Coat Protein-Dependent Behavior of Poly(ethylene glycol) Tails in Iron Oxide Core Virus-like Nanoparticles

2015 ◽  
Vol 7 (22) ◽  
pp. 12089-12098 ◽  
Author(s):  
Andrey G. Malyutin ◽  
Hu Cheng ◽  
Olivia R. Sanchez-Felix ◽  
Kenneth Carlson ◽  
Barry D. Stein ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Coat Protein ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Dependent Behavior ◽  
Iron Oxide Core ◽  
Poly Ethylene

Controlled release of fluorouracil (5-FU) from chitosan-co-poly(ethylene glycol)/ poly(glycerol sebacate)-co-poly(ethylene glycol)-coated iron oxide

2017 ◽  
Vol 67 (4) ◽  
pp. 212-220 ◽  
Author(s):  
Shayan Naghizadeh ◽  
Nahid Hassanzadeh Nemati ◽  
Alireza Hassani Najafabadi ◽  
Hassan Niknejad ◽  
Mohammad-Mehdi Khani
Keyword(s):  
Iron Oxide ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Yancong Zhang ◽  
Lianying Zhang ◽  
Xinfeng Song ◽  
Xiangling Gu ◽  
Hanwen Sun ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Resonance ◽  
Ethylene Glycol ◽  
Iron Oxide Nanoparticles ◽  
Methyl Ether ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Novel method for synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) coated with polyethylenimine (PEI) and modified with poly(ethylene glycol) methyl ether (MPEG), MPEG-PEI-SPIONs, was developed. PEI-SPIONs were successfully prepared in aqueous system via photochemistry, and their surface was modified with poly(ethylene glycol) methyl ether (MPEG). The so-obtained MPEG-PEI-SPIONs had a uniform hydrodynamic particle size of 34 nm. The successful coating of MPEG-PEI on the SPIONs was ascertained from FT-IR analysis, and the PEI and MPEG fractions in MPEG-PEI-SPIONs were calculated to account for 31% and 12%, respectively. Magnetic measurement revealed that the saturated magnetization of MPEG-PEI-SPIONs reached 46 emu/g and the nanoparticles showed the characteristic of being superparamagnetic. The stability experiment revealed that the MPEG-PEI modification improved the nanoparticles stability greatly.T2 relaxation measurements showed that MPEG-PEI-SPIONs show similarR2 value to the PEI-SPIONs. TheT2-weighted magnetic resonance imaging (MRI) of MPEG-PEI-SPIONs showed that the magnetic resonance signal was enhanced significantly with increasing nanoparticle concentration in water. These results indicated that the MPEG-PEI-SPIONs had great potential for application in MRI.

Structure and Properties of Iron Oxide Nanoparticles Encapsulated by Phospholipids with Poly(ethylene glycol) Tails

2007 ◽  
Vol 111 (49) ◽  
pp. 18078-18086 ◽  
Author(s):  
Eleonora V. Shtykova ◽  
Xinlei Huang ◽  
Nicholas Remmes ◽  
David Baxter ◽  
Barry Stein ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Ethylene Glycol ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Structure And Properties ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Delayed hepatic uptake of multi-phosphonic acid poly(ethylene glycol) coated iron oxide measured by real-time magnetic resonance imaging

RSC Advances ◽  
2016 ◽  
Vol 6 (68) ◽  
pp. 63788-63800 ◽  
Author(s):  
G. Ramniceanu ◽  
B.-T. Doan ◽  
C. Vezignol ◽  
A. Graillot ◽  
C. Loubat ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Ethylene Glycol ◽  
Hepatic Uptake ◽  
Resonance Imaging ◽  
Poly Ethylene Glycol ◽  
Iron Based ◽  
Magnetic Resonance Imaging Mri ◽  
Poly Ethylene

We report on the synthesis, characterization, stability and pharmacokinetics of novel iron based contrast agents for magnetic resonance imaging (MRI).

Advantages of poly(vinyl phosphonic acid)-based double hydrophilic block copolymers for the stabilization of iron oxide nanoparticles

2016 ◽  
Vol 7 (41) ◽  
pp. 6391-6399 ◽  
Author(s):  
K. H. Markiewicz ◽  
L. Seiler ◽  
I. Misztalewska ◽  
K. Winkler ◽  
S. Harrisson ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Iron Oxide Nanoparticles ◽  
Phosphonic Acid ◽  
Oxide Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Double Hydrophilic Block Copolymers ◽  
Vinylphosphonic Acid ◽  
Poly Ethylene

Poly(ethylene glycol)–poly(vinylphosphonic acid) double hydrophilic block copolymers were synthesized by RAFT/MADIX polymerization and used to prepare stable iron oxide nanoparticles.

A mussel-inspired chitooligosaccharide based multidentate ligand for highly stabilized nanoparticles

2015 ◽  
Vol 3 (18) ◽  
pp. 3730-3737 ◽  
Author(s):  
Chichong Lu ◽  
Min Kyu Park ◽  
Chenxin Lu ◽  
Young Haeng Lee ◽  
Kyu Yun Chai
Keyword(s):  
Iron Oxide ◽  
Ethylene Glycol ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Multidentate Ligand ◽  
Poly Ethylene

A mussel-inspired poly(ethylene glycol)-grafted-chitooligosaccharide based multidentate ligand (ML) is designed for preparing robust biocompatible iron oxide nanoparticles. The successful in vivo MRI application confirmed their suitability for biomedical applications.

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