Electrospun poly(N-isopropylacrylamide)/poly(caprolactone)-based polyurethane nanofibers as drug carriers and temperature-controlled release

2013 ◽  
Vol 37 (8) ◽  
pp. 2433 ◽  
Author(s):  
Xiuling Lin ◽  
Dongyan Tang ◽  
Shuo Gu ◽  
Haofei Du ◽  
Enying Jiang
Keyword(s):  
Controlled Release ◽  
Drug Carriers ◽  
Temperature Controlled ◽  
Poly Caprolactone

scholarly journals Preparation and Sustained-Release Performance of PLGA Microcapsule Carrier System

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1758
Author(s):  
Shuaikai Ren ◽  
Chunxin Wang ◽  
Liang Guo ◽  
Congcong Xu ◽  
Yan Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Biomedical Applications ◽  
Encapsulation Efficiency ◽  
Drug Carriers ◽  
Optimum Conditions ◽  
Carrier System ◽  
Preparation Conditions ◽  
Encapsulation Rate ◽  
Release Drug ◽  
Release Curve

Microcapsules have been widely studied owing to their biocompatibility and potential for application in various areas, particularly drug delivery. However, the size of microcapsules is difficult to control, and the size distribution is very broad via various encapsulation techniques. Therefore, it is necessary to obtain microcapsules with uniform and tailored size for the construction of controlled-release drug carriers. In this study, emulsification and solvent evaporation methods were used to prepare a variety of ovalbumin-loaded poly (lactic-co-glycolic acid) (PLGA) microcapsules to determine the optimal preparation conditions. The particle size of the PLGA microcapsules prepared using the optimum conditions was approximately 200 nm, which showed good dispersibility with an ovalbumin encapsulation rate of more than 60%. In addition, porous microcapsules with different pore sizes were prepared by adding a varying amount of porogen bovine serum albumin (BSA) to the internal water phase. The release curve showed that the rate of protein release from the microcapsules could be controlled by adjusting the pore size. These findings demonstrated that we could tailor the morphology and structure of microcapsules by regulating the preparation conditions, thus controlling the encapsulation efficiency and the release performance of the microcapsule carrier system. We envision that this controlled-release novel microcapsule carrier system shows great potential for biomedical applications.

scholarly journals Drug release from thin films encapsulated by a temperature-responsive hydrogel

Soft Matter ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. 1853-1859 ◽  
Author(s):  
Oliver Werzer ◽  
Stephan Tumphart ◽  
Roman Keimel ◽  
Paul Christian ◽  
Anna Maria Coclite
Keyword(s):  
Thin Films ◽  
Controlled Release ◽  
Drug Release ◽  
Temperature Responsive ◽  
Temperature Controlled ◽  
Drug Polymer Interaction ◽  
Polymer Interaction

Temperature-controlled release and study on the effects of the drug–polymer interaction and pH.

Development and Characterization of Chitosan Membranes as a System for Controlled Release of Piperine

2016 ◽  
Vol 869 ◽  
pp. 864-868
Author(s):  
Imarally Vitor de Souza Ribeiro Nascimento ◽  
Mairly Karolyne da Silva Souza ◽  
Willams Teles Barbosa ◽  
Thiago Bizerra Fideles ◽  
Thais Maria Alves Marinho ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Carriers ◽  
Solvent Casting ◽  
X Ray Diffraction ◽  
Casting Method ◽  
Pharmacological Activities ◽  
X Ray ◽  
Natural Alkaloid ◽  
Chitosan Membranes

Among the variety of polymers used as drug carriers, chitosan has received attention in the fields of medicine and pharmacy by being a nontoxic, biocompatible and biodegradable copolymer. Piperine is a natural alkaloid, has various pharmacological activities such as anti-inflammatory, analgesic, antipyretic, hepatoprotective and antitumor when combined with chitosan has better bioavailability and more effectiveness. This work aims to prepare and characterize chitosan / piperine membranes obtained by the solvent casting method. The membranes were characterized by Spectroscopy Fourier Transform Infrared (FTIR), X-ray Diffraction (DRX) and Scanning Electron Microscopy (MEV). From the results obtained it can be concluded that the process described was effective in obtaining the system chitosan/piperine indicating its potential for studies of controlled release of drug.

scholarly journals Microscale Polymer Bottles Corked with a Phase-Change Material for Temperature-Controlled Release

2013 ◽  
Vol 52 (40) ◽  
pp. 10468-10471 ◽  
Author(s):  
Dong Choon Hyun ◽  
Ping Lu ◽  
Sang-Il Choi ◽  
Unyong Jeong ◽  
Younan Xia
Keyword(s):  
Controlled Release ◽  
Phase Change ◽  
Phase Change Material ◽  
Temperature Controlled ◽  
Change Material
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