Convenient Fabrication of Electrospun Prolamin Protein Delivery System with Three-Dimensional Shapeability and Resistance to Fouling

2015 ◽  
Vol 7 (24) ◽  
pp. 13422-13430 ◽  
Author(s):  
Yixiang Wang ◽  
Jingqi Yang ◽  
Lingyun Chen
Keyword(s):  
Delivery System ◽  
Protein Delivery ◽  
Three Dimensional

An Update on Recent Advances in Cubosome: A Novel Drug Delivery System

2021 ◽  
Vol 21 ◽  
Author(s):  
Madhukar Garg ◽  
Anju Goyal ◽  
Sapna Kumari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Lipid Bilayers ◽  
Delivery System ◽  
Liquid Crystalline ◽  
Three Dimensional ◽  
Biologically Active ◽  
Potential Applications ◽  
Health Related ◽  
Novel Drug

: Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three dimensional honeycombs like structure provided with two internal aqueous channels for incorporation of number of biologically active ingredients. In contrast liposomes they provide large surface area for incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as method of choice in the sustained release, controlled release and targeted release dosage forms as new drug delivery system for the better release of the drugs. As lot of advancement in the new form of dosage form has bring the novel avenues in drug delivery mechanisms so it was matter of worth to compile the latest updates on the various aspects of mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health related benefits.

scholarly journals The BinaryClostridium botulinumC2 Toxin as a Protein Delivery System

2001 ◽  
Vol 277 (7) ◽  
pp. 5074-5081 ◽  
Author(s):  
Holger Barth ◽  
Robert Roebling ◽  
Michaela Fritz ◽  
Klaus Aktories
Keyword(s):  
Delivery System ◽  
Protein Delivery

Dynamic Modeling of Powder Delivery Systems in Gravity-Fed Powder Feeders

2005 ◽  
Vol 128 (1) ◽  
pp. 337-345 ◽  
Author(s):  
Heng Pan ◽  
Robert G. Landers ◽  
Frank Liou
Keyword(s):  
System Dynamics ◽  
Delivery System ◽  
Mechanical Design ◽  
Three Dimensional ◽  
Low Flow ◽  
Order System ◽  
Tube Length ◽  
Design Parameters ◽  
Simulation Studies ◽  
Transport Delay

This paper presents an approach for modeling powder delivery system dynamics in low flow rate applications. Discrete particle modeling (DPM) is utilized to analyze the motion of individual powder particles. In DPM, an irregular bouncing model is employed to represent the powder dispersion in the powder delivery system induced by non-spherical particle-wall collisions. A three-dimensional friction collision model is utilized to simulate the interactions between particles and the powder delivery system walls. The modeling approach is experimentally verified and simulation studies are conducted to explore the effect of powder delivery system mechanical design parameters (i.e., tube length, diameter, and angle, number of tubes and meshes, and mesh orientation and size) on the powder flow dynamics. The simulation studies demonstrate that the powder delivery system dynamics can be modeled by a pure transport delay coupled with a first order system.

scholarly journals Titania nanotube-based protein delivery system to inhibit cranial bone regeneration in Crouzon model of craniosynostosis

2019 ◽  
Vol Volume 14 ◽  
pp. 6313-6324 ◽  
Author(s):  
Manpreet Bariana ◽  
John A Kaidonis ◽  
Dusan Losic ◽  
Sarbin Ranjitkar ◽  
Peter J Anderson
Keyword(s):  
Bone Regeneration ◽  
Delivery System ◽  
Protein Delivery ◽  
Cranial Bone ◽  
Titania Nanotube

Fabrication of Bio-Composite Drug Delivery System Using Rapid Prototyping Technology

2007 ◽  
Vol 342-343 ◽  
pp. 497-500 ◽  
Author(s):  
Won Shik Chu ◽  
Sung Geun Kim ◽  
Hyung Jung Kim ◽  
Caroline S. Lee ◽  
Sung Hoon Ahn
Keyword(s):  
Drug Delivery ◽  
Composite Materials ◽  
Rapid Prototyping ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Rate ◽  
Three Dimensional ◽  
Deposition Process ◽  
Porous Microstructure

The rapid prototyping (RP) technology has advanced in various fields such as verification of design, and functional test. Recently, researchers have studied bio-materials to fabricate functional bio-RP parts. In this research, a nano composite deposition system (NCDS) was developed to fabricate three-dimensional functional parts for bio-applications. In the hybrid process, the material removal process by mechanical micro machining and/or the deposition process are combined. NCDS uses biocompatible or biodegradable polymer resin as matrix and various bioceramics to form bio-composite materials. To test drug release rate in vivo environment, two different types of drug delivery system (DDS) were fabricated using the bio-composite materials. 1) Container type DDS used poly(DL-lactide-co-glycolide acid)(50:50) and 5-fluorouracil as the drug composite while polycaprolactone(PCL) served as the container of the drug. 2) Scaffold type DDS formed porous microstructure with poly(DL-lactide-co-glycolide acid)(50:50) and 5-fluorouracil composite. The effect of geometry of the DDS on release rate of drug is under investigation.

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