Combining Coaxial Electrospinning and 3D Printing: Design of Biodegradable Bilayered Membranes with Dual Drug Delivery Capability for Periodontitis Treatment

2021 ◽  
Author(s):  
Danilo M. dos Santos ◽  
Sarah R. de Annunzio ◽  
Juliana C. Carmello ◽  
Ana C. Pavarina ◽  
Carla R. Fontana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Coaxial Electrospinning ◽  
Dual Drug

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

3D Printing & Pharmaceutical Manufacturing: Opportunities and Challenges

2016 ◽  
Vol 5 (01) ◽  
pp. 4723 ◽  
Author(s):  
Bhusnure O. G.* ◽  
Gholve V. S. ◽  
Sugave B. K. ◽  
Dongre R. C. ◽  
Gore S. A. ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
3D Printing ◽  
Computer Aided Design ◽  
Patient Specific ◽  
Computer Design ◽  
3D Scaffolds ◽  
Engineering Research ◽  
Advantages And Disadvantages ◽  
Computer Aided

Many researchers have attempted to use computer-aided design (C.A.D) and computer-aided manufacturing (CAM) to realize a scaffold that provides a three-dimensional (3D) environment for regeneration of tissues and organs. As a result, several 3D printing technologies, including stereolithography, deposition modeling, inkjet-based printing and selective laser sintering have been developed. Because these 3D printing technologies use computers for design and fabrication, and they can fabricate 3D scaffolds as designed; as a consequence, they can be standardized. Growth of target tissues and organs requires the presence of appropriate growth factors, so fabrication of 3Dscaffold systems that release these biomolecules has been explored. A drug delivery system (D.D.S) that administrates a pharmaceutical compound to achieve a therapeutic effect in cells, animals and humans is a key technology that delivers biomolecules without side effects caused by excessive doses. 3D printing technologies and D. D. Ss have been assembled successfully, so new possibilities for improved tissue regeneration have been suggested. If the interaction between cells and scaffold system with biomolecules can be understood and controlled, and if an optimal 3D tissue regenerating environment is realized, 3D printing technologies will become an important aspect of tissue engineering research in the near future. 3D Printing promises to produce complex biomedical devices according to computer design using patient-specific anatomical data. Since its initial use as pre-surgical visualization models and tooling molds, 3D Printing has slowly evolved to create one-of-a-kind devices, implants, scaffolds for tissue engineering, diagnostic platforms, and drug delivery systems. Fuelled by the recent explosion in public interest and access to affordable printers, there is renewed interest to combine stem cells with custom 3D scaffolds for personalized regenerative medicine. Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. Until recently, tablet designs had been restricted to the relatively small number of shapes that are easily achievable using traditional manufacturing methods. As 3D printing capabilities develop further, safety and regulatory concerns are addressed and the cost of the technology falls, contract manufacturers and pharmaceutical companies that experiment with these 3D printing innovations are likely to gain a competitive edge. This review compose the basics, types & techniques used, advantages and disadvantages of 3D printing

Emerging 3D printing technologies for drug delivery devices: Current status and future perspective

2021 ◽  
Author(s):  
Jiawei Wang ◽  
Yu Zhang ◽  
Niloofar Heshmati Aghda ◽  
Amit Raviraj Pillai ◽  
Rishi Thakkar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Current Status ◽  
Future Perspective ◽  
Drug Delivery Devices

Dual drug delivery of vancomycin and imipenem/cilastatin by coaxial nanofibers for treatment of diabetic foot ulcer infections

2021 ◽  
Vol 123 ◽  
pp. 111975
Author(s):  
Farideh Davani ◽  
Mohsen Alishahi ◽  
Mohammad Sabzi ◽  
Mohammad Khorram ◽  
Amir Arastehfar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Dual Drug

scholarly journals Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy

2021 ◽  
Vol 6 (8) ◽  
pp. 2372-2389
Author(s):  
Song Xue ◽  
Xiaojun Zhou ◽  
Weilin Sang ◽  
Cong Wang ◽  
Haiming Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeting Peptide ◽  
Nir Laser ◽  
Dual Drug

Star-Shaped Polylactide Dipyridamole Conjugated to 5-Fluorouracil and 4-Piperidinopiperidine Nanocarriers for Bioimaging and Dual Drug Delivery in Cancer Cells

2021 ◽  
Author(s):  
Dhanya Moorkoth ◽  
Kesavan Madhavan Nampoothiri ◽  
Selvaraj Nagarajan ◽  
Aswathy Ravindran Girija ◽  
Sivakumar Balasubramaniyan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Dual Drug

Photosensitizer-Incorporated Quadruplex DNA-Gated Nanovechicles for Light-Triggered, Targeted Dual Drug Delivery to Cancer Cells

Small ◽  
2013 ◽  
Vol 9 (16) ◽  
pp. 2793-2800 ◽  
Author(s):  
Cuie Chen ◽  
Li Zhou ◽  
Jie Geng ◽  
Jinsong Ren ◽  
Xiaogang Qu
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Quadruplex Dna ◽  
Dual Drug

Surface-engineered dendrimers for dual drug delivery: A receptor up-regulation and enhanced cancer targeting strategy

2008 ◽  
Vol 16 (10) ◽  
pp. 758-772 ◽  
Author(s):  
Rakesh Kumar Tekade ◽  
Tathagata Dutta ◽  
Abhishek Tyagi ◽  
Alok Chandra Bharti ◽  
Bhudev Chandra Das ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Targeting ◽  
Targeting Strategy ◽  
Dual Drug
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