Advantages of poly(vinyl phosphonic acid)-based double hydrophilic block copolymers for the stabilization of iron oxide nanoparticles

2016 ◽  
Vol 7 (41) ◽  
pp. 6391-6399 ◽  
Author(s):  
K. H. Markiewicz ◽  
L. Seiler ◽  
I. Misztalewska ◽  
K. Winkler ◽  
S. Harrisson ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Iron Oxide Nanoparticles ◽  
Phosphonic Acid ◽  
Oxide Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Double Hydrophilic Block Copolymers ◽  
Vinylphosphonic Acid ◽  
Poly Ethylene

Poly(ethylene glycol)–poly(vinylphosphonic acid) double hydrophilic block copolymers were synthesized by RAFT/MADIX polymerization and used to prepare stable iron oxide nanoparticles.

scholarly journals Synthesis of Superparamagnetic Iron Oxide Nanoparticles Modified with MPEG-PEI via Photochemistry as New MRI Contrast Agent

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Yancong Zhang ◽  
Lianying Zhang ◽  
Xinfeng Song ◽  
Xiangling Gu ◽  
Hanwen Sun ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Resonance ◽  
Ethylene Glycol ◽  
Iron Oxide Nanoparticles ◽  
Methyl Ether ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Novel method for synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) coated with polyethylenimine (PEI) and modified with poly(ethylene glycol) methyl ether (MPEG), MPEG-PEI-SPIONs, was developed. PEI-SPIONs were successfully prepared in aqueous system via photochemistry, and their surface was modified with poly(ethylene glycol) methyl ether (MPEG). The so-obtained MPEG-PEI-SPIONs had a uniform hydrodynamic particle size of 34 nm. The successful coating of MPEG-PEI on the SPIONs was ascertained from FT-IR analysis, and the PEI and MPEG fractions in MPEG-PEI-SPIONs were calculated to account for 31% and 12%, respectively. Magnetic measurement revealed that the saturated magnetization of MPEG-PEI-SPIONs reached 46 emu/g and the nanoparticles showed the characteristic of being superparamagnetic. The stability experiment revealed that the MPEG-PEI modification improved the nanoparticles stability greatly.T2 relaxation measurements showed that MPEG-PEI-SPIONs show similarR2 value to the PEI-SPIONs. TheT2-weighted magnetic resonance imaging (MRI) of MPEG-PEI-SPIONs showed that the magnetic resonance signal was enhanced significantly with increasing nanoparticle concentration in water. These results indicated that the MPEG-PEI-SPIONs had great potential for application in MRI.

Structure and Properties of Iron Oxide Nanoparticles Encapsulated by Phospholipids with Poly(ethylene glycol) Tails

2007 ◽  
Vol 111 (49) ◽  
pp. 18078-18086 ◽  
Author(s):  
Eleonora V. Shtykova ◽  
Xinlei Huang ◽  
Nicholas Remmes ◽  
David Baxter ◽  
Barry Stein ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Ethylene Glycol ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Structure And Properties ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

A mussel-inspired chitooligosaccharide based multidentate ligand for highly stabilized nanoparticles

2015 ◽  
Vol 3 (18) ◽  
pp. 3730-3737 ◽  
Author(s):  
Chichong Lu ◽  
Min Kyu Park ◽  
Chenxin Lu ◽  
Young Haeng Lee ◽  
Kyu Yun Chai
Keyword(s):  
Iron Oxide ◽  
Ethylene Glycol ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Multidentate Ligand ◽  
Poly Ethylene

A mussel-inspired poly(ethylene glycol)-grafted-chitooligosaccharide based multidentate ligand (ML) is designed for preparing robust biocompatible iron oxide nanoparticles. The successful in vivo MRI application confirmed their suitability for biomedical applications.

scholarly journals Preventing Corona Effects: Multiphosphonic Acid Poly(ethylene glycol) Copolymers for Stable Stealth Iron Oxide Nanoparticles

2014 ◽  
Vol 15 (8) ◽  
pp. 3171-3179 ◽  
Author(s):  
V. Torrisi ◽  
A. Graillot ◽  
L. Vitorazi ◽  
Q. Crouzet ◽  
G. Marletta ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Ethylene Glycol ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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