In Situ Ratiometric Fluorescence Imaging for Tracking Targeted Delivery and Release of Anticancer Drug in Living Tumor Cells

2019 ◽  
Vol 2 (11) ◽  
pp. 4687-4692 ◽  
Author(s):  
Keqin Yang ◽  
Jingjin Zhao ◽  
Liangliang Zhang ◽  
Rongjun Liu ◽  
Hong Liang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Fluorescence Imaging ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Ratiometric Fluorescence

scholarly journals Ratiometric fluorescence imaging of Golgi H2O2 reveals a correlation between Golgi oxidative stress and hypertension

2019 ◽  
Vol 10 (47) ◽  
pp. 10876-10880 ◽  
Author(s):  
Hui Wang ◽  
Zixu He ◽  
Yuyun Yang ◽  
Jiao Zhang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fluorescent Probe ◽  
Fluorescence Imaging ◽  
Living Systems ◽  
Ratiometric Fluorescence ◽  
Two Photon ◽  
Group A ◽  
Ratiometric Imaging

Based on a novel Golgi-targeting phenylsulfonamide group, a two-photon (TP) fluorescent probe, Np-Golgi, was developed for in situ H2O2 ratiometric imaging in living systems.

scholarly journals Double-ratiometric fluorescence imaging of H2Se and O2˙− under hypoxia for exploring Na2SeO3-induced HepG2 cells' apoptosis

RSC Advances ◽  
2018 ◽  
Vol 8 (71) ◽  
pp. 40984-40988 ◽  
Author(s):  
Xiaonan Gao ◽  
Wenfei Guo ◽  
Lihong Ge ◽  
Fanpeng Kong ◽  
Kehua Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tumor Cells ◽  
Fluorescence Imaging ◽  
Hepg2 Cells ◽  
Sodium Selenite ◽  
Stress Process ◽  
Ratiometric Fluorescence ◽  
Induced Apoptosis

Sodium selenite (Na2SeO3), as an anti-tumor drug for inducing tumor cells' apoptosis, has been widely studied under normoxic conditions and has been shown to exhibit oxidative stress process-induced apoptosis.

Actively targeted delivery of anticancer drug to tumor cells by redox-responsive star-shaped micelles

Biomaterials ◽  
2014 ◽  
Vol 35 (30) ◽  
pp. 8711-8722 ◽  
Author(s):  
Chunli Shi ◽  
Xing Guo ◽  
Qianqian Qu ◽  
Zhaomin Tang ◽  
Yi Wang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Redox Responsive

Nano Technological Approach for Anti-Tumor Therapy: Opportunities and Challenges

2020 ◽  
Vol 10 ◽  
Author(s):  
Krishna Champaneria ◽  
Prajesh Prajapati
Keyword(s):  
Adverse Effects ◽  
Tumor Cells ◽  
Targeted Delivery ◽  
Blood Circulation ◽  
Review Paper ◽  
Tumor Therapy ◽  
Conventional Chemotherapy ◽  
Targeting Delivery ◽  
Tumor Accumulation ◽  
Work Done

Cancer is one of the reason for mortality and its individual and collective impact is substantial. Conventional chemotherapy utilizes drugs that can destroy Tumor cells effectively. But these agents destroy healthy cells along with the tumor cells, leading to many adverse effects which include hypersensitivity reactions, nephrotoxicity, and neurotoxicity. To minimize the adverse effects, various drug delivery systems (DDSs) has been developed. Among them, nanoparticles are attractive platforms for it. So this review paper explores the recent work done on targeted delivery, enhancing tumor accumulation and longer blood circulation using more effective biomaterial that will enhance the properties of nanoparticles. Moreover, various target-specific delivery of drugs like antibody-targeted, targeting delivery through angiogenesis, mitochondria, CD44 receptor are also explained.

scholarly journals Bone tumor-targeted delivery of theranostic 195mPt-bisphosphonate complexes promotes killing of metastatic tumor cells

2020 ◽  
pp. 100088
Author(s):  
Robin A. Nadar ◽  
Gerben M. Franssen ◽  
Natasja W.M. Van Dijk ◽  
Karlijn Codee-van der Schilden ◽  
Mirjam de Weijert ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Bone Tumor ◽  
Targeted Delivery ◽  
Metastatic Tumor
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