Selective De-Cross-Linking of Transformable, Double-Network Hydrogels: Preparation, Structural Conversion, and Controlled Release

2018 ◽  
Vol 10 (49) ◽  
pp. 42985-42991 ◽  
Author(s):  
Doyoung Jung ◽  
Kyoung Min Lee ◽  
Ji Young Chang ◽  
Misun Yun ◽  
Hak-Jong Choi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cross Linking ◽  
Structural Conversion ◽  
Double Network

Multilayer composite beads constructed via layer-by-layer self-assembly for lysozyme controlled release

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24369-24376 ◽  
Author(s):  
Jiemin Zhao ◽  
Xiaoping Wang ◽  
Yanshen Kuang ◽  
Yufeng Zhang ◽  
Xiaowen Shi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Self Assembly ◽  
Cross Linking ◽  
Layer By Layer ◽  
Multilayer Composite ◽  
Composite Beads ◽  
Assembly Technique ◽  
Positively Charged

Alginate (ALG)–lysozyme (LZ) beads were fabricated by a cross-linking process. Negatively charged ALG and positively charged LZ were alternately deposited on the positively charged ALG–LZ beads via a layer-by-layer (LBL) self-assembly technique.

Citric Acid Cross-Linking of Carboxymethyl Sago Starch Based Hydrogel for Controlled Release Application

2018 ◽  
Vol 382 (1) ◽  
pp. 1800086 ◽  
Author(s):  
Nurul Aida Nordin ◽  
Norizah Abdul Rahman ◽  
Norhashidah Talip ◽  
Norzita Yacob
Keyword(s):  
Citric Acid ◽  
Controlled Release ◽  
Cross Linking ◽  
Sago Starch

Double-Network Physical Cross-Linking Strategy To Promote Bulk Mechanical and Surface Adhesive Properties of Hydrogels

2019 ◽  
Vol 52 (24) ◽  
pp. 9512-9525 ◽  
Author(s):  
Li Tang ◽  
Dong Zhang ◽  
Liang Gong ◽  
Yanxian Zhang ◽  
Shaowen Xie ◽  
...  
Keyword(s):  
Cross Linking ◽  
Adhesive Properties ◽  
Double Network

scholarly journals CONTROLLED DELIVERY OF ANTIRETROVIRAL DRUG-LOADED CROSS-LINKED MICROSPHERES BY IONIC GELATION METHOD

2016 ◽  
Vol 9 (5) ◽  
pp. 264
Author(s):  
S. Princely ◽  
Saleem Basha N ◽  
Saleem Basha N ◽  
Nandhakumar S ◽  
Dhanaraju Md
Keyword(s):  
Differential Scanning Calorimetry ◽  
Particle Size ◽  
Fourier Transform ◽  
Controlled Release ◽  
Cross Linking ◽  
Ionic Gelation ◽  
Scanning Calorimetry ◽  
Gelatin Microspheres ◽  
Antiretroviral Drug

ABSTRACTObjective: Lamivudine (LVD) is a nucleoside reverse transcriptase inhibitor originally developed as an antiretroviral drug and primarily used in thetreatment of most common chronic disease of the planet, acquired immune deficiency syndrome and hepatitis B. The main objective of the study is todevelop controlled drug delivery system to increase the efficacy of antiretroviral drug, LVD against human immunodeficiency virus infections.Methods: The microencapsulation of LVD in gelatin microspheres was carried out by cross-linking process with glutaraldehyde saturated tolueneusing ionic-gelation method. The prepared microspheres were evaluated for particle size analysis, % yield value, % drug content, drug entrapmentefficiency, scanning electron microscopy for surface morphology, swelling index, accelerated stability studies, Fourier transform infrared radiationspectroscopy (FT-IR) and differential scanning calorimetry (DSC) for polymer drug compatibility, in vitro dissolution efficiency and release kineticstudies.Results: The obtained microspheres showed very smooth surface and exhibited regular spherical geometry due to higher crosslinking density. FT-IRand DSC revealed the absence of drug polymer interactions. The percentage yield, entrapment efficiency and drug content for F6 LVD microsphereswas found to be 79.31%, 65.55% and 96.25% respectively. The particle size was ranged from 34.61% to 51.45 µm sizes and in vitro release profileshowed that cross-linking density of gelatin microspheres effectively controlled the release of LVD.Conclusion: The findings of our investigation demonstrated that F6 of gelatin-LVD microspheres had good controlled release profile with maximumentrapment efficiency and prolonged drug release for 24 hrs or longer and this formulation would be capable of overcoming the drawbacks andlimitations of LVD conventional dosage forms.Keywords: Lamivudine, Microspheres, Controlled release, Gelatin, Fourier transform infrared, Differential scanning calorimetry, In vitro releasekinetics.

Preparation of single or double-network chitosan/poly(vinyl alcohol) gel films through selectively cross-linking method

2009 ◽  
Vol 77 (4) ◽  
pp. 718-724 ◽  
Author(s):  
Songmiao Liang ◽  
Linshu Liu ◽  
Qingrong Huang ◽  
Kit L. Yam
Keyword(s):  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Cross Linking ◽  
Double Network

A Model for the Mullins Effect in Multinetwork Elastomers

2017 ◽  
Vol 84 (12) ◽  
Author(s):  
Mattia Bacca ◽  
Costantino Creton ◽  
Robert M. McMeeking
Keyword(s):  
Damage Model ◽  
Hydrostatic Compression ◽  
Cross Linking ◽  
Mullins Effect ◽  
Maximum Strain ◽  
Double Network ◽  
Proposed Model ◽  
Damage Process ◽  
Composite Stiffness ◽  
Highly Loaded

Double and triple network (TN) elastomers can be made by infusing monomers into a single network (SN) polymer, causing it to swell, and then polymerizing and cross-linking the monomers. The result is a double network (DN) elastomer in which one network is stretched and the other is in hydrostatic compression. TN systems are made by repeating the process starting with the DN material. The multinetwork (MN) elastomers exhibit a Mullins effect in which softening occurs upon a first cycle of loading, with the elastomer stiffness recovered above the previous maximum strain. The Mullins effect is attributed to rupture of the stretched network, eliminating the constraint on the compressed network, thereby motivating straining at the lower stiffness of the remaining material. A model for this process is developed, based on the previous work of Horgan et al. (2004, “A Theory of Stress Softening of Elastomers Based on Finite Chain Extensibility,” Proc. R. Soc. A, 460(2046), pp. 1737–1754). In the proposed model, a composite stiffness for the MN system is developed and a damage process introduced to degrade the contribution of the stretched network. The damage model is designed to account for the progressive elimination of chains that are most highly loaded in the stretched network, so that the undamaged stiffness is restored when the strain rises above levels previously experienced. The proposed model reproduces the behavior of the Mullins effect in the MN system.

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