Biodegradable Drug-Loaded Hydroxyapatite Nanotherapeutic Agent for Targeted Drug Release in Tumors

2018 ◽  
Vol 10 (9) ◽  
pp. 7832-7840 ◽  
Author(s):  
Wen Sun ◽  
Jiangli Fan ◽  
Suzhen Wang ◽  
Yao Kang ◽  
Jianjun Du ◽  
...  
Keyword(s):  
Drug Release ◽  
Targeted Drug

scholarly journals Development of Novel Zn2+ Loaded Nanoparticles Designed for Cell-Type Targeted Drug Release in CNS Neurons: In Vitro Evidences

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e17851 ◽  
Author(s):  
Andreas M. Grabrucker ◽  
Craig C. Garner ◽  
Tobias M. Boeckers ◽  
Lucia Bondioli ◽  
Barbara Ruozi ◽  
...  
Keyword(s):  
Drug Release ◽  
Cell Type ◽  
Cns Neurons ◽  
Targeted Drug

Programmable shape-morphing microrobots for localized cancer cells treatment

2021 ◽  
Author(s):  
Chen Xin ◽  
Dongdong Jin ◽  
Yanlei Hu ◽  
Liang Yang ◽  
Rui Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Biological Applications ◽  
Proof Of Concept ◽  
Ph Responsive ◽  
Solution Ph ◽  
Shape Morphing ◽  
On Demand ◽  
Targeted Drug

Abstract Microrobots have attracted great attentions due to their wide applications in microobjects manipulation and targeted drug delivery. To realize more complex micro/nano cargos manipulation (e.g., encapsulation and release) in biological applications, endowing microrobots with shapes adaptability with the environment is highly desirable. Here, designable shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rate in a pH-responsive hydrogel. Combined with magnetic propelling, the shape-morphing microcrab (SMMC) is capable of performing targeted microparticle delivery, including gripping, transporting, and releasing through claws morphing. As a proof-of-concept demonstration, the shape-morphing microfish (SMMF) is designed to encapsulate drug (doxorubicin (DOX)) by closing mouth in phosphate buffer saline (PBS, pH~7.4) and release them by opening mouth in slightly acid solution (pH<7), which realize localized Hela cells treatment in an artificial vascular network. These SMMRs with powerful shape morphing capabilities and remote motion controllability provide new platforms for complex microcargos operation and on-demand drug release.

Light-responsive polymersomes with a charge-switch for targeted drug delivery

2020 ◽  
Vol 8 (4) ◽  
pp. 727-735 ◽  
Author(s):  
Yaowu Zhou ◽  
Rongrong Chen ◽  
Huiting Yang ◽  
Chunyan Bao ◽  
Jinyan Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Amphiphilic Polymer ◽  
Targeted Drug ◽  
A Charge

A cationic and lipid-like amphiphilic polymer was designed to form polymersomes for photo-responsive and targeted drug release.

Development of a mucoadhesive nanoparticulate drug delivery system for a targeted drug release in the bladder

2011 ◽  
Vol 416 (1) ◽  
pp. 339-345 ◽  
Author(s):  
Jan Barthelmes ◽  
Glen Perera ◽  
Juliane Hombach ◽  
Sarah Dünnhaupt ◽  
Andreas Bernkop-Schnürch
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug

Colon targeted drug release studies of 5-ASA using a novel pH sensitive polyacrylic acid grafted barley

2017 ◽  
Vol 74 (8) ◽  
pp. 3431-3453 ◽  
Author(s):  
Kartick Prasad Dey ◽  
Sumit Mishra ◽  
Nilendu Chandra
Keyword(s):  
Drug Release ◽  
Polyacrylic Acid ◽  
Ph Sensitive ◽  
Release Studies ◽  
Targeted Drug

scholarly journals Focused Ultrasound Hyperthermia for Targeted Drug Release from Thermosensitive Liposomes: Results from a Phase I Trial

Radiology ◽  
2019 ◽  
Vol 291 (1) ◽  
pp. 232-238 ◽  
Author(s):  
Michael D. Gray ◽  
Paul C. Lyon ◽  
Christophoros Mannaris ◽  
Lisa K. Folkes ◽  
Michael Stratford ◽  
...  
Keyword(s):  
Drug Release ◽  
Phase I ◽  
Phase I Trial ◽  
Focused Ultrasound ◽  
Thermosensitive Liposomes ◽  
Targeted Drug ◽  
Ultrasound Hyperthermia

scholarly journals A photochemical approach for controlled drug release in targeted drug delivery

2012 ◽  
Vol 20 (3) ◽  
pp. 1281-1290 ◽  
Author(s):  
Seok Ki Choi ◽  
Manisha Verma ◽  
Justin Silpe ◽  
Ryan E. Moody ◽  
Kenny Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Controlled Drug Release ◽  
Targeted Drug

Layer-by-layer assembled magnetic prednisolone microcapsules (MPC) for controlled and targeted drug release at rheumatoid arthritic joints

2017 ◽  
Vol 427 ◽  
pp. 258-267 ◽  
Author(s):  
Chakkarapani Prabu ◽  
Subbiah Latha ◽  
Palanisamy Selvamani ◽  
Fredrik Ahrentorp ◽  
Christer Johansson ◽  
...  
Keyword(s):  
Drug Release ◽  
Layer By Layer ◽  
Rheumatoid Arthritic ◽  
Targeted Drug ◽  
Arthritic Joints

Application of Smart Nanomaterials in Rheumatism Drug Delivery Systems

2014 ◽  
Vol 893 ◽  
pp. 141-144
Author(s):  
Guo Peng
Keyword(s):  
Drug Delivery ◽  
Drug Reaction ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Drug Efficacy ◽  
Delivery Systems ◽  
Current Development ◽  
Redox Responsive ◽  
Targeted Drug ◽  
Design And Construction

At present, more novel smart nanomaterials offering special responses towards some environmental stimuli have been used in the design and construction of rheumatism drug delivery systems to achieve a targeted drug release, thereby improving rheumatism drug efficacy and decreasing adverse rheumatism drug reaction. The current development of the application of pH, photo, thermo, enzyme and redox-responsive smart nanomaterials in rheumatism drug delivery systems was classifiedly reviewed.

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