Solvent-Free Fabrication of Self-Regenerating Antibacterial Surfaces Resisting Biofilm Formation

Author(s):  
Cuicui Su ◽  
Yumin Ye ◽  
Haofeng Qiu ◽  
Yabin Zhu
2013 ◽  
Vol 1498 ◽  
pp. 73-78 ◽  
Author(s):  
N. Gozde Durmus ◽  
Erik N. Taylor ◽  
Kim M. Kummer ◽  
Thomas J. Webster

ABSTRACTBiofilms are a major source of medical device-associated infections, due to their persistent growth and antibiotic resistance. Recent studies have shown that engineering surface nanoroughness has great potential to create antibacterial surfaces. In addition, stimulation of bacterial metabolism increases the efficacy of antibacterial agents to eradicate biofilms. In this study, we combined the antibacterial effects of nanorough topographies with metabolic stimulation (i.e., fructose metabolites) to further decrease bacterial growth on polyvinyl chloride (PVC) surfaces, without using antibiotics. We showed for the first time that the presence of fructose on nanorough PVC surfaces decreased planktonic bacteria growth and biofilm formation after 24 hours. Most importantly, a 60% decrease was observed on nanorough PVC surfaces soaked in a 10 mM fructose solution compared to conventional PVC surfaces. In this manner, this study demonstrated that bacteria growth can be significantly decreased through the combined use of fructose and nanorough surfaces and thus should be further studied for a wide range of antibacterial applications.


2017 ◽  
Vol 53 (48) ◽  
pp. 6488-6491 ◽  
Author(s):  
Kitty K. K. Ho ◽  
Berkay Ozcelik ◽  
Mark D. P. Willcox ◽  
Helmut Thissen ◽  
Naresh Kumar

A simple solvent-free method to generate nitric oxide (NO)-releasing coatings for prevention of adhesion and biofilm formation of common pathogens.


2018 ◽  
Vol 6 (26) ◽  
pp. 4274-4292 ◽  
Author(s):  
Xi Li ◽  
Biao Wu ◽  
Hao Chen ◽  
Kaihui Nan ◽  
Yingying Jin ◽  
...  

Since their development over 70 years, antibiotics are still the most effective strategy to treat bacterial biofilms and infections.


Author(s):  
B.D. Tall ◽  
K.S. George ◽  
R. T. Gray ◽  
H.N. Williams

Studies of bacterial behavior in many environments have shown that most organisms attach to surfaces, forming communities of microcolonies called biofilms. In contaminated medical devices, biofilms may serve both as reservoirs and as inocula for the initiation of infections. Recently, there has been much concern about the potential of dental units to transmit infections. Because the mechanisms of biofilm formation are ill-defined, we investigated the behavior and formation of a biofilm associated with tubing leading to the water syringe of a dental unit over a period of 1 month.


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