A Three-Dimensional Polycaprolactone Scaffold Combined with a Drug Delivery System Consisting of Electrospun Nanofibers

2011 ◽  
Vol 100 (2) ◽  
pp. 424-430 ◽  
Author(s):  
Hyeon Yoon ◽  
Geunhyung Kim
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Three Dimensional ◽  
Electrospun Nanofibers

An Update on Recent Advances in Cubosome: A Novel Drug Delivery System

2021 ◽  
Vol 21 ◽  
Author(s):  
Madhukar Garg ◽  
Anju Goyal ◽  
Sapna Kumari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Lipid Bilayers ◽  
Delivery System ◽  
Liquid Crystalline ◽  
Three Dimensional ◽  
Biologically Active ◽  
Potential Applications ◽  
Health Related ◽  
Novel Drug

: Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three dimensional honeycombs like structure provided with two internal aqueous channels for incorporation of number of biologically active ingredients. In contrast liposomes they provide large surface area for incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as method of choice in the sustained release, controlled release and targeted release dosage forms as new drug delivery system for the better release of the drugs. As lot of advancement in the new form of dosage form has bring the novel avenues in drug delivery mechanisms so it was matter of worth to compile the latest updates on the various aspects of mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health related benefits.

scholarly journals A Summary of Electrospun Nanofibers as Drug Delivery System: Drugs Loaded and Biopolymers Used as Matrices

2018 ◽  
Vol 15 (10) ◽  
pp. 1360-1374 ◽  
Author(s):  
Erick José Torres-Martinez ◽  
José Manuel Cornejo Bravo ◽  
Aracely Serrano Medina ◽  
Graciela Lizeth Pérez González ◽  
Luis Jesús Villarreal Gómez
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Electrospun Nanofibers

Fabrication of Bio-Composite Drug Delivery System Using Rapid Prototyping Technology

2007 ◽  
Vol 342-343 ◽  
pp. 497-500 ◽  
Author(s):  
Won Shik Chu ◽  
Sung Geun Kim ◽  
Hyung Jung Kim ◽  
Caroline S. Lee ◽  
Sung Hoon Ahn
Keyword(s):  
Drug Delivery ◽  
Composite Materials ◽  
Rapid Prototyping ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Rate ◽  
Three Dimensional ◽  
Deposition Process ◽  
Porous Microstructure

The rapid prototyping (RP) technology has advanced in various fields such as verification of design, and functional test. Recently, researchers have studied bio-materials to fabricate functional bio-RP parts. In this research, a nano composite deposition system (NCDS) was developed to fabricate three-dimensional functional parts for bio-applications. In the hybrid process, the material removal process by mechanical micro machining and/or the deposition process are combined. NCDS uses biocompatible or biodegradable polymer resin as matrix and various bioceramics to form bio-composite materials. To test drug release rate in vivo environment, two different types of drug delivery system (DDS) were fabricated using the bio-composite materials. 1) Container type DDS used poly(DL-lactide-co-glycolide acid)(50:50) and 5-fluorouracil as the drug composite while polycaprolactone(PCL) served as the container of the drug. 2) Scaffold type DDS formed porous microstructure with poly(DL-lactide-co-glycolide acid)(50:50) and 5-fluorouracil composite. The effect of geometry of the DDS on release rate of drug is under investigation.

scholarly journals Tailormade Drug Delivery System: A Novel Trio Concept of 3DP+ Hydrogel+ SLA

2019 ◽  
Vol 9 (4-s) ◽  
pp. 861-866 ◽  
Author(s):  
Lalita Devi ◽  
Punam Gaba ◽  
Hitesh Chopra
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery System ◽  
Delivery System ◽  
Three Dimensional ◽  
Three Dimensional Printing ◽  
System A ◽  
Hydrogel Formation ◽  
Organic Fluids ◽  
Dimensional Printing

Hydrogels possess three-dimensional polymeric network structure and equipped for retaining extensive measure of water or organic fluids. This quality makes them as exceptional candidate for the simulation of extra cellular matrixes. For this the three dimensional printing (3DP) has evolved as the technique for the formation of the digital models. The 3DP is capable for processing the prescriptions and the therapeutic gadgets. One of the technique known as stereolithographic (SLA) printing has shown promising results in formulating the hydrogel based system for fabrication. The SLA acts by cross connecting the saps to shape the polymer matrices. Due to water captured in the gels it is conceivable to create the pre- wetted, medicate hydrogels and gadgets. The 3DP helps in formation of tailor made drug delivery system as per needs of patients. Many of Bioinks has been tried up for the hydrogel formation such as collagen, gelatin, hyaluronan, silk, alginate, and nanocellulose etc. Keywords: 3D Printing, Hydrogel, Steriolithography

scholarly journals A Brief Review on Topical Gels as Drug Delivery System

2021 ◽  
pp. 344-357
Author(s):  
Chinmoy Bhuyan ◽  
Dipankar Saha ◽  
Bipul Rabha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Topical Drug Delivery ◽  
Topical Gel ◽  
Semi Solid ◽  
Gel Formulations ◽  
Topical Gels

The method of applying prescription dosage forms to the skin for direct treatment of a cutaneous disorder is known as a topical drug delivery system. Topical gels are semisolid dosage forms in which a liquid phase is constrained within a three-dimensional polymeric matrix derived from natural or semi-synthetic sources with high physical or chemical cross-linking. Because of their intermediate behavior between solid and liquid materials, topical gels are an excellent candidate for transdermal drug delivery. Clinical evidence indicates that topical gel is a safe and effective treatment choice for the management of skin-related diseases, especially when used for local action to avoid the side effects of other conventional dosage forms. Gels, cream, ointment, and paste are the most commonly used semi-solid formulations for topical drug delivery. Gels are colloids in which the liquid medium has thickened to the extent that it behaves like a solid. Since topical gel formulations are less greasy and can be quickly removed from the skin, they offer better drug delivery. In comparison to cream, ointment, and paste, gel formulations have improved application properties and consistency. This article aims to review the principles and recent developments in topical gels, including classification, methods of preparation, applications, and so on.

Smart releasing electrospun nanofibers—poly: L.lactide fibers as dual drug delivery system for biomedical application

2020 ◽  
Vol 16 (1) ◽  
pp. 015022
Author(s):  
Katharina Wulf ◽  
Daniela Arbeiter ◽  
Claudia Matschegewski ◽  
Michael Teske ◽  
Jennifer Huling ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biomedical Application ◽  
Electrospun Nanofibers ◽  
Dual Drug
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