pH-Responsive Nanometric Polydiacetylenic Micelles Allow for Efficient Intracellular siRNA Delivery

2016 ◽  
Vol 8 (45) ◽  
pp. 30665-30670 ◽  
Author(s):  
Manon Ripoll ◽  
Patrick Neuberg ◽  
Antoine Kichler ◽  
Nassera Tounsi ◽  
Alain Wagner ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Ph Responsive

pH-responsive hybrid quantum dots for targeting hypoxic tumor siRNA delivery

2015 ◽  
Vol 220 ◽  
pp. 529-544 ◽  
Author(s):  
HongYan Zhu ◽  
ShengYu Zhang ◽  
Yong Ling ◽  
GuoLiang Meng ◽  
Yu Yang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Sirna Delivery ◽  
Ph Responsive ◽  
Hypoxic Tumor

scholarly journals Breathing Life into Polycations:  Functionalization with pH-Responsive Endosomolytic Peptides and Polyethylene Glycol Enables siRNA Delivery

2008 ◽  
Vol 130 (11) ◽  
pp. 3272-3273 ◽  
Author(s):  
Martin Meyer ◽  
Alexander Philipp ◽  
Reza Oskuee ◽  
Claudia Schmidt ◽  
Ernst Wagner
Keyword(s):  
Polyethylene Glycol ◽  
Sirna Delivery ◽  
Ph Responsive

scholarly journals Strontium Sulfite: A New pH-Responsive Inorganic Nanocarrier to Deliver Therapeutic siRNAs to Cancer Cells

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 89 ◽  
Author(s):  
Md. Karim ◽  
Jayalaxmi Shetty ◽  
Rowshan Islam ◽  
Ahsanul Kaiser ◽  
Athirah Bakhtiar ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Regression ◽  
Sirna Delivery ◽  
Particle Growth ◽  
Inorganic Nanoparticles ◽  
Ph Responsive ◽  
Growth Inhibition Assay ◽  
Cancer Cell Death ◽  
Biodistribution Studies

Inorganic nanoparticles hold great potential in the area of precision medicine, particularly for treating cancer owing to their unique physicochemical properties, biocompatibility and improved pharmacokinetics properties compared to their organic counterparts. Here we introduce strontium sulfite nanoparticles as new pH-responsive inorganic nanocarriers for efficient transport of siRNAs into breast cancer cells. We employed the simplest nanoprecipitation method to generate the strontium sulfite nanoparticles (SSNs) and demonstrated the dramatic roles of NaCl and d-glucose in particle growth stabilization in order to produce even smaller nanosize particles (Na-Glc-SSN) with high affinity towards negatively charged siRNA, enabling it to efficiently enter the cancer cells. Moreover, the nanoparticles were found to be degraded with a small drop in pH, suggesting their potential capability to undergo rapid dissolution at endosomal pH so as to release the payload. While these particles were found to be nontoxic to the cells, they showed higher potency in facilitating cancer cell death through intracellular delivery and release of oncogene-specific siRNAs targeting ros1 and egfr1 mRNA transcripts, than the strontium sulfite particles prepared in absence of NaCl and d-glucose, as confirmed by growth inhibition assay. The mouse plasma binding analysis by Q-TOF LC-MS/MS demonstrated less protein binding to smaller particles of Na-Glc-SSNs. The biodistribution studies of the particles after 4 h of treatment showed Na-Glc-SSNs had less off-target distribution than SSNs, and after 24 h, all siRNAs were cleared from all major organs except the tumors. ROS1 siRNA with its potential therapeutic role in treating 4T1-induced breast tumor was selected for subsequent in vivo tumor regression study, revealing that ROS1 siRNA-loaded SSNs exerted more significant anti-tumor effects than Na-Glc-SSNs carrying the same siRNA following intravenous administration, without any systemic toxicity. Thus, strontium sulfite emerged as a powerful siRNA delivery tool with potential applications in cancer gene therapy.

Key determinants of siRNA delivery mediated by unique pH-responsive lipid-based liposomes

2019 ◽  
Vol 569 ◽  
pp. 118606 ◽  
Author(s):  
Mariko Sako ◽  
Furan Song ◽  
Ayaka Okamoto ◽  
Hiroyuki Koide ◽  
Takehisa Dewa ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Ph Responsive

scholarly journals The Effects of Biological Fluids on Colloidal Stability and siRNA Delivery of a pH-Responsive Micellar Nanoparticle Delivery System

ACS Nano ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 187-197 ◽  
Author(s):  
Dominic W. Malcolm ◽  
Jomy J. Varghese ◽  
Janet E. Sorrells ◽  
Catherine E. Ovitt ◽  
Danielle S. W. Benoit
Keyword(s):  
Delivery System ◽  
Colloidal Stability ◽  
Biological Fluids ◽  
Sirna Delivery ◽  
Ph Responsive ◽  
Nanoparticle Delivery

scholarly journals Responsive pentablock copolymers for siRNA delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (54) ◽  
pp. 43515-43527 ◽  
Author(s):  
Metin Uz ◽  
Surya K. Mallapragada ◽  
Sacide Alsoy Altinkaya
Keyword(s):  
Sirna Delivery ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Pentablock Copolymers ◽  
First Time

Temperature and pH responsive pentablock copolymers were used for the first time in developing polyplex and multicomponent siRNA delivery systems.

Charge-reversible lipid derivative: A novel type of pH-responsive lipid for nanoparticle-mediated siRNA delivery

2020 ◽  
Vol 585 ◽  
pp. 119479 ◽  
Author(s):  
Yusuke Hirai ◽  
Ryoko Saeki ◽  
Furan Song ◽  
Hiroyuki Koide ◽  
Naofumi Fukata ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Ph Responsive ◽  
Lipid Derivative

scholarly journals Overcoming Endosomal Barrier by Amphotericin B-Loaded Dual pH-Responsive PDMA-b-PDPA Micelleplexes for siRNA Delivery

ACS Nano ◽  
2011 ◽  
Vol 5 (11) ◽  
pp. 9246-9255 ◽  
Author(s):  
Haijun Yu ◽  
Yonglong Zou ◽  
Yiguang Wang ◽  
Xiaonan Huang ◽  
Gang Huang ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Sirna Delivery ◽  
Ph Responsive

scholarly journals pH-responsive hybrid nanoparticle with enhanced dissociation characteristic for siRNA delivery

2018 ◽  
Vol Volume 13 ◽  
pp. 6885-6902 ◽  
Author(s):  
Menghao Shi ◽  
Xiufeng Zhao ◽  
Jiulong Zhang ◽  
Shuang Pan ◽  
Chunrong Yang ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Ph Responsive ◽  
Hybrid Nanoparticle
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