scholarly journals Efficient DNA Condensation Induced by Chiral β-Amino Acid-Based Cationic Surfactants

2021 ◽  
Author(s):  
Bernat Pi-Boleda ◽  
Sravani Ramisetty ◽  
Ona Illa ◽  
Vicenç Branchadell ◽  
Rita S. Dias ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cationic Surfactants ◽  
Dna Condensation

scholarly journals Biological and Physico-Chemical Characteristics of Arginine-Rich Peptide Gemini Surfactants with Lysine and Cystine Spacers

2021 ◽  
Vol 22 (7) ◽  
pp. 3299
Author(s):  
Damian Neubauer ◽  
Maciej Jaśkiewicz ◽  
Marta Bauer ◽  
Agata Olejniczak-Kęder ◽  
Emilia Sikorska ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Cationic Surfactants ◽  
Antimicrobial Agents ◽  
Gemini Surfactants ◽  
Antimicrobial Activities ◽  
Critical Aggregation Concentration ◽  
Cytotoxic Activities ◽  
Candida Sp ◽  
Enhanced Selectivity

Ultrashort cationic lipopeptides (USCLs) and gemini cationic surfactants are classes of potent antimicrobials. Our recent study has shown that the branching and shortening of the fatty acids chains with the simultaneous addition of a hydrophobic N-terminal amino acid in USCLs result in compounds with enhanced selectivity. Here, this approach was introduced into arginine-rich gemini cationic surfactants. L-cystine diamide and L-lysine amide linkers were used as spacers. Antimicrobial activity against planktonic and biofilm cultures of ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) strains and Candida sp. as well as hemolytic and cytotoxic activities were examined. Moreover, antimicrobial activity in the presence of human serum and the ability to form micelles were evaluated. Membrane permeabilization study, serum stability assay, and molecular dynamics were performed. Generally, critical aggregation concentration was linearly correlated with hydrophobicity. Gemini surfactants were more active than the parent USCLs, and they turned out to be selective antimicrobial agents with relatively low hemolytic and cytotoxic activities. Geminis with the L-cystine diamide spacer seem to be less cytotoxic than their L-lysine amide counterparts, but they exhibited lower antibiofilm and antimicrobial activities in serum. In some cases, geminis with branched fatty acid chains and N-terminal hydrophobic amino acid resides exhibited enhanced selectivity to pathogens over human cells.

Amino Acid Based Cationic Surfactants in Aqueous Solution:  Physicochemical Study and Application of Supramolecular Chirality in Ketone Reduction

Langmuir ◽  
2005 ◽  
Vol 21 (23) ◽  
pp. 10398-10404 ◽  
Author(s):  
Sangita Roy ◽  
Debapratim Das ◽  
Antara Dasgupta ◽  
Rajendra Narayan Mitra ◽  
Prasanta Kumar Das
Keyword(s):  
Aqueous Solution ◽  
Amino Acid ◽  
Cationic Surfactants ◽  
Physicochemical Study ◽  
Ketone Reduction ◽  
Supramolecular Chirality

scholarly journals Effect of the Head-Group Geometry of Amino Acid-Based Cationic Surfactants on Interaction with Plasmid DNA

2008 ◽  
Vol 9 (7) ◽  
pp. 1852-1859 ◽  
Author(s):  
Vaibhav Jadhav ◽  
Souvik Maiti ◽  
Antara Dasgupta ◽  
Prasanta Kumar Das ◽  
Rita S. Dias ◽  
...  
Keyword(s):  
Amino Acid ◽  
Plasmid Dna ◽  
Cationic Surfactants ◽  
Head Group

scholarly journals The Stereoselective Deacylation of Long-chain Amino Acid Esters by Comicelles ofN-Acyl-L-histidine and Various Cationic Surfactants

1981 ◽  
Vol 54 (2) ◽  
pp. 576-580 ◽  
Author(s):  
Katsutoshi Ohkubo ◽  
Kiyoshi Sugahara ◽  
Hidefumi Ohta ◽  
Katsuro Tokuda ◽  
Ryuichi Ueoka
Keyword(s):  
Amino Acid ◽  
Cationic Surfactants ◽  
Amino Acid Esters ◽  
Acid Esters ◽  
Long Chain

High stereoselectivity in the deacylation of amino acid esters by comicelles of di- or tri-peptide nucleophiles and chiral cationic surfactants

1984 ◽  
Vol 23 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Katsutoshi Ohkubo ◽  
Masaru Nagasaki ◽  
Kazuhiro Yamaki ◽  
Harumi Ogata ◽  
Kohichi Yamashita
Keyword(s):  
Amino Acid ◽  
Cationic Surfactants ◽  
Amino Acid Esters ◽  
High Stereoselectivity ◽  
Acid Esters

Self-Organized Meso- and Hybridic Phases of Poly(aspartic acid) and Poly(glutamic amino acid) with Cationic Surfactants (CnTAB,n= 14, 16) and a Silica Source (TEOS)

2007 ◽  
Vol 19 (7) ◽  
pp. 1853-1861 ◽  
Author(s):  
Eleftheria K. Kodona ◽  
Charalambos Alexopoulos ◽  
Eugenia Panou ◽  
Philippos J. Pomonis
Keyword(s):  
Amino Acid ◽  
Aspartic Acid ◽  
Cationic Surfactants ◽  
Self Organized ◽  
Silica Source
Sign in / Sign up

Export Citation Format

Share Document