Label-Free Optical Biochemical Sensors via Liquid-Cladding-Induced Modulation of Waveguide Modes

2017 ◽  
Vol 9 (37) ◽  
pp. 31478-31487 ◽  
Author(s):  
Nhu Hoa Thi Tran ◽  
Jisoo Kim ◽  
Thang Bach Phan ◽  
Sungwon Khym ◽  
Heongkyu Ju
Keyword(s):  
Label Free ◽  
Biochemical Sensors ◽  
Waveguide Modes

scholarly journals Vertically Coupled Polymer Microracetrack Resonators for Label-Free Biochemical Sensors

2012 ◽  
Vol 24 (4) ◽  
pp. 270-272 ◽  
Author(s):  
Camille Delezoide ◽  
Marion Salsac ◽  
Joseph Lautru ◽  
Hervé Leh ◽  
Claude Nogues ◽  
...  
Keyword(s):  
Label Free ◽  
Biochemical Sensors

Optimization of figure of merit in label-free biochemical sensors by designing a ring defect coupled resonator

2014 ◽  
Vol 332 ◽  
pp. 42-49 ◽  
Author(s):  
Lijun Huang ◽  
Huiping Tian ◽  
Daquan Yang ◽  
Jian Zhou ◽  
Qi Liu ◽  
...  
Keyword(s):  
Figure Of Merit ◽  
Label Free ◽  
Biochemical Sensors ◽  
Coupled Resonator

Label-free, mass-sensitive single-molecule imaging using interferometric scattering microscopy

2020 ◽  
Author(s):  
Nikolas Hundt
Keyword(s):  
Single Molecule ◽  
Cellular Systems ◽  
Single Molecule Imaging ◽  
Label Free ◽  
Measurement Sensitivity ◽  
Mass Distributions ◽  
Quantitative Measurements ◽  
Contrast Mechanism ◽  
Cellular Components ◽  
Scattering Signal

Abstract Single-molecule imaging has mostly been restricted to the use of fluorescence labelling as a contrast mechanism due to its superior ability to visualise molecules of interest on top of an overwhelming background of other molecules. Recently, interferometric scattering (iSCAT) microscopy has demonstrated the detection and imaging of single biomolecules based on light scattering without the need for fluorescent labels. Significant improvements in measurement sensitivity combined with a dependence of scattering signal on object size have led to the development of mass photometry, a technique that measures the mass of individual molecules and thereby determines mass distributions of biomolecule samples in solution. The experimental simplicity of mass photometry makes it a powerful tool to analyse biomolecular equilibria quantitatively with low sample consumption within minutes. When used for label-free imaging of reconstituted or cellular systems, the strict size-dependence of the iSCAT signal enables quantitative measurements of processes at size scales reaching from single-molecule observations during complex assembly up to mesoscopic dynamics of cellular components and extracellular protrusions. In this review, I would like to introduce the principles of this emerging imaging technology and discuss examples that show how mass-sensitive iSCAT can be used as a strong complement to other routine techniques in biochemistry.

Computation of waveguide modes for waveguides of arbitrary cross-section

1990 ◽  
Vol 137 (2) ◽  
pp. 145 ◽  
Author(s):  
C.Y. Kim ◽  
S.D. Yu ◽  
R.F. Harrington ◽  
J.W. Ra ◽  
S.Y. Lee
Keyword(s):  
Cross Section ◽  
Arbitrary Cross Section ◽  
Waveguide Modes

Periodic coupling of waveguide modes

1970 ◽  
Vol 117 (11) ◽  
pp. 2061 ◽  
Author(s):  
A.L. Cullen ◽  
O.J. Davies
Keyword(s):  
Waveguide Modes

A microfluidic device with integrated impedance detection for λ-DNA

2003 ◽  
Vol 773 ◽  
Author(s):  
Myung-Il Park ◽  
Jonging Hong ◽  
Dae Sung Yoon ◽  
Chong-Ook Park ◽  
Geunbae Im
Keyword(s):  
Microfluidic Device ◽  
Electrochemical Impedance ◽  
Direct Detection ◽  
Full Potential ◽  
Label Free ◽  
Buffer Solution ◽  
Detection Systems ◽  
Significant Difference ◽  
Detection Of Biomolecules ◽  
Impedance Magnitude

AbstractThe large optical detection systems that are typically utilized at present may not be able to reach their full potential as portable analysis tools. Accurate, early, and fast diagnosis for many diseases requires the direct detection of biomolecules such as DNA, proteins, and cells. In this research, a glass microchip with integrated microelectrodes has been fabricated, and the performance of electrochemical impedance detection was investigated for the biomolecules. We have used label-free λ-DNA as a sample biomolecule. By changing the distance between microelectrodes, the significant difference between DW and the TE buffer solution is obtained from the impedance-frequency measurements. In addition, the comparison for the impedance magnitude of DW, the TE buffer, and λ-DNA at the same distance was analyzed.

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