Correction to “IL-6 Antibody and RGD Peptide Conjugated Poly(amidoamine) Dendrimer for Targeted Drug Delivery of HeLa Cells”

2016 ◽  
Vol 120 (25) ◽  
pp. 5786-5786
Author(s):  
Shewaye Lakew Mekuria ◽  
Tilahun Ayane Debele ◽  
Hsiao-Ying Chou ◽  
Hsieh-Chih Tsai
Keyword(s):  
Drug Delivery ◽  
Hela Cells ◽  
Targeted Drug Delivery ◽  
Rgd Peptide ◽  
Targeted Drug

IL-6 Antibody and RGD Peptide Conjugated Poly(amidoamine) Dendrimer for Targeted Drug Delivery of HeLa Cells

2015 ◽  
Vol 120 (1) ◽  
pp. 123-130 ◽  
Author(s):  
Shewaye Lakew Mekuria ◽  
Tilahun Ayane Debele ◽  
Hsiao-Ying Chou ◽  
Hsieh-Chih Tsai
Keyword(s):  
Drug Delivery ◽  
Hela Cells ◽  
Targeted Drug Delivery ◽  
Rgd Peptide ◽  
Targeted Drug

scholarly journals A Green Light-Triggerable RGD Peptide for Photocontrolled Targeted Drug Delivery: Synthesis and Photolysis Studies

2016 ◽  
Vol 81 (23) ◽  
pp. 11556-11564 ◽  
Author(s):  
Albert Gandioso ◽  
Marc Cano ◽  
Anna Massaguer ◽  
Vicente Marchán
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Green Light ◽  
Rgd Peptide ◽  
Targeted Drug

Stapled RGD Peptide Enables Glioma-Targeted Drug Delivery by Overcoming Multiple Barriers

2017 ◽  
Vol 9 (21) ◽  
pp. 17745-17756 ◽  
Author(s):  
Huitong Ruan ◽  
Xishan Chen ◽  
Cao Xie ◽  
Beibei Li ◽  
Man Ying ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Rgd Peptide ◽  
Targeted Drug

scholarly journals Supramolecular nanomotors with “pH taxis” for active drug delivery in the tumor microenvironment

Nanoscale ◽  
2020 ◽  
Vol 12 (44) ◽  
pp. 22495-22501
Author(s):  
Motilal Mathesh ◽  
Jiawei Sun ◽  
Frans van der Sandt ◽  
Daniela A. Wilson
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Hela Cells ◽  
Targeted Drug Delivery ◽  
Active Drug ◽  
Ph Gradient ◽  
Supramolecular Architecture ◽  
Targeted Drug ◽  
Drug Delivery Applications

Supramolecular architecture-based truly “pH taxis” exhibiting nanomotors are fabricated by in-situ grown CaCO3 particles, which can sense the endogenously present pH gradient in HeLa cells making them suitable for targeted drug delivery applications.

Poly(ε-Caprolactone)-b-Hyperbranched Polyglycidol for Targeted Drug Delivery

2012 ◽  
Vol 152-154 ◽  
pp. 683-686 ◽  
Author(s):  
Xiao Hui Li ◽  
Liang Wang ◽  
Jing Yang ◽  
Cun Xian Song
Keyword(s):  
Drug Delivery ◽  
1H Nmr ◽  
Targeted Drug Delivery ◽  
Chemical Structure ◽  
Rgd Peptide ◽  
Simple Approach ◽  
Hydroxyl Groups ◽  
End Groups ◽  
Targeted Drug ◽  
Hyperbranched Copolymer

A bolock copolymer of poly(ε-caprolactone) and hyperbranched polyglycidol (PCL-b-HPG) was synthezed by “living” copolymerization of ε-caprolactone (CL) and glycidol. The chemical structure was confirmed by 1H NMR, IR and GPC spectrum. Nanoparticles (NPs) of 50–100 nm were formulated from the PCL-b-HPG copolymer with no evidence of particles aggregation as determined by TEM. RGD peptide was covalently coupled on the end hydroxyl groups that could enable recepter–mediated recongnation onto targeted tissues. In conclusion, a hyperbranched copolymer PCL-b-HPG was synthezed by a novel and simple approach. The numerous functional end-groups could facilitate the attachment of biomolecules for further investigation as targeted drug delivery.

scholarly journals A Novel Method of Magnetic Nanoparticles Functionalized with Anti-Folate Receptor Antibody and Methotrexate for Antibody Mediated Targeted Drug Delivery

Molecules ◽  
2022 ◽  
Vol 27 (1) ◽  
pp. 261
Author(s):  
Madeeha Shahzad Lodhi ◽  
Fatima Khalid ◽  
Muhammad Tahir Khan ◽  
Zahoor Qadir Samra ◽  
Shabbir Muhammad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Hela Cells ◽  
Targeted Drug Delivery ◽  
Folate Receptor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Folate Receptors ◽  
Receptor Antibody ◽  
Targeted Drug

Therapeutic effects of anticancer medicines can be improved by targeting the specific receptors on cancer cells. Folate receptor (FR) targeting with antibody (Ab) is an effective tool to deliver anticancer drugs to the cancer cell. In this research project, a novel formulation of targeting drug delivery was designed, and its anticancer effects were analyzed. Folic acid-conjugated magnetic nanoparticles (MNPs) were used for the purification of folate receptors through a novel magnetic affinity purification method. Antibodies against the folate receptors and methotrexate (MTX) were developed and characterized with enzyme-linked immunosorbent assay and Western blot. Targeting nanomedicines (MNP-MTX-FR Ab) were synthesized by engineering the MNP with methotrexate and anti-folate receptor antibody (anti-FR Ab). The cytotoxicity of nanomedicines on HeLa cells was analyzed by calculating the % age cell viability. A fluorescent study was performed with HeLa cells and tumor tissue sections to analyze the binding efficacy and intracellular tracking of synthesized nanomedicines. MNP-MTX-FR Ab demonstrated good cytotoxicity along all the nanocomposites, which confirms that the antibody-coated medicine possesses the potential affinity to destroy cancer cells in the targeted drug delivery process. Immunohistochemical approaches and fluorescent study further confirmed their uptake by FRs on the tumor cells’ surface in antibody-mediated endocytosis. The current approach is a useful addition to targeted drug delivery for better management of cancer therapy along with immunotherapy in the future.

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