Symbiotic Self-Assembly Strategy toward Lipid-Encased Cross-Linked Polymer Nanoparticles for Efficient Gene Silencing

2019 ◽  
Vol 11 (28) ◽  
pp. 24971-24983 ◽  
Author(s):  
Kingshuk Dutta ◽  
Davide Bochicchio ◽  
Alexander E. Ribbe ◽  
Dominique Alfandari ◽  
Jesse Mager ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Self Assembly ◽  
Polymer Nanoparticles ◽  
Assembly Strategy ◽  
Efficient Gene

scholarly journals Catalytic self-assembly of a DNA dendritic complex for efficient gene silencing

2016 ◽  
Vol 52 (7) ◽  
pp. 1413-1415 ◽  
Author(s):  
Yifan Lv ◽  
Ruizi Peng ◽  
Yu Zhou ◽  
Xiaobing Zhang ◽  
Weihong Tan
Keyword(s):  
Gene Silencing ◽  
Self Assembly ◽  
Efficient Gene ◽  
Self Assembled ◽  
Low Cytotoxicity

A catalytic self-assembled DNA dendritic complex was herein reported for efficient and convenient siRNA-based gene silencing with low cytotoxicity.

scholarly journals Gold-DNA nanosunflowers for efficient gene silencing with controllable transformation

2019 ◽  
Vol 5 (10) ◽  
pp. eaaw6264 ◽  
Author(s):  
Shuaidong Huo ◽  
Ningqiang Gong ◽  
Ying Jiang ◽  
Fei Chen ◽  
Hongbo Guo ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Self Assembly ◽  
Near Infrared ◽  
Irradiation Time ◽  
Nucleic Acid Delivery ◽  
Efficient Gene ◽  
Efficient Delivery ◽  
Triplex Forming Oligonucleotide

The development of an efficient delivery system for enhanced and controlled gene interference–based therapeutics is still facing great challenges. Fortunately, the flourishing field of nanotechnology provides more effective strategies for nucleic acid delivery. Here, the triplex-forming oligonucleotide sequence and its complementary strand were used to mediate self-assembly of ultrasmall gold nanoparticles. The obtained sunflower-like nanostructures exhibited strong near-infrared (NIR) absorption and photothermal conversion ability. Upon NIR irradiation, the large-sized nanostructure could disassemble and generate ultrasmall nanoparticles modified with c-myc oncogene silencing sequence, which could directly target the cell nucleus. Moreover, the controlled gene silencing effect could be realized by synergistically controlling the preincubation time with the self-assembled nanostructure (in vitro and in vivo) and NIR irradiation time point. This study provides a new approach for constructing more efficient and tailorable nanocarriers for gene interference applications.

scholarly journals siRNA Delivery: Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing (Small 27/2016)

Small ◽  
2016 ◽  
Vol 12 (27) ◽  
pp. 3604-3604 ◽  
Author(s):  
Chao Chen ◽  
Paola Posocco ◽  
Xiaoxuan Liu ◽  
Qiang Cheng ◽  
Erik Laurini ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Conceptual Design ◽  
Self Assembly ◽  
Sirna Delivery ◽  
Efficient Gene

scholarly journals Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing

Small ◽  
2016 ◽  
Vol 12 (27) ◽  
pp. 3667-3676 ◽  
Author(s):  
Chao Chen ◽  
Paola Posocco ◽  
Xiaoxuan Liu ◽  
Qiang Cheng ◽  
Erik Laurini ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Conceptual Design ◽  
Self Assembly ◽  
Sirna Delivery ◽  
Efficient Gene

scholarly journals A cassava common mosaic virus vector for virus-induced gene silencing in cassava

Plant Methods ◽  
2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Decai Tuo ◽  
Peng Zhou ◽  
Pu Yan ◽  
Hongguang Cui ◽  
Yang Liu ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Mosaic Virus ◽  
Gene Function ◽  
Viral Vector ◽  
Function Analysis ◽  
Systemic Infection ◽  
Cdna Clones ◽  
Virus Induced Gene Silencing ◽  
Efficient Gene ◽  
Gene Function Analysis

Abstract Background Cassava is an important crop for food security and industry in the least-developed and developing countries. The completion of the cassava genome sequence and identification of large numbers of candidate genes by next-generation sequencing provide extensive resources for cassava molecular breeding and increase the need for rapid and efficient gene function analysis systems in cassava. Several plant virus-induced gene silencing (VIGS) systems have been developed as reverse genetic tools for rapid gene function analysis in cassava. However, these VIGS vectors could cause severe viral symptoms or inefficient gene silencing. Results In this study, we constructed agroinfection-compatible infectious cDNA clones of cassava common mosaic virus isolate CM (CsCMV-CM, genus Potexvirus, family Alphaflexiviridae) that causes systemic infection with mild symptoms in cassava. CsCMV-CM was then modified to a viral vector carrying the Nimble cloning frame, which facilitates the rapid and high-throughput cloning of silencing fragments into the viral genome. The CsCMV-based vector successfully silenced phytoene desaturase (PDS) and magnesium chelatase subunit I (ChlI) in different cassava varieties and Nicotiana benthamiana. The silencing of the ChlI gene could persist for more than two months. Conclusions This CsCMV-based VIGS system provides a new tool for rapid and efficient gene function studies in cassava.

Tunable Microstructures of Ultralong Organic Phosphorescence Materials

2021 ◽  
Author(s):  
Kun Liu ◽  
Kaiwei Huang ◽  
Anqi Lv ◽  
Wenpeng Ye ◽  
Yijun Yang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Solution Concentration ◽  
Assembly Strategy ◽  
Considerable Promise ◽  
Organic Phosphor

Three kinds of microstructures of one organic phosphor were perpared based on a solution-concentration-controlled self-assembly strategy. These microstructures show different phosphorescence efficiency, which holds considerable promise for the miniaturized optical...

A colon-targeted podophyllotoxin nanoprodrug: synthesis, characterization, and supramolecular hydrogel formation for the drug combination

2021 ◽  
Vol 9 (14) ◽  
pp. 3200-3209
Author(s):  
Wei Ha ◽  
Xiao-Bo Zhao ◽  
Wei-Hua Zhao ◽  
Jiang-Jiang Tang ◽  
Yan-Ping Shi
Keyword(s):  
Self Assembly ◽  
Drug Combination ◽  
Therapeutic Agents ◽  
Supramolecular Hydrogel ◽  
Assembly Strategy ◽  
Hydrogel Formation

An ingeniously designed podophyllotoxin nanoprodrug was synthesized and offered an effective platform for co-delivery of multiple therapeutic agents for drug combination via the hierarchical self-assembly strategy.

Green synthesis of mesoporous MnNbOx oxide by a liquid induced self-assembly strategy for low-temperature removal of NOx

2019 ◽  
Vol 55 (100) ◽  
pp. 15073-15076 ◽  
Author(s):  
Huifang Cheng ◽  
Guodong Feng ◽  
Zhenzhen Yang ◽  
Tao Wang ◽  
Francis Okejiri ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Low Temperature ◽  
Green Synthesis ◽  
Self Assembly ◽  
Assembly Strategy ◽  
Highly Porous

A highly porous MnNbOx with excellent low-temperature NOx reduction was fabricated by a facile, sustainable ionic liquid induced self-assembly strategy.

An interfacial self-assembly strategy to fabricate graphitic hollow porous carbon spheres for supercapacitor electrodes

Carbon ◽  
2021 ◽  
Vol 182 ◽  
pp. 860
Author(s):  
Xiao-hua Zhang ◽  
Xin-yu Gan ◽  
Bao-sheng Liu ◽  
Xiao-yan Yan ◽  
Xin-xin Zhao
Keyword(s):  
Porous Carbon ◽  
Self Assembly ◽  
Carbon Spheres ◽  
Assembly Strategy ◽  
Porous Carbon Spheres
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