Stapled RGD Peptide Enables Glioma-Targeted Drug Delivery by Overcoming Multiple Barriers

2017 ◽  
Vol 9 (21) ◽  
pp. 17745-17756 ◽  
Author(s):  
Huitong Ruan ◽  
Xishan Chen ◽  
Cao Xie ◽  
Beibei Li ◽  
Man Ying ◽  
...  
2016 ◽  
Vol 81 (23) ◽  
pp. 11556-11564 ◽  
Author(s):  
Albert Gandioso ◽  
Marc Cano ◽  
Anna Massaguer ◽  
Vicente Marchán

2016 ◽  
Vol 120 (25) ◽  
pp. 5786-5786
Author(s):  
Shewaye Lakew Mekuria ◽  
Tilahun Ayane Debele ◽  
Hsiao-Ying Chou ◽  
Hsieh-Chih Tsai

2012 ◽  
Vol 152-154 ◽  
pp. 683-686 ◽  
Author(s):  
Xiao Hui Li ◽  
Liang Wang ◽  
Jing Yang ◽  
Cun Xian Song

A bolock copolymer of poly(ε-caprolactone) and hyperbranched polyglycidol (PCL-b-HPG) was synthezed by “living” copolymerization of ε-caprolactone (CL) and glycidol. The chemical structure was confirmed by 1H NMR, IR and GPC spectrum. Nanoparticles (NPs) of 50–100 nm were formulated from the PCL-b-HPG copolymer with no evidence of particles aggregation as determined by TEM. RGD peptide was covalently coupled on the end hydroxyl groups that could enable recepter–mediated recongnation onto targeted tissues. In conclusion, a hyperbranched copolymer PCL-b-HPG was synthezed by a novel and simple approach. The numerous functional end-groups could facilitate the attachment of biomolecules for further investigation as targeted drug delivery.


2015 ◽  
Vol 120 (1) ◽  
pp. 123-130 ◽  
Author(s):  
Shewaye Lakew Mekuria ◽  
Tilahun Ayane Debele ◽  
Hsiao-Ying Chou ◽  
Hsieh-Chih Tsai

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