Droplet-Based Microfluidic Synthesis of Hydrogel Microparticles via Click Chemistry-Based Cross-Linking for the Controlled Release of Proteins

2021 ◽  
Author(s):  
Casper H.Y. Chung ◽  
Chi Ming Laurence Lau ◽  
Dixon T. Sin ◽  
Jin Teng Chung ◽  
Yuzi Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Click Chemistry ◽  
Cross Linking ◽  
Hydrogel Microparticles

Multilayer composite beads constructed via layer-by-layer self-assembly for lysozyme controlled release

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24369-24376 ◽  
Author(s):  
Jiemin Zhao ◽  
Xiaoping Wang ◽  
Yanshen Kuang ◽  
Yufeng Zhang ◽  
Xiaowen Shi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Self Assembly ◽  
Cross Linking ◽  
Layer By Layer ◽  
Multilayer Composite ◽  
Composite Beads ◽  
Assembly Technique ◽  
Positively Charged

Alginate (ALG)–lysozyme (LZ) beads were fabricated by a cross-linking process. Negatively charged ALG and positively charged LZ were alternately deposited on the positively charged ALG–LZ beads via a layer-by-layer (LBL) self-assembly technique.

An injectable and self-healing hydrogel with covalent cross-linking in vivo for cranial bone repair

2017 ◽  
Vol 5 (20) ◽  
pp. 3739-3748 ◽  
Author(s):  
Shaoyu Lü ◽  
Xiao Bai ◽  
Haidi Liu ◽  
Piao Ning ◽  
Zengqiang Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Bone Repair ◽  
Cranial Bone ◽  
Cross Linking ◽  
Self Healing

DA click chemistry and dynamic acylhydrazone bond cross-linking are employed to obtain injectable and self-healing hydrogels for cranial bone repair.

Selective De-Cross-Linking of Transformable, Double-Network Hydrogels: Preparation, Structural Conversion, and Controlled Release

2018 ◽  
Vol 10 (49) ◽  
pp. 42985-42991 ◽  
Author(s):  
Doyoung Jung ◽  
Kyoung Min Lee ◽  
Ji Young Chang ◽  
Misun Yun ◽  
Hak-Jong Choi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cross Linking ◽  
Structural Conversion ◽  
Double Network

Citric Acid Cross-Linking of Carboxymethyl Sago Starch Based Hydrogel for Controlled Release Application

2018 ◽  
Vol 382 (1) ◽  
pp. 1800086 ◽  
Author(s):  
Nurul Aida Nordin ◽  
Norizah Abdul Rahman ◽  
Norhashidah Talip ◽  
Norzita Yacob
Keyword(s):  
Citric Acid ◽  
Controlled Release ◽  
Cross Linking ◽  
Sago Starch

Biopolymers from Vegetable Oils via Catalyst- and Solvent-Free “Click” Chemistry: Effects of Cross-Linking Density

2011 ◽  
Vol 13 (1) ◽  
pp. 261-266 ◽  
Author(s):  
Jian Hong ◽  
Qiang Luo ◽  
Xianmei Wan ◽  
Zoran S. Petrović ◽  
Bipin K. Shah
Keyword(s):  
Click Chemistry ◽  
Vegetable Oils ◽  
Solvent Free ◽  
Cross Linking

Diels–Alder “click” chemistry for the cross-linking of furfuryl-gelatin-polyetheramine hydrogels

RSC Advances ◽  
2014 ◽  
Vol 4 (67) ◽  
pp. 35578 ◽  
Author(s):  
C. García-Astrain ◽  
A. Gandini ◽  
C. Peña ◽  
I. Algar ◽  
A. Eceiza ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Diels Alder ◽  
Cross Linking ◽  
The Cross

Intramolecular Cross-linking of Polymers Using Difunctional Acetylenes via Click Chemistry

2011 ◽  
Vol 14 (1) ◽  
pp. 69-78 ◽  
Author(s):  
Halime Cengiz ◽  
Binnur Aydogan ◽  
Sahin Ates ◽  
Engin Acikalin ◽  
Yusuf Yagci
Keyword(s):  
Click Chemistry ◽  
Cross Linking

scholarly journals CONTROLLED DELIVERY OF ANTIRETROVIRAL DRUG-LOADED CROSS-LINKED MICROSPHERES BY IONIC GELATION METHOD

2016 ◽  
Vol 9 (5) ◽  
pp. 264
Author(s):  
S. Princely ◽  
Saleem Basha N ◽  
Saleem Basha N ◽  
Nandhakumar S ◽  
Dhanaraju Md
Keyword(s):  
Differential Scanning Calorimetry ◽  
Particle Size ◽  
Fourier Transform ◽  
Controlled Release ◽  
Cross Linking ◽  
Ionic Gelation ◽  
Scanning Calorimetry ◽  
Gelatin Microspheres ◽  
Antiretroviral Drug

ABSTRACTObjective: Lamivudine (LVD) is a nucleoside reverse transcriptase inhibitor originally developed as an antiretroviral drug and primarily used in thetreatment of most common chronic disease of the planet, acquired immune deficiency syndrome and hepatitis B. The main objective of the study is todevelop controlled drug delivery system to increase the efficacy of antiretroviral drug, LVD against human immunodeficiency virus infections.Methods: The microencapsulation of LVD in gelatin microspheres was carried out by cross-linking process with glutaraldehyde saturated tolueneusing ionic-gelation method. The prepared microspheres were evaluated for particle size analysis, % yield value, % drug content, drug entrapmentefficiency, scanning electron microscopy for surface morphology, swelling index, accelerated stability studies, Fourier transform infrared radiationspectroscopy (FT-IR) and differential scanning calorimetry (DSC) for polymer drug compatibility, in vitro dissolution efficiency and release kineticstudies.Results: The obtained microspheres showed very smooth surface and exhibited regular spherical geometry due to higher crosslinking density. FT-IRand DSC revealed the absence of drug polymer interactions. The percentage yield, entrapment efficiency and drug content for F6 LVD microsphereswas found to be 79.31%, 65.55% and 96.25% respectively. The particle size was ranged from 34.61% to 51.45 µm sizes and in vitro release profileshowed that cross-linking density of gelatin microspheres effectively controlled the release of LVD.Conclusion: The findings of our investigation demonstrated that F6 of gelatin-LVD microspheres had good controlled release profile with maximumentrapment efficiency and prolonged drug release for 24 hrs or longer and this formulation would be capable of overcoming the drawbacks andlimitations of LVD conventional dosage forms.Keywords: Lamivudine, Microspheres, Controlled release, Gelatin, Fourier transform infrared, Differential scanning calorimetry, In vitro releasekinetics.

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