Biocidal Activity and Mechanism Study of Unsymmetrical Oligo-Phenylene-Ethynylenes

2020 ◽  
Vol 3 (9) ◽  
pp. 5644-5651
Author(s):  
Wei Liao ◽  
Lian-gang Zhuo ◽  
Xia Yang ◽  
Peng Zhao ◽  
Wentao Kan ◽  
...  
Keyword(s):  
Mechanism Study ◽  
Biocidal Activity ◽  
Phenylene Ethynylenes

Assessing the Biocidal Activity and Investigating the Mechanism of Oligo-p-phenylene-ethynylenes

2017 ◽  
Vol 9 (9) ◽  
pp. 7964-7971 ◽  
Author(s):  
Jing Wang ◽  
Liangang Zhuo ◽  
Wei Liao ◽  
Xia Yang ◽  
Zhenghua Tang ◽  
...  
Keyword(s):  
Biocidal Activity ◽  
Phenylene Ethynylenes

scholarly journals Antifungal Properties of Cationic Phenylene Ethynylenes and Their Impact on β-Glucan Exposure

2016 ◽  
Vol 60 (8) ◽  
pp. 4519-4529 ◽  
Author(s):  
Harry C. Pappas ◽  
Rina Sylejmani ◽  
Matthew S. Graus ◽  
Patrick L. Donabedian ◽  
David G. Whitten ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Membrane Integrity ◽  
Significant Risk ◽  
Yeast Cells ◽  
Size Difference ◽  
Phenylene Ethynylene ◽  
Biocidal Activity ◽  
Content Type ◽  
Antifungal Properties ◽  
Phenylene Ethynylenes

ABSTRACTCandidaspecies are the cause of many bloodstream infections through contamination of indwelling medical devices. These infections account for a 40% mortality rate, posing a significant risk to immunocompromised patients. Traditional treatments againstCandidainfections include amphotericin B and various azole treatments. Unfortunately, these treatments are associated with high toxicity, and resistant strains have become more prevalent. As a new frontier, light-activated phenylene ethynylenes have shown promising biocidal activity against Gram-positive and -negative bacterial pathogens, as well as the environmental yeastSaccharomyces cerevisiae. In this study, we monitored the viability ofCandidaspecies after treatment with a cationic conjugated polymer [poly(p-phenylene ethynylene); PPE] or oligomer [“end-only” oligo(p-phenylene ethynylene); EO-OPE] by flow cytometry in order to explore the antifungal properties of these compounds. The oligomer was found to disruptCandida albicansyeast membrane integrity independent of light activation, while PPE is able to do so only in the presence of light, allowing for some control as to the manner in which cytotoxic effects are induced. The contrast in killing efficacy between the two compounds is likely related to their size difference and their intrinsic abilities to penetrate the fungal cell wall. Unlike EO-OPE-DABCO (where DABCO is quaternized diazabicyclo[2,2,2]octane), PPE-DABCO displayed a strong propensity to associate with soluble β-glucan, which is expected to inhibit its ability to access and perturb the inner cell membrane ofCandidayeast. Furthermore, treatment with PPE-DABCO unmaskedCandida albicansβ-glucan and increased phagocytosis by Dectin-1-expressing HEK-293 cells. In summary, cationic phenylene ethynylenes show promising biocidal activity against pathogenicCandidayeast cells while also exhibiting immunostimulatory effects.

Assemblies of D-peptides for Targeting Cell Nucleolus

2019 ◽  
Author(s):  
Huaimin Wang ◽  
Zhaoqianqi Feng ◽  
Weiyi Tan ◽  
Bing Xu
Keyword(s):  
Particle Morphology ◽  
Side Chain ◽  
Mechanism Study ◽  
Structural Analogue ◽  
Hydrophobic Residues ◽  
Subcellular Organelles ◽  
First Case ◽  
New Strategy ◽  
Peptide Derivative ◽  
Peptide Nanoparticles

<p>Selectively targeting cell nucleolus remains a challenge. Here we report the first case that D-peptides form membraneless molecular condensates with RNA for targeting cell nucleolus. A D-peptide derivative, enriched with lysine and hydrophobic residues, self-assembles to form nanoparticles, which enter cells through clathrin dependent endocytosis and mainly accumulate at cell nucleolus. Structural analogue of the D-peptide reveals that particle morphology of the assemblies, which depends on the side chain modification, favors the cellular uptake. Contrasting to those of the D-peptide, the assemblies of the corresponding L-enantiomer largely localize in cell lysosomes. Preliminary mechanism study suggests that the D-peptide nanoparticles interact with RNA to form membraneless condensates in the nucleolus, which further induces DNA damage and results in cell death. This work illustrates a new strategy for rationally designing supramolecular assemblies of D-peptides for targeting subcellular organelles.</p>

Synthesis of Some Novel Sulfonamide Derivatives and Investigating their Biocidal Activity in Cooling Towers

2011 ◽  
Vol 48 (2) ◽  
pp. 154-159 ◽  
Author(s):  
A. M. Badawi ◽  
D. E. Mohamed ◽  
A. A. Hafiz ◽  
S. M. Ahmed ◽  
Y. M. Gohar ◽  
...  
Keyword(s):  
Cooling Towers ◽  
Biocidal Activity

Formononetin Ameliorates Cognitive Disorder via PGC-1α Pathway in Neuroinflammation Conditions in High-Fat Diet-Induced Mice

2019 ◽  
Vol 18 (7) ◽  
pp. 566-577 ◽  
Author(s):  
Xinxin Fu ◽  
Tingting Qin ◽  
Jiayu Yu ◽  
Jie Jiao ◽  
Zhanqiang Ma ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Fat Diet ◽  
Trifolium Pratense ◽  
Amyloid Β ◽  
Cognitive Disorder ◽  
Mechanism Study ◽  
High Fat ◽  
Neuroprotective Effects ◽  
Underlying Mechanisms

Background: Alzheimer’s disease is one of the most common neurodegenerative diseases in many modern societies. The core pathogenesis of Alzheimer’s disease includes the aggregation of hyperphosphorylated Tau and abnormal Amyloid-β generation. In addition, previous studies have shown that neuroinflammation is one of the pathogenesis of Alzheimer’s disease. Formononetin, an isoflavone compound extracted from Trifolium pratense L., has been found to have various properties including anti-obesity, anti-inflammation, and neuroprotective effects. But there are very few studies on the treatment of Alzheimer’s disease with Formononetin. Objective: The present study focused on the protective activities of Formononetin on a high-fat dietinduced cognitive decline and explored the underlying mechanisms. Methods: Mice were fed with HFD for 10 weeks and intragastric administrated daily with metformin (300 mg/kg) and Formononetin (20 and 40 mg/kg). Results: We found that Formononetin (20, 40 mg/kg) significantly attenuated the learning and memory deficits companied by weight improvement and decreased the levels of blood glucose, total cholesterol and triglyceride in high-fat diet-induced mice. Meanwhile, we observed high-fat diet significantly caused the Tau hyperphosphorylation in the hippocampus of mice, whereas Formononetin reversed this effect. Additionally, Formononetin markedly reduced the levels of inflammation cytokines IL-1β and TNF-α in high-fat diet-induced mice. The mechanism study showed that Formononetin suppressed the pro-inflammatory NF-κB signaling and enhanced the anti-inflammatory Nrf-2/HO-1 signaling, which might be related to the regulation of PGC-1α in the hippocampus of high-fat diet -induced mice. Conclusion: Taken together, our results showed that Formononetin could improve the cognitive function by inhibiting neuroinflammation, which is attributed to the regulation of PGC-1α pathway in HFD-induced mice.

AC conductivity and conduction mechanism study of rubidium gadolinium diphosphate compound

2018 ◽  
Vol 93 (5) ◽  
pp. 603-610 ◽  
Author(s):  
Samia Mathlouthi ◽  
Abderrazek Oueslati ◽  
Bassem Louati
Keyword(s):  
Ac Conductivity ◽  
Conduction Mechanism ◽  
Mechanism Study

Regioselective Thermal Reaction between Triethylamine and C60Revisited: X-ray Confirmation of the Pentane-Fused Adduct and in Situ Mechanism Study

2015 ◽  
Vol 2015 (26) ◽  
pp. 5742-5746 ◽  
Author(s):  
Muqing Chen ◽  
Wangqiang Shen ◽  
Lipiao Bao ◽  
Wenting Cai ◽  
Yunpeng Xie ◽  
...  
Keyword(s):  
Thermal Reaction ◽  
Mechanism Study ◽  
X Ray
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