scholarly journals Polysaccharides for Colon–Targeted Drug Delivery: Improved Drug–Release Specificity and Therapeutic Benefits

10.5772/27138 ◽  
2011 ◽  
Author(s):  
Annette Hartzell ◽  
Devin J.
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Therapeutic Benefits ◽  
Targeted Drug

Programmable shape-morphing microrobots for localized cancer cells treatment

2021 ◽  
Author(s):  
Chen Xin ◽  
Dongdong Jin ◽  
Yanlei Hu ◽  
Liang Yang ◽  
Rui Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Biological Applications ◽  
Proof Of Concept ◽  
Ph Responsive ◽  
Solution Ph ◽  
Shape Morphing ◽  
On Demand ◽  
Targeted Drug

Abstract Microrobots have attracted great attentions due to their wide applications in microobjects manipulation and targeted drug delivery. To realize more complex micro/nano cargos manipulation (e.g., encapsulation and release) in biological applications, endowing microrobots with shapes adaptability with the environment is highly desirable. Here, designable shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rate in a pH-responsive hydrogel. Combined with magnetic propelling, the shape-morphing microcrab (SMMC) is capable of performing targeted microparticle delivery, including gripping, transporting, and releasing through claws morphing. As a proof-of-concept demonstration, the shape-morphing microfish (SMMF) is designed to encapsulate drug (doxorubicin (DOX)) by closing mouth in phosphate buffer saline (PBS, pH~7.4) and release them by opening mouth in slightly acid solution (pH<7), which realize localized Hela cells treatment in an artificial vascular network. These SMMRs with powerful shape morphing capabilities and remote motion controllability provide new platforms for complex microcargos operation and on-demand drug release.

Light-responsive polymersomes with a charge-switch for targeted drug delivery

2020 ◽  
Vol 8 (4) ◽  
pp. 727-735 ◽  
Author(s):  
Yaowu Zhou ◽  
Rongrong Chen ◽  
Huiting Yang ◽  
Chunyan Bao ◽  
Jinyan Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Amphiphilic Polymer ◽  
Targeted Drug ◽  
A Charge

A cationic and lipid-like amphiphilic polymer was designed to form polymersomes for photo-responsive and targeted drug release.

scholarly journals A photochemical approach for controlled drug release in targeted drug delivery

2012 ◽  
Vol 20 (3) ◽  
pp. 1281-1290 ◽  
Author(s):  
Seok Ki Choi ◽  
Manisha Verma ◽  
Justin Silpe ◽  
Ryan E. Moody ◽  
Kenny Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Controlled Drug Release ◽  
Targeted Drug

scholarly journals Multi-stimuli responsive smart chitosan-based microcapsules for targeted drug delivery and triggered drug release

2017 ◽  
Vol 38 ◽  
pp. 145-153 ◽  
Author(s):  
Xuejun Cui ◽  
Xinyu Guan ◽  
Shuangling Zhong ◽  
Jie Chen ◽  
Houjuan Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Stimuli Responsive ◽  
Triggered Drug Release ◽  
Targeted Drug

scholarly journals Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 68 ◽  
Author(s):  
Sang Hoon Lee ◽  
Rajiv Bajracharya ◽  
Jeong Youn Min ◽  
Ji-Won Han ◽  
Byeong Ju Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Local Treatment ◽  
Delivery Systems ◽  
Therapeutic Benefits ◽  
Colonic Drug Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract. In recent years, the global pharmaceutical market for biologics has grown, and increasing demand for a more patient-friendly drug administration system highlights the importance of colonic drug delivery as a noninvasive delivery approach for macromolecules. Colon-targeted drug delivery systems for macromolecules can provide therapeutic benefits including better patient compliance (because they are pain-free and can be self-administered) and lower costs. Therefore, to achieve more efficient colonic drug delivery for local or systemic drug effects, various strategies have been explored including pH-dependent systems, enzyme-triggered systems, receptor-mediated systems, and magnetically-driven systems. In this review, recent advancements in various approaches for designing colon targeted drug delivery systems and their pharmaceutical applications are covered with a particular emphasis on formulation technologies.

scholarly journals A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1970 ◽  
Author(s):  
Humaira Idrees ◽  
Syed Zohaib Javaid Zaidi ◽  
Aneela Sabir ◽  
Rafi Ullah Khan ◽  
Xunli Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Natural Polymer ◽  
Natural Polymers ◽  
Sustained Drug Release ◽  
Delivery Methods ◽  
Lower Toxicity ◽  
Targeted Drug

Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in the pharmaceutical industry. The shortcomings of conventional dosage systems, along with modified and targeted drug delivery methods, are addressed by using polymers with improved bioavailability, biocompatibility, and lower toxicity. Therefore, nanomedicines are now considered to be an innovative type of medication. This review critically examines the use of natural biodegradable polymers and their drug delivery systems for local or targeted and controlled/sustained drug release against fatal diseases.

Boronate-crosslinked polysaccharide conjugates for pH-responsive and targeted drug delivery

2019 ◽  
Vol 55 (8) ◽  
pp. 1164-1167 ◽  
Author(s):  
Yu-Hui Zhang ◽  
Ying-Ming Zhang ◽  
Jie Yu ◽  
Jie Wang ◽  
Yu Liu
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Anticancer Effect ◽  
Targeted Drug

A polysaccharide nanoconjugate was fabricated from N-(2-aminoethyl)-gluconamide-grafted hyaluronic acid and bortezomib, displaying pH-responsive targeted drug release and higher anticancer effect.

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