scholarly journals Mille-Feuille Filter Paper: High-Performance Virus Removal Filter Paper for Drinking Water Purification (Global Challenges 7/2018)

2018 ◽  
Vol 2 (7) ◽  
pp. 1870174
Author(s):  
Olof Gustafsson ◽  
Levon Manukyan ◽  
Albert Mihranyan
Keyword(s):  
Drinking Water ◽  
Water Purification ◽  
Filter Paper ◽  
High Performance ◽  
Virus Removal ◽  
Global Challenges ◽  
Drinking Water Purification

scholarly journals High-Performance Virus Removal Filter Paper for Drinking Water Purification

2018 ◽  
Vol 2 (7) ◽  
pp. 1800031 ◽  
Author(s):  
Olof Gustafsson ◽  
Levon Manukyan ◽  
Albert Mihranyan
Keyword(s):  
Drinking Water ◽  
Water Purification ◽  
Filter Paper ◽  
High Performance ◽  
Virus Removal ◽  
Drinking Water Purification

A reduced graphene oxide nanofiltration membrane intercalated by well-dispersed carbon nanotubes for drinking water purification

Nanoscale ◽  
2016 ◽  
Vol 8 (10) ◽  
pp. 5696-5705 ◽  
Author(s):  
Xianfu Chen ◽  
Minghui Qiu ◽  
Hao Ding ◽  
Kaiyun Fu ◽  
Yiqun Fan
Keyword(s):  
Carbon Nanotubes ◽  
Drinking Water ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Water Purification ◽  
High Performance ◽  
Nanofiltration Membrane ◽  
Reduced Graphene ◽  
Drinking Water Purification

A high-performance graphene-based nanofiltration membrane intercalated by well-dispersed carbon nanotubes for drinking water purification.

scholarly journals Scalable and Sustainable Total Pathogen Removal Filter Paper for Point-of-Use Drinking Water Purification in Bangladesh

2019 ◽  
Vol 7 (17) ◽  
pp. 14373-14383 ◽  
Author(s):  
Olof Gustafsson ◽  
Levon Manukyan ◽  
Simon Gustafsson ◽  
Gopi Krishna Tummala ◽  
Sharmin Zaman ◽  
...  
Keyword(s):  
Drinking Water ◽  
Water Purification ◽  
Filter Paper ◽  
Pathogen Removal ◽  
Point Of Use ◽  
Drinking Water Purification

scholarly journals Aggregate Removal Nanofiltration of Human Serum Albumin Solution Using Nanocellulose-Based Filter Paper

Biomedicines ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. 209 ◽  
Author(s):  
Lulu Wu ◽  
Athanasios Mantas ◽  
Simon Gustafsson ◽  
Levon Manukyan ◽  
Albert Mihranyan
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Filter Paper ◽  
High Performance ◽  
Size Exclusion ◽  
Transmembrane Pressure ◽  
Protein Loss ◽  
Virus Removal ◽  
Model Virus

This study is dedicated to the rapid removal of protein aggregates and viruses from plasma-derived human serum albumin (HSA) product to reduce the risk of viral contamination and increase biosafety. A two-step filtration approach was implemented to first remove HSA aggregates and then achieve high model virus clearance using a nanocellulose-based filter paper of different thicknesses, i.e., 11 μm (prefilter) and 22 μm (virus filter) at pH 7.4 and room temperature. The pore size distribution of these filters was characterized by nitrogen gas sorption analysis. Dynamic light scattering (DLS) and size-exclusion high performance liquid chromatography (SE-HPLC) were performed to analyze the presence of HSA aggregates in process intermediates. The virus filter showed high clearance of a small-size model virus, i.e., log10 reduction value (LRV) > 5, when operated at 3 and 5 bar, but a distinct decrease in LRV was detected at 1 bar, i.e., LRV 2.65–3.75. The throughput of HSA was also dependent on applied transmembrane pressure as was seen by Vmax values of 110 ± 2.5 L m−2 and 63.6 ± 5.8 L m−2 at 3 bar and 5 bar, respectively. Protein loss was low, i.e., recovery > 90%. A distribution of pore sizes between 40 nm and 60 nm, which was present in the prefilter and absent in the virus filter, played a crucial part in removing the HSA aggregates and minimizing the risk of virus filter fouling. The presented results enable the application of virus removal nanofiltration of HSA in bioprocessing as an alternative to virus inactivation methods based, e.g., on heat treatment.

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