Near-Infrared-Active Copper Molybdenum Sulfide Nanocubes for Phonon-Mediated Clearance of Alzheimer’s β-Amyloid Aggregates

2021 ◽  
Author(s):  
Jinhyeong Jang ◽  
Chan Beum Park
Keyword(s):  
Near Infrared ◽  
Molybdenum Sulfide ◽  
Amyloid Aggregates ◽  
Β Amyloid

Near-Infrared-Active Copper Bismuth Oxide Electrodes for Targeted Dissociation of Alzheimer’s β-Amyloid Aggregates

2020 ◽  
Vol 12 (21) ◽  
pp. 23667-23676
Author(s):  
Yerin Heo ◽  
Kayoung Kim ◽  
Jinhyun Kim ◽  
Jinhyeong Jang ◽  
Chan Beum Park
Keyword(s):  
Bismuth Oxide ◽  
Near Infrared ◽  
Oxide Electrodes ◽  
Amyloid Aggregates ◽  
Β Amyloid

N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils

2020 ◽  
Vol 56 (53) ◽  
pp. 7269-7272
Author(s):  
Yimin Chen ◽  
Chang Yuan ◽  
Tianxin Xie ◽  
Yuying Li ◽  
Bin Dai ◽  
...  
Keyword(s):  
Near Infrared ◽  
Β Amyloid ◽  
Infrared Probes ◽  
Tau Fibrils

In this study, a series of organo difluoroboron probes with a BF2 benzamide moiety was designed, prepared and evaluated as Aβ and Tau probes.

scholarly journals Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience

2015 ◽  
Vol 44 (7) ◽  
pp. 1807-1819 ◽  
Author(s):  
Matteo Staderini ◽  
María Antonia Martín ◽  
Maria Laura Bolognesi ◽  
J. Carlos Menéndez
Keyword(s):  
Near Infrared ◽  
Amyloid Plaques ◽  
Fluorescent Tracers ◽  
Non Invasive ◽  
Nir Imaging ◽  
New Frontier ◽  
Invasive Method ◽  
Β Amyloid

Near infrared (NIR) imaging is a promising and non-invasive method to visualize amyloid plaquesin vivo.

scholarly journals Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model

2020 ◽  
Vol 6 (31) ◽  
pp. eaba0466 ◽  
Author(s):  
Chun Chen ◽  
Eun Hee Ahn ◽  
Seong Su Kang ◽  
Xia Liu ◽  
Ashfaqul Alam ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gut Dysbiosis ◽  
Enhancer Binding Protein ◽  
Amyloid Aggregates ◽  
Gut Leakage ◽  
Β Amyloid ◽  
5Xfad Mice ◽  
Signaling Activation ◽  
The Brain

The gut-brain axis is bidirectional, and gut microbiota influence brain disorders including Alzheimer’s disease (AD). CCAAT/enhancer binding protein β/asparagine endopeptidase (C/EBPβ/AEP) signaling spatiotemporally mediates AD pathologies in the brain via cleaving both β-amyloid precursor protein and Tau. We show that gut dysbiosis occurs in 5xFAD mice, and is associated with escalation of the C/EBPβ/AEP pathway in the gut with age. Unlike that of aged wild-type mice, the microbiota of aged 3xTg mice accelerate AD pathology in young 3xTg mice, accompanied by active C/EBPβ/AEP signaling in the brain. Antibiotic treatment diminishes this signaling and attenuates amyloidogenic processes in 5xFAD, improving cognitive functions. The prebiotic R13 inhibits this pathway and suppresses amyloid aggregates in the gut. R13-induced Lactobacillus salivarius antagonizes the C/EBPβ/AEP axis, mitigating gut leakage and oxidative stress. Our findings support the hypothesis that C/EBPβ/AEP signaling is activated by gut dysbiosis, implicated in AD pathologies in the gut.

A hemicyanine derivative for near-infrared imaging of β-amyloid plaques in Alzheimer's disease

2019 ◽  
Vol 179 ◽  
pp. 736-743 ◽  
Author(s):  
Hua-Li Yang ◽  
Si-Qiang Fang ◽  
Yan-Wei Tang ◽  
Cheng Wang ◽  
Heng Luo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Amyloid Plaques ◽  
Near Infrared Imaging ◽  
Β Amyloid

Self-assembled lipoprotein based gold nanoparticles for detection and photothermal disaggregation of β-amyloid aggregates

2017 ◽  
Vol 53 (13) ◽  
pp. 2102-2105 ◽  
Author(s):  
P. A. T. Martins ◽  
S. Alsaiari ◽  
K. Julfakyan ◽  
Z. Nie ◽  
N. M. Khashab
Keyword(s):  
Gold Nanoparticles ◽  
Aβ Oligomers ◽  
Amyloid Aggregates ◽  
Β Amyloid ◽  
Self Assembled

Curcumin loaded lipoprotein based NPs with an ApoE3 shell and an AuNP core are synthesized for the detection and light-triggered disaggregation of Aβ oligomers.

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