
Cheng Zhang ◽  
Jiacheng Zhao ◽  
Hui Peng ◽  
Nyoman Kurniawan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Free Radical ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Solution Temperature ◽  
Stimuli Responsive ◽  
Resonance Imaging ◽  
Critical Solution Temperature ◽  
19F Magnetic Resonance Imaging ◽  
Glycol Methyl Ether

A series of terpolymers of styrene, oligoethylene glycol methyl ether methacrylate and 2,2,2-trifluoroethyl acrylate were synthesized by free radical polymerization. The lower critical solution temperature (LCST) of the polymers was...

Composition–property relationships in multifunctional hollow mesoporous carbon nanosystems for PH-responsive magnetic resonance imaging and on-demand drug release

Nanoscale ◽  
2015 ◽  
Vol 7 (17) ◽  
pp. 7632-7643 ◽  
Author(s):  
Shengjian Zhang ◽  
Xiaoqing Qian ◽  
Linlin Zhang ◽  
Weijun Peng ◽  
Yu Chen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Mesoporous Carbon ◽  
Chemical Compositions ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Resonance Imaging ◽  
On Demand ◽  
Composition Property

A multiple stimuli-responsive theranostic system for cancer has been successfully developed simply by optimizing the chemical compositions of inorganic nanoplatforms.

scholarly journals Evaluation of Rectal and Skin Temperature Variations of Anesthetised Dogs Undergoing Magnetic Resonance Imaging Diagnosis

2019 ◽  
Vol 76 (2) ◽  
pp. 209
Author(s):  
Andra DEGAN ◽  
Ruxandra TUDOR ◽  
Ruxandra COSTEA ◽  
Dragoș BÎRȚOIU ◽  
Mihai SĂVESCU ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
General Anesthesia ◽  
Skin Temperature ◽  
Rectal Temperature ◽  
Thermal Imaging ◽  
Invasive Technique ◽  
Resonance Imaging ◽  
Temperature Variations ◽  
Before And After

General anesthesia produces different degrees of central nervous depression and changes in the peripheral circulation, therefore affecting the patient’s thermoregulatory mechanism. Moreover, the lack of proper, specially designed equipment for magnetic resonance imaging (MRI) environment monitoring can represent a challenge for the anesthetist. We examined the temperature variations correlated with different anesthetic protocols in dogs that underwent general anesthesia in order to evaluate changes in rectal and distal extremities temperature, before and after anesthesia. This study was conducted at the Faculty of Veterinary Medicine in Bucharest, on 21 dogs that were divided in 3 groups depending on the anesthetic protocol used. First group (B) received butorphanol (0.2 mg/kg, intravenously IV), second group (BK) had butorphanol (0.2 mg/kg) and a low dose of ketamine (2 mg/kg) IV, and group 3 (BM) was premedicated with butorphanol (0.2 mg/kg) and midazolam (0.2 mg/kg) IV. All patients were induced with propofol i.v. (3.24±0.68), intubated and maintained with isoflurane and oxygen. We determined rectal temperature before and right after the end of anesthesia with a digital thermometer and distal extremities temperature with the use of a thermal imaging camera attached to a smartphone. There was no significant difference between the rectal temperature before and after anesthesia within the 3 groups. Patients in group BK had a significant change in skin temperature at the end of anesthesia in all limbs (from 310C to 29.8 0C, p=0.008 and from 31 0C to 29.70C, p=0.009), respectively). Temperature variations were presented before and at the end of anesthesia, for all the groups especially at skin level. This study revealed that mobile thermal imaging represents a non-invasive technique that is helpful in assessing real time temperature changes in patients undergoing general anesthesia.

scholarly journals Eccentric magnetic microcapsules for MRI-guided local administration and pH-regulated drug release

RSC Advances ◽  
2018 ◽  
Vol 8 (73) ◽  
pp. 41956-41965
Author(s):  
Jingxian Huang ◽  
Wenwei Huang ◽  
Yin Chen ◽  
Yu Shrike Zhang ◽  
Jinshuang Zhong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Local Administration ◽  
Resonance Imaging ◽  
Mri Guided

Uniform eccentric magnetic microcapsules for magnetic resonance imaging-guided local administration and pH-regulated drug release were developed.

Targeted, Stimuli-Responsive, and Theranostic 19F Magnetic Resonance Imaging Probes

2019 ◽  
Vol 30 (10) ◽  
pp. 2502-2518 ◽  
Author(s):  
Mi Hyeon Cho ◽  
Soo Hyun Shin ◽  
Sang Hyun Park ◽  
Deepak Kana Kadayakkara ◽  
Daehong Kim ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Stimuli Responsive ◽  
Resonance Imaging ◽  
Imaging Probes ◽  
19F Magnetic Resonance Imaging

Stimuli-responsive biodegradable and gadolinium-based poly[N-(2-hydroxypropyl) methacrylamide] copolymers: their potential as targeting and safe magnetic resonance imaging probes

2017 ◽  
Vol 5 (15) ◽  
pp. 2763-2774 ◽  
Author(s):  
Xue Li ◽  
Ling Sun ◽  
Xiaoli Wei ◽  
Qiang Luo ◽  
Hao Cai ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Signal Intensity ◽  
Stimuli Responsive ◽  
Resonance Imaging ◽  
Hydroxypropyl Methacrylamide ◽  
Imaging Probes ◽  
Good Biocompatibility

Functionalized and biodegradable block pHPMA copolymer–gadolinium conjugates demonstrated good biocompatibility, high T1 relaxivity, and enhanced tumor signal intensity for MRI.

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