Sustained release of ibuprofen from polymeric micelles with a high loading capacity of ibuprofen in media simulating gastrointestinal tract fluids

2012 ◽  
Vol 72 (6) ◽  
pp. 359-364 ◽  
Author(s):  
Yong Zhang ◽  
Jiajia Chen ◽  
Genghui Zhang ◽  
Jiawei Lu ◽  
Husheng Yan ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Sustained Release ◽  
Polymeric Micelles ◽  
High Loading ◽  
Loading Capacity

pH-Triggered copolymer micelles as drug nanocarriers for intracellular delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (35) ◽  
pp. 29149-29158 ◽  
Author(s):  
Weiju Hao ◽  
Danyang Liu ◽  
Yazhuo Shang ◽  
Junqi Zhang ◽  
Shouhong Xu ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Intracellular Delivery ◽  
Ph Sensitive ◽  
High Loading ◽  
Loading Capacity ◽  
Triggered Release ◽  
Copolymer Micelles ◽  
Drug Nanocarriers

We prepared pH-sensitive polymeric micelles which were used as nano-carriers and exhibited a high loading capacity and pH-triggered release of DOX.

scholarly journals Effects of morphology and pore size of mesoporous silicas on the efficiency of an immobilized enzyme

RSC Advances ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 10010-10017
Author(s):  
Ping-Chung Kuo ◽  
Zhi-Xun Lin ◽  
Tzi-Yi Wu ◽  
Chun-Han Hsu ◽  
Hong-Ping Lin ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Mesoporous Silica ◽  
Pore Size ◽  
Immobilized Enzyme ◽  
Mesoporous Silicas ◽  
High Loading ◽  
Loading Capacity ◽  
Silica Films

Mesoporous silica films were used as supports with high loading capacity and enzyme activity.

scholarly journals β-Cyclodextrin-poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors

2021 ◽  
Author(s):  
Sauradip Chaudhuri ◽  
Martha J. Fowler ◽  
Cassandra Baker ◽  
Sylwia A. Stopka ◽  
Michael S. Regan ◽  
...  
Keyword(s):  
Sustained Release ◽  
Hdac Inhibitors ◽  
High Loading ◽  
Amino Ester

Real time monitoring of peptide delivery in vitro using high payload pH responsive nanogels

2020 ◽  
Vol 11 (2) ◽  
pp. 425-432 ◽  
Author(s):  
Shegufta Farazi ◽  
Fan Chen ◽  
Henry Foster ◽  
Raelene Boquiren ◽  
Shelli R. McAlpine ◽  
...  
Keyword(s):  
Real Time ◽  
Intracellular Delivery ◽  
Peptide Delivery ◽  
High Loading ◽  
Loading Capacity ◽  
Ph Responsive ◽  
Real Time Monitoring ◽  
High Payload

A pH responsive pMAA nanogel that demonstrates high loading capacity and rapid intracellular delivery of hydrophilic peptides.

Preparation of porous cellulose 3,5-dimethylphenylcarbamate hybrid organosilica particles for chromatographic applications

2015 ◽  
Vol 3 (4) ◽  
pp. 620-628 ◽  
Author(s):  
Xilun Weng ◽  
Zongbi Bao ◽  
Zhiguo Zhang ◽  
Baogen Su ◽  
Huabin Xing ◽  
...  
Keyword(s):  
Silica Particles ◽  
Chiral Selector ◽  
High Loading ◽  
Loading Capacity ◽  
Functionalized Silica

Organic–inorganic hybrids incorporating cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC)-functionalized silica particles can exhibit a high loading capacity with high loadings of the chiral selector.

Design and synthesis of periodic mesoporous organosilica materials with a multi-compartment structure

RSC Advances ◽  
2015 ◽  
Vol 5 (109) ◽  
pp. 89397-89406 ◽  
Author(s):  
Chun Xiang Cynthia Lin ◽  
Siddharth Jambhrunkar ◽  
Pei Yuan ◽  
Chun Hui Clayton Zhou ◽  
George Xiu Song Zhao
Keyword(s):  
Anticancer Drug ◽  
Release Rate ◽  
Slow Release ◽  
Drug Carrier ◽  
High Loading ◽  
Loading Capacity ◽  
Periodic Mesoporous Organosilica ◽  
Design And Synthesis ◽  
Mesoporous Organosilica ◽  
Organosilica Materials

Multi-compartment periodic mesoporous organosilica materials show desirable properties as anticancer drug carrier with high loading capacity and slow release rate.

Development of propolis-loaded block copolymer micelles of superior structural stability and high loading capacity

Polymer ◽  
2017 ◽  
Vol 125 ◽  
pp. 102-109 ◽  
Author(s):  
Petar D. Petrov ◽  
Georgy Grancharov ◽  
Valeria Gancheva ◽  
Boryana Trusheva ◽  
Vassya Bankova ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Structural Stability ◽  
High Loading ◽  
Loading Capacity ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

scholarly journals Synthesis of pH-Sensitive and Self-Fluorescent Polymeric Micelles Derived From Rosin and Vegetable Oils via ATRP

2021 ◽  
Vol 9 ◽  
Author(s):  
Juan Yu ◽  
Chaoqun Xu ◽  
Chuanwei Lu ◽  
Qian Liu ◽  
Jifu Wang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Vegetable Oils ◽  
Renewable Resources ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Dehydroabietic Acid ◽  
Great Promise ◽  
Loading Capacity ◽  
Carboxylic Groups ◽  
Ph Dependent

Preparation and application of sustainable polymers derived from renewable resources are of great significance. The aim of this study is to synthesize a kind of sustainable polymeric micelles from rosin and vegetable oils via atom transfer radical polymerization (ATRP) and to investigate the doxorubicin delivery properties of these micelles. Dehydroabietic acid–based poly lauryl methacrylate (DA-PLMA) with narrow PDI of 1.13 was prepared in a well-controlled process using rosin as an ATRP initiator. Thereafter, carboxylic groups were introduced to form poly methacrylic acid (PMAA) moieties in DA-PLMA polymer via acid hydrolysis. The resulted DA-PLMA-PMAA could self-assemble in water to form pH-dependent polymeric micelles with a diameter of ∼65 nm and PDI as low as 0.105. Owing to the existence of rosin, DA-PLMA-PMAA micelles also showed self-fluorescence properties. In addition, Dox-loaded micelles were prepared in aqueous solution with the drug-loading capacity as high as 16.0% and showed sustained-release characteristics. These results demonstrate great promise for designing polymeric micellar from rosin and vegetable oils.

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