Temperature-Responsive Multilayer Films Based on Block Copolymer-Coated Silica Nanoparticles for Long-Term Release of Favipiravir

2021 ◽  
Author(s):  
Li Xu ◽  
Xingxing Zhang ◽  
Zihan Chu ◽  
Hailong Wang ◽  
Yinzhao Li ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Silica Nanoparticles ◽  
Multilayer Films ◽  
Temperature Responsive

Temperature-Responsive Multilayer Films of Micelle-Based Composites for Controlled Release of a Third-Generation EGFR Inhibitor

2020 ◽  
Vol 2 (2) ◽  
pp. 741-750 ◽  
Author(s):  
Li Xu ◽  
Hailong Wang ◽  
Zihan Chu ◽  
Lawrence Cai ◽  
Haifeng Shi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Multilayer Films ◽  
Third Generation ◽  
Egfr Inhibitor ◽  
Temperature Responsive

Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment

2019 ◽  
Vol 7 (10) ◽  
pp. 4195-4207 ◽  
Author(s):  
Thai Minh Duy Le ◽  
Bo-Kyeong Jung ◽  
Yi Li ◽  
Huu Thuy Trang Duong ◽  
Thanh Loc Nguyen ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Temperature Responsive ◽  
Oncolytic Adenoviruses ◽  
Term Delivery ◽  
Physically Crosslinked ◽  
Hydrogel System

A dual pH- and temperature-responsive physically crosslinked and injectable hydrogel system was developed for efficient and long-term delivery of oncolytic adenoviruses (Ads).

Fluorescent non-porous silica nanoparticles for long-term cell monitoring: Cytotoxicity and particle functionality

2013 ◽  
Vol 9 (11) ◽  
pp. 9183-9193 ◽  
Author(s):  
Stefaan J. Soenen ◽  
Bella Manshian ◽  
Shareen H. Doak ◽  
Stefaan C. De Smedt ◽  
Kevin Braeckmans
Keyword(s):  
Silica Nanoparticles ◽  
Porous Silica ◽  
Cell Monitoring

Emerging investigator series: Long-term exposure of amorphous silica nanoparticles disrupts the lysosomal and cholesterol homeostasis in macrophages

2021 ◽  
Author(s):  
Ronglin Ma ◽  
Xiaoming Cai ◽  
Ye Zhou ◽  
Xi Liu ◽  
Di Wu ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Cholesterol Homeostasis

Amorphous silica nanoparticles (ASiNPs) are generally considered to be biocompatible with limited acute toxicity. These nanoparticles were therefore exploited in diverse nanoproducts (e.g. foods and cosmetics) and may be released...

Fabrication and Deformation of Mechanochromic Nanocomposite Elastomers Based on Rubbery and Glassy Block Copolymer-Grafted Silica Nanoparticles

2020 ◽  
Vol 53 (11) ◽  
pp. 4541-4551
Author(s):  
Chao-Hung Cheng ◽  
Shiori Masuda ◽  
Shuhei Nozaki ◽  
Chigusa Nagano ◽  
Tomoyasu Hirai ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Silica Nanoparticles

scholarly journals Silica nanoparticles induce unfolded protein reaction mediated apoptosis in spermatocyte cells

2020 ◽  
Vol 9 (4) ◽  
pp. 454-460
Author(s):  
Lihua Ren ◽  
Jianhui Liu ◽  
Jialiu Wei ◽  
Yefan Du ◽  
Kaiyue Zou ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Low Dose ◽  
Caspase 3 ◽  
Reproductive Toxicity ◽  
Chronic Effect ◽  
Unfolded Protein ◽  
Induced Apoptosis ◽  
Protein Response ◽  
Protein Reaction

Abstract With increasing air pollution, silica nanoparticles (SiNPs), as a main inorganic member of PM2.5, have gained increasing attention to its reproductive toxicity. Most existing studies focused on the acute exposure, while data regarding the chronic effect of SiNPs on reproduction is limited. Therefore, this study was designed to evaluate the chronic toxicity of SiNPs on spermatocyte cells. The cells were continuously exposed to SiNPs for 1, 10, 20 and 30 generations at dose of 5 μg/ml SiNPs for 24 h per generation after attachment. The results showed that with the increasing generations of the exposure, SiNPs decreased the viability of spermatocyte cells, induced apoptosis and increased the level of reactive oxygen species in spermatocyte cells. Moreover, SiNPs increased the protein expression of GRP-78, p-PERK, IRE1α, ATF6 and Cleaved caspase-3 in spermatocyte cells, suggesting that SiNPs improved unfolded protein response (UPR) and apoptosis. The present results indicated that the long-term and low-dose exposure to SiNPs could induce apoptosis by triggering ROS-mediated UPR in spermatocyte cells.

scholarly journals Versatile Layer-By-Layer Highly Stable Multilayer Films: Study of the Loading and Release of FITC-Labeled Short Peptide in the Drug Delivery Field

Materials ◽  
2019 ◽  
Vol 12 (8) ◽  
pp. 1206 ◽  
Author(s):  
Kun Nie ◽  
Xiang Yu ◽  
Navnita Kumar ◽  
Yihe Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Multilayer Films ◽  
Layer By Layer ◽  
Guest Molecules ◽  
Potential Applications ◽  
Spatio Temporal ◽  
Release Speed

A viable short FITC-peptide immobilization is the most essential step in the fabrication of multilayer films based on FITC-peptide. These functional multilayer films have potential applications in drug delivery, medical therapy, and so forth. These FITC-peptides films needed to be handled with a lot of care and precision due to their sensitive nature. In this study, a general immobilization method is reported for the purpose of stabilizing various kinds of peptides at the interfacial regions. Utilizing Mesoporous silica nanoparticles can help in the preservation of these FITC-peptides by embedding themselves into these covalently cross-linked multilayers. This basic outlook of the multilayer films is potent enough and could be reused as a positive substrate. The spatio-temporal retention property of peptides can be modulated by varying the number of capping layers. The release speed of guest molecules such as tyrosine within FITC-peptide or/and adamantane (Ad)-in short peptides could also be fine-tuned by the specific arrangements of the multilayers of mesoporous silica nanoparticles (MSNs) and hyaluronic acid- cyclodextrin (HA-CD) multilayer films.

Temperature Responsive Poly(N-isopropylacrylamide-block-styrene) Block Copolymer Coatings with Tunable Hydrophilicity

2020 ◽  
Vol 21 ◽  
pp. 100800
Author(s):  
Sanjeevi Prasath Sridhar ◽  
Ajith Kumar Soman ◽  
Tripura Sundari Sankaran ◽  
Saravanan Chandran ◽  
Brijitta Joseph
Keyword(s):  
Block Copolymer ◽  
Temperature Responsive

Long-term fate of silica nanoparticles interacting with human dermal fibroblasts

Biomaterials ◽  
2012 ◽  
Vol 33 (17) ◽  
pp. 4431-4442 ◽  
Author(s):  
Sandrine Quignard ◽  
Gervaise Mosser ◽  
Michel Boissière ◽  
Thibaud Coradin
Keyword(s):  
Silica Nanoparticles ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts
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