Strontium-Doped Amorphous Calcium Phosphate Porous Microspheres Synthesized through a Microwave-Hydrothermal Method Using Fructose 1,6-Bisphosphate as an Organic Phosphorus Source: Application in Drug Delivery and Enhanced Bone Regeneration

2017 ◽  
Vol 9 (4) ◽  
pp. 3306-3317 ◽  
Author(s):  
Weilin Yu ◽  
Tuan-Wei Sun ◽  
Chao Qi ◽  
Zhenyu Ding ◽  
Huakun Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Hydrothermal Method ◽  
Amorphous Calcium Phosphate ◽  
Organic Phosphorus ◽  
Microwave Hydrothermal ◽  
Microwave Hydrothermal Method ◽  
Phosphorus Source ◽  
Fructose 1,6 Bisphosphate

Amorphous magnesium phosphate flower-like hierarchical nanostructures: microwave-assisted rapid synthesis using fructose 1,6-bisphosphate trisodium salt as an organic phosphorus source and application in protein adsorption

RSC Advances ◽  
2015 ◽  
Vol 5 (19) ◽  
pp. 14906-14915 ◽  
Author(s):  
Chao Qi ◽  
Ying-Jie Zhu ◽  
Bing-Qiang Lu ◽  
Jin Wu ◽  
Feng Chen
Keyword(s):  
Organic Phosphorus ◽  
Magnesium Phosphate ◽  
Rapid Synthesis ◽  
Hierarchical Nanostructures ◽  
Microwave Assisted ◽  
Microwave Hydrothermal ◽  
Microwave Hydrothermal Method ◽  
Phosphorus Source ◽  
Trisodium Salt ◽  
Fructose 1,6 Bisphosphate

Amorphous magnesium phosphate flower-like hierarchical nanostructures are synthesized using fructose 1,6-bisphosphate trisodium salt by the microwave hydrothermal method.

Magnesium whitlockite hollow microspheres: a comparison of microwave-hydrothermal and conventional hydrothermal syntheses using fructose 1,6-bisphosphate, and application in protein adsorption

RSC Advances ◽  
2016 ◽  
Vol 6 (40) ◽  
pp. 33393-33402 ◽  
Author(s):  
Chao Qi ◽  
Feng Chen ◽  
Jin Wu ◽  
Ying-Jie Zhu ◽  
Chang-Ning Hao ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Adsorption Capacity ◽  
Hydrothermal Method ◽  
Hollow Microspheres ◽  
Hydrothermal Syntheses ◽  
Microwave Hydrothermal ◽  
Microwave Hydrothermal Method ◽  
Fructose 1,6 Bisphosphate

Magnesium whitlockite hollow microspheres with high biocompatibility and protein adsorption capacity are synthesized by a rapid microwave-hydrothermal method using fructose 1,6-bisphosphate.

scholarly journals Amorphous calcium phosphate nanoparticles using adenosine triphosphate as an organic phosphorus source for promoting tendon–bone healing

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Haoran Liao ◽  
Han-Ping Yu ◽  
Wei Song ◽  
Guangcheng Zhang ◽  
Bingqiang Lu ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Rotator Cuff ◽  
Adenosine Triphosphate ◽  
Bone Healing ◽  
Amorphous Calcium Phosphate ◽  
Organic Phosphorus ◽  
Biological Activities ◽  
Phosphorus Source

Abstract Background Rotator cuff tear (RCT) is a common problem of the musculoskeletal system. With the advantage of promoting bone formation, calcium phosphate materials have been widely used to augment tendon-bone healing. However, only enhancing bone regeneration may be not enough for improving tendon–bone healing. Angiogenesis is another fundamental factor required for tendon–bone healing. Therefore, it’s necessary to develop a convenient and reliable method to promote osteogenesis and angiogenesis simultaneously, thereby effectively promoting tendon–bone healing. Methods The amorphous calcium phosphate (ACP) nanoparticles with dual biological activities of osteogenesis and angiogenesis were prepared by a simple low-temperature aqueous solution method using adenosine triphosphate (ATP) as an organic phosphorus source. The activities of osteogenesis and angiogenesis and the effect on the tendon–bone healing of ACP nanoparticles were tested in vitro and in a rat model of acute RCT. Results The ACP nanoparticles with a diameter of tens of nanometers were rich in bioactive adenosine. In vitro, we confirmed that ACP nanoparticles could enhance osteogenesis and angiogenesis. In vivo, radiological and histological evaluations demonstrated that ACP nanoparticles could enhance bone and blood vessels formation at the tendon–bone junction. Biomechanical testing showed that ACP nanoparticles improved the biomechanical strength of the tendon–bone junction and ultimately promoted tendon–bone healing of rotator cuff. Conclusions We successfully confirmed that ACP nanoparticles could promote tendon–bone healing. ACP nanoparticles are a promising biological nanomaterial in augmenting tendon–bone healing. Graphic abstract

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