Ultralong Hydroxyapatite Nanowire-Based Filter Paper for High-Performance Water Purification

2019 ◽  
Vol 11 (4) ◽  
pp. 4288-4301 ◽  
Author(s):  
Qiang-Qiang Zhang ◽  
Ying-Jie Zhu ◽  
Jin Wu ◽  
Yue-Ting Shao ◽  
An-Yong Cai ◽  
...  
2018 ◽  
Vol 2 (7) ◽  
pp. 1800031 ◽  
Author(s):  
Olof Gustafsson ◽  
Levon Manukyan ◽  
Albert Mihranyan

Biomedicines ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. 209 ◽  
Author(s):  
Lulu Wu ◽  
Athanasios Mantas ◽  
Simon Gustafsson ◽  
Levon Manukyan ◽  
Albert Mihranyan

This study is dedicated to the rapid removal of protein aggregates and viruses from plasma-derived human serum albumin (HSA) product to reduce the risk of viral contamination and increase biosafety. A two-step filtration approach was implemented to first remove HSA aggregates and then achieve high model virus clearance using a nanocellulose-based filter paper of different thicknesses, i.e., 11 μm (prefilter) and 22 μm (virus filter) at pH 7.4 and room temperature. The pore size distribution of these filters was characterized by nitrogen gas sorption analysis. Dynamic light scattering (DLS) and size-exclusion high performance liquid chromatography (SE-HPLC) were performed to analyze the presence of HSA aggregates in process intermediates. The virus filter showed high clearance of a small-size model virus, i.e., log10 reduction value (LRV) > 5, when operated at 3 and 5 bar, but a distinct decrease in LRV was detected at 1 bar, i.e., LRV 2.65–3.75. The throughput of HSA was also dependent on applied transmembrane pressure as was seen by Vmax values of 110 ± 2.5 L m−2 and 63.6 ± 5.8 L m−2 at 3 bar and 5 bar, respectively. Protein loss was low, i.e., recovery > 90%. A distribution of pore sizes between 40 nm and 60 nm, which was present in the prefilter and absent in the virus filter, played a crucial part in removing the HSA aggregates and minimizing the risk of virus filter fouling. The presented results enable the application of virus removal nanofiltration of HSA in bioprocessing as an alternative to virus inactivation methods based, e.g., on heat treatment.


Author(s):  
Jian Xiong ◽  
Ailin Li ◽  
Ye Liu ◽  
Liming Wang ◽  
Xiaohong Qin ◽  
...  

Integrating metal-organic frameworks (MOFs) into flexible polymeric matrices can improve their practical processibility and enlarge industrial applications greatly. However, current methods suffer from the serious aggregation of MOFs, low MOF...


Membranes ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 137
Author(s):  
Hongyi Han ◽  
Ruobin Dai ◽  
Zhiwei Wang

Widespread applications of nanofiltration (NF) and reverse osmosis (RO)-based processes for water purification and desalination call for high-performance thin-film composite (TFC) membranes. In this work, a novel and facile modification method was proposed to fabricate high-performance thin-film composite nanofiltration membrane by introducing Ca2+ in the heat post-treatment. The introduction of Ca2+ induced in situ Ca2+-carboxyl intra-bridging, leading to the embedment of Ca2+ in the polyamide (PA) layer. This post modification enhanced the hydrophilicity and surface charge of NF membranes compared to the pristine membrane. More interestingly, the modified membrane had more nodules and exhibited rougher morphology. Such changes brought by the addition of Ca2+ enabled the significant increase of water permeability (increasing from 17.9 L·m−2·h−1·bar−1 to 29.8 L·m−2·h−1·bar−1) while maintaining a high selectivity (Na2SO4 rejection rate of 98.0%). Furthermore, the intra-bridging between calcium and carboxyl imparted the NF membranes with evident antifouling properties, exhibiting milder permeability decline of 4.2% (compared to 16.7% of NF-control) during filtration of sodium alginate solution. The results highlight the potential of using Ca2+-carboxyl intra-bridging post-treatment to fabricate high-performance TFC membranes for water purification and desalination.


Cellulose ◽  
2018 ◽  
Vol 26 (2) ◽  
pp. 1183-1194 ◽  
Author(s):  
Zhiguo Wang ◽  
Wenwen Zhang ◽  
Juan Yu ◽  
Lijun Zhang ◽  
Liang Liu ◽  
...  

1994 ◽  
Vol 20 (3) ◽  
pp. 360-366
Author(s):  
Yasuo Koseki ◽  
Nobuko Hashimoto ◽  
Kazuhiko Takino ◽  
Toshihiko Kaneko ◽  
Syunji Honma

2019 ◽  
Vol 1 (1) ◽  
pp. 342-346 ◽  
Author(s):  
Yili Zhao ◽  
Lei Liu ◽  
Daniel Shi ◽  
Xiangyang Shi ◽  
Mingwu Shen

Palladium nanoparticles can be facilely immobilized onto filter paper via mediation by polyethylenimine for high-performance catalytic applications.


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