Assessing the Biocidal Activity and Investigating the Mechanism of Oligo-p-phenylene-ethynylenes

2017 ◽  
Vol 9 (9) ◽  
pp. 7964-7971 ◽  
Author(s):  
Jing Wang ◽  
Liangang Zhuo ◽  
Wei Liao ◽  
Xia Yang ◽  
Zhenghua Tang ◽  
...  
Keyword(s):  
Biocidal Activity ◽  
Phenylene Ethynylenes

scholarly journals Antifungal Properties of Cationic Phenylene Ethynylenes and Their Impact on β-Glucan Exposure

2016 ◽  
Vol 60 (8) ◽  
pp. 4519-4529 ◽  
Author(s):  
Harry C. Pappas ◽  
Rina Sylejmani ◽  
Matthew S. Graus ◽  
Patrick L. Donabedian ◽  
David G. Whitten ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Membrane Integrity ◽  
Significant Risk ◽  
Yeast Cells ◽  
Size Difference ◽  
Phenylene Ethynylene ◽  
Biocidal Activity ◽  
Content Type ◽  
Antifungal Properties ◽  
Phenylene Ethynylenes

ABSTRACTCandidaspecies are the cause of many bloodstream infections through contamination of indwelling medical devices. These infections account for a 40% mortality rate, posing a significant risk to immunocompromised patients. Traditional treatments againstCandidainfections include amphotericin B and various azole treatments. Unfortunately, these treatments are associated with high toxicity, and resistant strains have become more prevalent. As a new frontier, light-activated phenylene ethynylenes have shown promising biocidal activity against Gram-positive and -negative bacterial pathogens, as well as the environmental yeastSaccharomyces cerevisiae. In this study, we monitored the viability ofCandidaspecies after treatment with a cationic conjugated polymer [poly(p-phenylene ethynylene); PPE] or oligomer [“end-only” oligo(p-phenylene ethynylene); EO-OPE] by flow cytometry in order to explore the antifungal properties of these compounds. The oligomer was found to disruptCandida albicansyeast membrane integrity independent of light activation, while PPE is able to do so only in the presence of light, allowing for some control as to the manner in which cytotoxic effects are induced. The contrast in killing efficacy between the two compounds is likely related to their size difference and their intrinsic abilities to penetrate the fungal cell wall. Unlike EO-OPE-DABCO (where DABCO is quaternized diazabicyclo[2,2,2]octane), PPE-DABCO displayed a strong propensity to associate with soluble β-glucan, which is expected to inhibit its ability to access and perturb the inner cell membrane ofCandidayeast. Furthermore, treatment with PPE-DABCO unmaskedCandida albicansβ-glucan and increased phagocytosis by Dectin-1-expressing HEK-293 cells. In summary, cationic phenylene ethynylenes show promising biocidal activity against pathogenicCandidayeast cells while also exhibiting immunostimulatory effects.

Biocidal Activity and Mechanism Study of Unsymmetrical Oligo-Phenylene-Ethynylenes

2020 ◽  
Vol 3 (9) ◽  
pp. 5644-5651
Author(s):  
Wei Liao ◽  
Lian-gang Zhuo ◽  
Xia Yang ◽  
Peng Zhao ◽  
Wentao Kan ◽  
...  
Keyword(s):  
Mechanism Study ◽  
Biocidal Activity ◽  
Phenylene Ethynylenes

Synthesis of Some Novel Sulfonamide Derivatives and Investigating their Biocidal Activity in Cooling Towers

2011 ◽  
Vol 48 (2) ◽  
pp. 154-159 ◽  
Author(s):  
A. M. Badawi ◽  
D. E. Mohamed ◽  
A. A. Hafiz ◽  
S. M. Ahmed ◽  
Y. M. Gohar ◽  
...  
Keyword(s):  
Cooling Towers ◽  
Biocidal Activity

scholarly journals Microbial Toxins in Insect and Nematode Pest Biocontrol

2021 ◽  
Vol 22 (14) ◽  
pp. 7657
Author(s):  
Subbaiah Chalivendra
Keyword(s):  
Environmental Safety ◽  
Control Measures ◽  
Biocidal Activity ◽  
Transgenic Expression ◽  
Direct Injury ◽  
Pathogenic Microbes ◽  
Synthetic Pesticides ◽  
Invertebrate Pests ◽  
Livestock Diseases ◽  
Microbial Toxins

Invertebrate pests, such as insects and nematodes, not only cause or transmit human and livestock diseases but also impose serious crop losses by direct injury as well as vectoring pathogenic microbes. The damage is global but greater in developing countries, where human health and food security are more at risk. Although synthetic pesticides have been in use, biological control measures offer advantages via their biodegradability, environmental safety and precise targeting. This is amply demonstrated by the successful and widespread use of Bacillusthuringiensis to control mosquitos and many plant pests, the latter by the transgenic expression of insecticidal proteins from B. thuringiensis in crop plants. Here, I discuss the prospects of using bacterial and fungal toxins for pest control, including the molecular basis of their biocidal activity.

Antimicrobial Peptide-Loaded Pectolite Nanorods for Enhancing Wound-Healing and Biocidal Activity of Titanium

2021 ◽  
Author(s):  
Lan Zhang ◽  
Yang Xue ◽  
Sanjana Gopalakrishnan ◽  
Kai Li ◽  
Yong Han ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antimicrobial Peptide ◽  
Biocidal Activity

scholarly journals Synthesis and Biocidal Activity of Some Naphthalene-Based Cationic Surfactants

2011 ◽  
Vol 15 (2) ◽  
pp. 223-234 ◽  
Author(s):  
Ismail A. Aiad ◽  
Abdelfatah M. Badawi ◽  
Mohammed M. El-Sukkary ◽  
Abdallah A. El-Sawy ◽  
Ahmed I. Adawy
Keyword(s):  
Cationic Surfactants ◽  
Biocidal Activity

Fluorescence quenching of a poly(para-phenylene ethynylenes) by C60 fullerenes

2012 ◽  
Vol 249 ◽  
pp. 41-46 ◽  
Author(s):  
Katie Campbell ◽  
Andrew Zappas ◽  
Uwe Bunz ◽  
Yonathan S. Thio ◽  
David G. Bucknall
Keyword(s):  
Fluorescence Quenching ◽  
Phenylene Ethynylenes ◽  
C60 Fullerenes

Fluorescence Study of Energy Transfer in PMMA Polymers with Pendant Oligo-Phenylene-Ethynylenes

ChemPhysChem ◽  
2012 ◽  
Vol 14 (1) ◽  
pp. 170-178 ◽  
Author(s):  
Johann Schäfer ◽  
Alexander Breul ◽  
Eckard Birckner ◽  
Martin D. Hager ◽  
Ulrich S. Schubert ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Fluorescence Study ◽  
Phenylene Ethynylenes
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