In Vivo Bioimaging and Photodynamic Therapy Based on Two-Photon Fluorescent Conjugated Polymers Containing Dibenzothiophene-S,S-dioxide Derivatives

2020 ◽  
Vol 12 (51) ◽  
pp. 57281-57289
Author(s):  
Liwen Hu ◽  
Zikang Chen ◽  
Yanshan Liu ◽  
Bishan Tian ◽  
Ting Guo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Two Photon

Water-Soluble Conjugated Polymers for Simultaneous Two-Photon Cell Imaging and Two-Photon Photodynamic Therapy

2013 ◽  
Vol 1 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Xiaoqin Shen ◽  
Lin Li ◽  
Agnes Chow Min Chan ◽  
Nengyue Gao ◽  
Shao Q. Yao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Cell Imaging ◽  
Water Soluble ◽  
Two Photon

A zwitterionic red-emitting water-soluble conjugated polymer with high resistance to nonspecific binding for two-photon cell imaging and good singlet oxygen production capability

2021 ◽  
Author(s):  
Yan-Qin Huang ◽  
Shan-Shan Jiang ◽  
Li-Xiang Pan ◽  
Rui Zhang ◽  
Kun-Lin Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Singlet Oxygen ◽  
High Resistance ◽  
Conjugated Polymer ◽  
Cell Imaging ◽  
Water Soluble ◽  
Oxygen Production ◽  
Nonspecific Binding ◽  
Two Photon

Water-soluble conjugated polymers (WSCPs) with dual capability of two-photon imaging and singlet oxygen (1O2) production have become one type of the most promising agents in noninvasive imaging guided photodynamic therapy...

scholarly journals Can nanotechnology potentiate photodynamic therapy?

2012 ◽  
Vol 1 (2) ◽  
pp. 111-146 ◽  
Author(s):  
Ying-Ying Huang ◽  
Sulbha K. Sharma ◽  
Tianhong Dai ◽  
Hoon Chung ◽  
Anastasia Yaroslavsky ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Plasmonic Enhancement ◽  
Gold And Silver Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Two Photon ◽  
Photon Excitation ◽  
Poorly Soluble ◽  
Delivery Vehicles

AbstractPhotodynamic therapy (PDT) uses the combination of nontoxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided many examples of nanoscale drug-delivery platforms that have been applied to PDT. These include liposomes, lipoplexes, nanoemulsions, micelles, polymer nanoparticles (degradable and nondegradable), and silica nanoparticles. In some cases (fullerenes and quantum dots), the actual nanoparticle itself is the PS. Targeting ligands such as antibodies and peptides can be used to increase specificity. Gold and silver nanoparticles can provide plasmonic enhancement of PDT. Two-photon excitation or optical upconversion can be used instead of one-photon excitation to increase tissue penetration at longer wavelengths. Finally, after sections on in vivo studies and nanotoxicology, we attempt to answer the title question, “can nanotechnology potentiate PDT?”

Super-efficient in Vivo Two-Photon Photodynamic Therapy with a Gold Nanocluster as a Type I Photosensitizer

ACS Nano ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. 9532-9544 ◽  
Author(s):  
Rongcheng Han ◽  
Miao Zhao ◽  
Zhiwei Wang ◽  
Helin Liu ◽  
Shengcang Zhu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Type I ◽  
Gold Nanocluster ◽  
Two Photon

scholarly journals Multifunctional AIE iridium (III) photosensitizer nanoparticles for two-photon-activated imaging and mitochondria targeting photodynamic therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xuzi Cai ◽  
Kang-Nan Wang ◽  
Wen Ma ◽  
Yuanyuan Yang ◽  
Gui Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Solubility ◽  
Tissue Imaging ◽  
Ros Generation ◽  
Generation Efficiency ◽  
Deep Tissue ◽  
Two Photon ◽  
Mitochondria Targeting

AbstractDeveloping novel photosensitizers for deep tissue imaging and efficient photodynamic therapy (PDT) remains a challenge because of the poor water solubility, low reactive oxygen species (ROS) generation efficiency, serve dark cytotoxicity, and weak absorption in the NIR region of conventional photosensitizers. Herein, cyclometalated iridium (III) complexes (Ir) with aggregation-induced emission (AIE) feature, high photoinduced ROS generation efficiency, two-photon excitation, and mitochondria-targeting capability were designed and further encapsulated into biocompatible nanoparticles (NPs). The Ir-NPs can be used to disturb redox homeostasis in vitro, result in mitochondrial dysfunction and cell apoptosis. Importantly, in vivo experiments demonstrated that the Ir-NPs presented obviously tumor-targeting ability, excellent antitumor effect, and low systematic dark-toxicity. Moreover, the Ir-NPs could serve as a two-photon imaging agent for deep tissue bioimaging with a penetration depth of up to 300 μm. This work presents a promising strategy for designing a clinical application of multifunctional Ir-NPs toward bioimaging and PDT.

scholarly journals Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4176
Author(s):  
Hui Shan Liew ◽  
Chun-Wai Mai ◽  
Mohd Zulkefeli ◽  
Thiagarajan Madheswaran ◽  
Lik Voon Kiew ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Two Photon ◽  
Alternative Approach ◽  
Recent Emergence ◽  
Combination Study ◽  
Basic Features ◽  
New Generation

Photodynamic therapy (PDT) is emerging as a significant complementary or alternative approach for cancer treatment. PDT drugs act as photosensitisers, which upon using appropriate wavelength light and in the presence of molecular oxygen, can lead to cell death. Herein, we reviewed the general characteristics of the different generation of photosensitisers. We also outlined the emergence of rhenium (Re) and more specifically, Re(I) tricarbonyl complexes as a new generation of metal-based photosensitisers for photodynamic therapy that are of great interest in multidisciplinary research. The photophysical properties and structures of Re(I) complexes discussed in this review are summarised to determine basic features and similarities among the structures that are important for their phototoxic activity and future investigations. We further examined the in vitro and in vivo efficacies of the Re(I) complexes that have been synthesised for anticancer purposes. We also discussed Re(I) complexes in conjunction with the advancement of two-photon PDT, drug combination study, nanomedicine, and photothermal therapy to overcome the limitation of such complexes, which generally absorb short wavelengths.

scholarly journals NIR Photosensitizer for Two-Photon Fluorescent Imaging and Photodynamic Therapy of Tumor

2021 ◽  
Vol 9 ◽  
Author(s):  
Lujia Chen ◽  
Meijuan Chen ◽  
Yuping Zhou ◽  
Changsheng Ye ◽  
Ruiyuan Liu
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
Deep Tissue ◽  
Two Photon ◽  
Nir Emission ◽  
Good Biocompatibility ◽  
Fluorescent Agent

Preparation of near-infrared (NIR) emissive fluorophore for imaging-guided PDT (photodynamic therapy) has attracted enormous attention. Hence, NIR photosensitizers of two-photon (TP) fluorescent imaging and photodynamic therapy are highly desirable. In this contribution, a novel D-π-A structured NIR photosensitizer (TTRE) is synthesized. TTRE demonstrates near-infrared (NIR) emission, good biocompatibility, and superior photostability, which can act as TP fluorescent agent for clear visualization of cells and vascular in tissue with deep-tissue penetration. The PDT efficacy of TTRE as photosensitizer is exploited in vitro and in vivo. All these results confirm that TTRE would serve as potential platform for TP fluorescence imaging and imaging-guided photodynamic therapy.

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