Investigations of Peptide-Based Biocompatible Injectable Shape-Memory Hydrogels: Differential Biological Effects on Bacterial and Human Blood Cells

2018 ◽  
Vol 10 (13) ◽  
pp. 10729-10740 ◽  
Author(s):  
Pramod K. Gavel ◽  
Dharm Dev ◽  
Hamendra S. Parmar ◽  
Sheetal Bhasin ◽  
Apurba K. Das
Keyword(s):  
Shape Memory ◽  
Human Blood ◽  
Blood Cells ◽  
Biological Effects ◽  
Human Blood Cells

Biological effects of bacterial pigment undecylprodigiosin on human blood cells treated with atmospheric gas plasma in vitro

2017 ◽  
Vol 69 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Saša Lazović ◽  
Andreja Leskovac ◽  
Sandra Petrović ◽  
Lidija Senerovic ◽  
Nevena Krivokapić ◽  
...  
Keyword(s):  
Human Blood ◽  
Blood Cells ◽  
Biological Effects ◽  
Gas Plasma ◽  
Human Blood Cells ◽  
Bacterial Pigment

scholarly journals Biological Effects of Echinacea Purpurea on Human Blood Cells

2009 ◽  
Vol 60 (2) ◽  
pp. 165-172 ◽  
Author(s):  
Gordana Joksić ◽  
Sandra Petrović ◽  
Ivana Joksić ◽  
Andreja Leskovac
Keyword(s):  
Human Blood ◽  
Blood Cells ◽  
Biological Effects ◽  
Echinacea Purpurea ◽  
Adverse Health Effects ◽  
Dicentric Chromosomes ◽  
Human Blood Cells ◽  
Before And After ◽  
Radiation Workers

Biological Effects of Echinacea Purpurea on Human Blood CellsThe aim of this study was to investigate radioprotective properties of Echinacea purpurea tablets in vivo. We analysed lymphocyte chromosome aberrations (CA), micronuclei (MN), apoptosis of leukocytes and haematological parameters in a group of radiation workers who were identified as carrying dicentric chromosomes in their lymphocytes. All radiation workers were taking two 275 mg Echinacea tablets b.i.d., according to a pharmacist's recommendation. All parameters were analysed before and after the two-week treatment. At the end of the treatment lymphocyte CA frequency dropped significantly, and the number of apoptotic cells increased. The inverse lymphocyte-to-granulocyte ratio at the beginning of the study changed to normal at its end. In conclusion, biological effects observed after administration of Echinacea purpurea preparation suggest that it may be beneficial for the prevention of adverse health effects in workers exposed to ionising radiation.

scholarly journals Biological Effects of Cardiac Magnetic Resonance on Human Blood Cells

2015 ◽  
Vol 8 (9) ◽  
Author(s):  
Patrizio Lancellotti ◽  
Alain Nchimi ◽  
Céline Delierneux ◽  
Alexandre Hego ◽  
Christian Gosset ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Human Blood ◽  
Blood Cells ◽  
Biological Effects ◽  
Human Blood Cells

scholarly journals Cytotoxicity and genotoxicity of iron oxide nanoparticles: An in vitro biosafety study

2016 ◽  
Vol 68 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Erdal Sonmez ◽  
Elanur Aydin ◽  
Hasan Turkez ◽  
Elvan Özbek ◽  
Basak Togar ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Oxidative Damage ◽  
Cell Viability ◽  
Iron Oxide Nanoparticles ◽  
Human Blood ◽  
Blood Cells ◽  
Biological Effects ◽  
Oxide Nanoparticles ◽  
Human Blood Cells ◽  
Dose Dependent

With the development of nanotechnology and the wide use of iron oxide nanoparticles, it has become necessary to assess the potential adverse biological effects of magnetite. This study investigated the cytotoxicity, genotoxicity and oxidative damage of different concentrations of magnetite (0 to 1000 mg/L) in human whole blood cultures. After supplementation of magnetite, the blood samples were incubated for 72 h. Cell viability was assessed by the 3-(4,5-dimethyl-thiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) release assays. The total antioxidant capacity (TAC) and total oxidant status (TOS) were determined to evaluate the dose-dependent effects of magnetite on the oxidant/antioxidant balance and to evaluate the potential oxidative injury due to increased oxidative stress. Genotoxicity was estimated by by the sister chromatid exchange (SCE), micronuclei (MN) and chromosome aberration (CA) assays and determination of 8-oxo-2-deoxyguanosine (8-OH-dG) levels. The results of MTT and LDH assays showed that the higher concentrations of magnetite (100, 150, 300, 500 and 1000 mg/L) decreased cell viability. Concentrations of magnetite higher than 10 mg/L increased TOS levels and decreased TAC levels in human blood cells. Increasing concentrations of magnetite caused significant increases in MN, SCE and CA rates and 8-OH-dG levels. The obtained results showed that magnetite exerted dose-dependent effects on oxidative damage, genotoxicity and cytotoxicity in human blood cells.

Resonance impedance sensing of human blood cells

2008 ◽  
Vol 145-146 ◽  
pp. 29-36 ◽  
Author(s):  
Siyang Zheng ◽  
Mandheerej S. Nandra ◽  
Chi-Yuan Shih ◽  
Wei Li ◽  
Yu-Chong Tai
Keyword(s):  
Human Blood ◽  
Blood Cells ◽  
Impedance Sensing ◽  
Human Blood Cells

scholarly journals Differential DNA Methylation in Purified Human Blood Cells: Implications for Cell Lineage and Studies on Disease Susceptibility

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41361 ◽  
Author(s):  
Lovisa E. Reinius ◽  
Nathalie Acevedo ◽  
Maaike Joerink ◽  
Göran Pershagen ◽  
Sven-Erik Dahlén ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Human Blood ◽  
Blood Cells ◽  
Disease Susceptibility ◽  
Cell Lineage ◽  
Human Blood Cells
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