Selection of Affinity Reagents to Neutralize the Hemolytic Toxicity of Melittin Based on a Self-Assembled Nanoparticle Library

2020 ◽  
Vol 12 (14) ◽  
pp. 16040-16049
Author(s):  
Yaqing Xu ◽  
Meitao Deng ◽  
Haitao Zhang ◽  
Sha Tan ◽  
Dan Li ◽  
...  
Keyword(s):  
Affinity Reagents ◽  
Self Assembled ◽  
Hemolytic Toxicity ◽  
Selection Of

Impurity doping in self-assembled InAs/GaAs quantum dots by selection of growth steps

2010 ◽  
Vol 108 (6) ◽  
pp. 063524 ◽  
Author(s):  
Tomoya Inoue ◽  
Satoshi Kido ◽  
Kengo Sasayama ◽  
Takashi Kita ◽  
Osamu Wada
Keyword(s):  
Quantum Dots ◽  
Impurity Doping ◽  
Self Assembled ◽  
Selection Of

scholarly journals A myopic perspective on the future of protein diagnostics

2017 ◽  
Author(s):  
Ulf Landegren ◽  
Rasel A. Al-Amin ◽  
Johan Björkesten
Keyword(s):  
The Body ◽  
Optimal Selection ◽  
Plasma Proteome ◽  
Protein Biomarkers ◽  
Affinity Reagents ◽  
Target Proteins ◽  
Ongoing Work ◽  
The Future ◽  
Protein Diagnostics ◽  
Selection Of

Plasma proteome analyses of the future promise invaluable insights into states of health, not only by measuring proteins whose role it is to ensure blood homeostasis, but increasingly also as a window into the health of practically any tissue in the body via so-called leakage protein biomarkers. Realizing more of this vast potential will require progress along many lines. Here we discuss the main ones, such as optimal selection of target proteins, affinity reagents, immunoassay formats, samples, and applications, with a view from ongoing work in our laboratory.

scholarly journals Shape, Size and Morphology Control of Inorganic Crystals With Self-Assembled Monolayers

2004 ◽  
Vol 823 ◽  
Author(s):  
Yong-Jin Han ◽  
Joanna Aizenberg
Keyword(s):  
Organic Molecules ◽  
Nucleation And Growth ◽  
Self Assembled Monolayers ◽  
Careful Selection ◽  
Inorganic Crystals ◽  
Assembled Monolayers ◽  
Self Assembled ◽  
Size And Morphology ◽  
Size And Morphology Control ◽  
Selection Of

AbstractSelf-assembled monolayers (SAMs) provide simple, yet sophisticated surfaces to mimic the effect of proteins associated with the process of biomineralization. A careful selection of organic molecules with an appropriate surface chemistry (i.e. HS-(CH2)n-X− supported on a metal surface) allows the nucleation and growth of oriented calcite crystals and provides opportunities to study the formation of inorganic crystals assisted by organic molecules. We have successfully crystallized calcite crystals on different SAMs in the presence of additives such as proteins and/or ions in solution, and found correlations between the orientations of crystals to their final shapes, sizes and morphologies. We report here our experimental results demonstrating how underlying organic molecules along with inorganic additives can control and mold the final shape, size and morphology of calcium carbonate crystals

Microfluidics in the selection of affinity reagents for the detection of cancer: paving a way towards future diagnostics

Lab on a Chip ◽  
2016 ◽  
Vol 16 (15) ◽  
pp. 2759-2774 ◽  
Author(s):  
Lien-Yu Hung ◽  
Chih-Hung Wang ◽  
Chien-Yu Fu ◽  
Priya Gopinathan ◽  
Gwo-Bin Lee
Keyword(s):  
Cancer Cells ◽  
Cancer Biomarkers ◽  
Cancer Diagnostics ◽  
Review Article ◽  
Microfluidic Platforms ◽  
Affinity Reagents ◽  
Selection Of

In this review article, the selection of affinity reagents for cancer cells or cancer biomarkers on microfluidic platforms is reviewed with the aim of highlighting the utility of such approaches in cancer diagnostics.

Selection of conformational states in self-assembled surface structures formed from an oligo(naphthylene–ethynylene) 3-bit binary switch

2015 ◽  
Vol 142 (10) ◽  
pp. 101922 ◽  
Author(s):  
Y. Ning ◽  
J. R. Cramer ◽  
A. Nuermaimaiti ◽  
K. Svane ◽  
M. Yu ◽  
...  
Keyword(s):  
Surface Structures ◽  
Conformational States ◽  
Binary Switch ◽  
Self Assembled ◽  
Selection Of

scholarly journals Self‐Assembled Artificial Ion‐Channels toward Natural Selection of Functions

2020 ◽  
Vol 60 (2) ◽  
pp. 566-597 ◽  
Author(s):  
Shao‐Ping Zheng ◽  
Li‐Bo Huang ◽  
Zhanhu Sun ◽  
Mihail Barboiu
Keyword(s):  
Natural Selection ◽  
Ion Channels ◽  
Self Assembled ◽  
Selection Of

scholarly journals Self-assembled ruthenium (II) metallacycles and metallacages with imidazole-based ligands and their in vitro anticancer activity

2019 ◽  
Vol 116 (10) ◽  
pp. 4090-4098 ◽  
Author(s):  
Yibo Zhao ◽  
Liqian Zhang ◽  
Xu Li ◽  
Yanhui Shi ◽  
Ruru Ding ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Self Assembly ◽  
Binding Modes ◽  
Hct 116 ◽  
Self Assembled ◽  
Half Sandwich ◽  
Trigonal Prismatic ◽  
Selection Of ◽  
Mcf 7

Six tetranuclear rectangular metallacycles were synthesized via the [2+2] coordination-driven self-assembly of imidazole-based ditopic donor 1,4-bis(imidazole-1-yl)benzene and 1,3-bis(imidazol-1-yl)benzene, with dinuclear half-sandwichp-cymene ruthenium(II) acceptors [Ru2(µ-η4-oxalato)(η6-p-cymene)2](SO3CF3)2, [Ru2(µ-η4-2,5-dioxido-1,4-benzoquinonato)(η6-p-cymene)2](SO3CF3)2and [Ru2(µ-η4-5,8-dioxido-1,4-naphtoquinonato)(η6-p-cymene)2](SO3CF3)2, respectively. Likewise, three hexanuclear trigonal prismatic metallacages were prepared via the [2+3] self-assembly of tritopic donor of 1,3,5-tri(1H-imidazol-1-yl)benzene with these ruthenium(II) acceptors respectively. Self-selection of the single symmetrical and stable metallacycle and cage was observed although there is the possibility of forming different conformational isomeric products due to different binding modes of these imidazole-based donors. The self-assembled macrocycles and cage containing the 5,8-dioxido-1,4-naphtoquinonato (donq) spacer exhibited good anticancer activity on all tested cancer cell lines (HCT-116, MDA-MB-231, MCF-7, HeLa, A549, and HepG-2), and showed decreased cytotoxicities in HBE and THLE-2 normal cells. The effect of Ru and imidazole moiety of these assemblies on the anticancer activity was discussed. The study of binding ability of these donq-based Ru assemblies with ctDNA indicated that the complex 9 with 180° linear 1 ligand has the highest bonding constantKbto ctDNA.

scholarly journals Self-assembled materials and supramolecular chemistry within microfluidic environments: from common thermodynamic states to non-equilibrium structures

2018 ◽  
Vol 47 (11) ◽  
pp. 3788-3803 ◽  
Author(s):  
S. Sevim ◽  
A. Sorrenti ◽  
C. Franco ◽  
S. Furukawa ◽  
S. Pané ◽  
...  
Keyword(s):  
Supramolecular Chemistry ◽  
Self Assembly ◽  
Equilibrium Structures ◽  
Self Assembled ◽  
Selection Of ◽  
Non Equilibrium

Microfluidics enables selection of different pathways in self-assembly processes, while allowing for an exquisite control over the processing of self-assembled materials.

Conformation-selective coordination-driven self-assembly of a ditopic donor with PdII acceptors

2015 ◽  
Vol 44 (47) ◽  
pp. 20493-20501 ◽  
Author(s):  
Prodip Howlader ◽  
Sandip Mukherjee ◽  
Rajat Saha ◽  
Partha Sarathi Mukherjee
Keyword(s):  
Self Assembly ◽  
Theoretical Study ◽  
Self Assembled ◽  
Specific Metal ◽  
Selection Of

Different binding conformations of 3-(5-(pyridin-3-yl)-1H-1,2,4-triazol-3-yl)pyridine (L) yielded a self-assembled 3D cube and 2D macrocycles selectively depending on the nature of acceptors. Selection of a particular conformation of the donor L by a specific metal acceptor during self-assembly was corroborated well by a theoretical study.

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