CaCO3/Tetraethylenepentamine–Graphene Hollow Microspheres as Biocompatible Bone Drug Carriers for Controlled Release

2016 ◽  
Vol 8 (44) ◽  
pp. 30027-30036 ◽  
Author(s):  
Jie Li ◽  
Hongkun Jiang ◽  
Xiao Ouyang ◽  
Shihui Han ◽  
Jun Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Carriers ◽  
Hollow Microspheres

scholarly journals Preparation and Sustained-Release Performance of PLGA Microcapsule Carrier System

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1758
Author(s):  
Shuaikai Ren ◽  
Chunxin Wang ◽  
Liang Guo ◽  
Congcong Xu ◽  
Yan Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Biomedical Applications ◽  
Encapsulation Efficiency ◽  
Drug Carriers ◽  
Optimum Conditions ◽  
Carrier System ◽  
Preparation Conditions ◽  
Encapsulation Rate ◽  
Release Drug ◽  
Release Curve

Microcapsules have been widely studied owing to their biocompatibility and potential for application in various areas, particularly drug delivery. However, the size of microcapsules is difficult to control, and the size distribution is very broad via various encapsulation techniques. Therefore, it is necessary to obtain microcapsules with uniform and tailored size for the construction of controlled-release drug carriers. In this study, emulsification and solvent evaporation methods were used to prepare a variety of ovalbumin-loaded poly (lactic-co-glycolic acid) (PLGA) microcapsules to determine the optimal preparation conditions. The particle size of the PLGA microcapsules prepared using the optimum conditions was approximately 200 nm, which showed good dispersibility with an ovalbumin encapsulation rate of more than 60%. In addition, porous microcapsules with different pore sizes were prepared by adding a varying amount of porogen bovine serum albumin (BSA) to the internal water phase. The release curve showed that the rate of protein release from the microcapsules could be controlled by adjusting the pore size. These findings demonstrated that we could tailor the morphology and structure of microcapsules by regulating the preparation conditions, thus controlling the encapsulation efficiency and the release performance of the microcapsule carrier system. We envision that this controlled-release novel microcapsule carrier system shows great potential for biomedical applications.

scholarly journals Fabrication of Flocculation-Resistant pH/Ionic Strength/Temperature Multiresponsive Hollow Microspheres and Their Controlled Release

2011 ◽  
Vol 9 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Bin Mu ◽  
Peng Liu ◽  
Xiaorui Li ◽  
Pengcheng Du ◽  
Yun Dong ◽  
...  
Keyword(s):  
Ionic Strength ◽  
Controlled Release ◽  
Hollow Microspheres

Development and Characterization of Chitosan Membranes as a System for Controlled Release of Piperine

2016 ◽  
Vol 869 ◽  
pp. 864-868
Author(s):  
Imarally Vitor de Souza Ribeiro Nascimento ◽  
Mairly Karolyne da Silva Souza ◽  
Willams Teles Barbosa ◽  
Thiago Bizerra Fideles ◽  
Thais Maria Alves Marinho ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Carriers ◽  
Solvent Casting ◽  
X Ray Diffraction ◽  
Casting Method ◽  
Pharmacological Activities ◽  
X Ray ◽  
Natural Alkaloid ◽  
Chitosan Membranes

Among the variety of polymers used as drug carriers, chitosan has received attention in the fields of medicine and pharmacy by being a nontoxic, biocompatible and biodegradable copolymer. Piperine is a natural alkaloid, has various pharmacological activities such as anti-inflammatory, analgesic, antipyretic, hepatoprotective and antitumor when combined with chitosan has better bioavailability and more effectiveness. This work aims to prepare and characterize chitosan / piperine membranes obtained by the solvent casting method. The membranes were characterized by Spectroscopy Fourier Transform Infrared (FTIR), X-ray Diffraction (DRX) and Scanning Electron Microscopy (MEV). From the results obtained it can be concluded that the process described was effective in obtaining the system chitosan/piperine indicating its potential for studies of controlled release of drug.

scholarly journals Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics

2019 ◽  
Vol 69 (12) ◽  
pp. 3400-3405
Author(s):  
Mariana Mateescu ◽  
Sanda Maria Doncea ◽  
Iuliana Raut ◽  
Cristina Lavinia Nistor ◽  
Ioneta Codrina Bujanca
Keyword(s):  
Controlled Release ◽  
Biomedical Application ◽  
Drug Loading ◽  
Antibacterial Properties ◽  
Drug Carriers ◽  
Chemical Precipitation ◽  
Controlled Delivery ◽  
Wet Chemical ◽  
Uv Visible ◽  
Wet Chemical Precipitation

The hydroxyapatite (HA) nano and microparticles were synthesized by wet-chemical precipitation in order to use them as drug carriers for biomedical applications. Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS) and Fourier Transform Infrared Spectroscopy (FTIR) were performed to assess their size, external morphology and chemical composition. The properties of HA particles as drug carriers for antibiotics delivery were evaluated with doxycycline and chloramphenicol. The amount of drug loading and release was determined by UV-Visible spectrophotometry. The antibacterial properties of loaded HA particles were evaluated using gram-positive Bacillus subtilis bacteria and gram-negative Pseudomonas aeruginosa bacteria. The synthesized particles of HA exhibit a high adsorption capacity (around 99%) and good controlled release properties for doxycycline. The adsorption of chloramphenicol on HA was extremely low (about 2%). According to the results, the compatibility between the drug and substrate is an important factor in the absorption process, and the hydroxyapatite is a very promising carrier for controlled release of antibiotics.

scholarly journals Controlled release of entrapped nanoparticles from thermoresponsive hydrogels with tunable network characteristics

Soft Matter ◽  
2020 ◽  
Vol 16 (20) ◽  
pp. 4756-4766 ◽  
Author(s):  
Yi Wang ◽  
Zhen Li ◽  
Jie Ouyang ◽  
George Em Karniadakis
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Network Characteristics ◽  
Thermoresponsive Hydrogels ◽  
Smart Drug

Thermoresponsive hydrogels have been studied intensively for creating smart drug carriers and controlled drug delivery.

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