Gallium Complex-Functionalized P4HB Fibers: A Trojan Horse to Fight Bacterial Infection

2020 ◽  
Author(s):  
Adrienne Müller ◽  
Claudia Fessele ◽  
Flavia Zuber ◽  
Markus Rottmar ◽  
Katharina Maniura-Weber ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Trojan Horse ◽  
Gallium Complex

scholarly journals Persistence of Brucella abortus in the Bone Marrow of Infected Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Cristina Gutiérrez-Jiménez ◽  
Lisiena Hysenaj ◽  
Alejandro Alfaro-Alarcón ◽  
Ricardo Mora-Cartín ◽  
Vilma Arce-Gorvel ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Bacterial Infection ◽  
Acute Phase ◽  
Brucella Abortus ◽  
Mononuclear Phagocyte ◽  
Trojan Horse ◽  
Mononuclear Phagocyte System ◽  
Histopathological Changes ◽  
Chronic Infections

Brucellosis is a zoonotic bacterial infection that may persist for long periods causing relapses in antibiotic-treated patients. The ability of Brucella to develop chronic infections is linked to their capacity to invade and replicate within the mononuclear phagocyte system, including the bone marrow (BM). Persistence of Brucella in the BM has been associated with hematological complications such as neutropenia, thrombocytopenia, anemia, and pancytopenia in human patients. In the mouse model, we observed that the number of Brucella abortus in the BM remained constant for up to 168 days of postinfection. This persistence was associated with histopathological changes, accompanied by augmented numbers of BM myeloid GMP progenitors, PMNs, and CD4+ lymphocytes during the acute phase (eight days) of the infection in the BM. Monocytes, PMNs, and GMP cells were identified as the cells harboring Brucella in the BM. We propose that the BM is an essential niche for the bacterium to establish long-lasting infections and that infected PMNs may serve as vehicles for dispersion of Brucella organisms, following the Trojan horse hypothesis. Monocytes are solid candidates for Brucella reservoirs in the BM.

Beware of ‘Trojan Horse Marketing’

2008 ◽  
Vol 39 (12) ◽  
pp. 14
Author(s):  
CHARLESE. CRUTCHFIELD
Keyword(s):  
Trojan Horse

Herpetic Whitlow of the Hand in Infants

2020 ◽  
Author(s):  
Mohammad M. Al-Qattan ◽  
Nada G. AlQadri ◽  
Ghada AlHayaza
Keyword(s):  
Bacterial Infection ◽  
Case Reports ◽  
Case Series ◽  
Individual Case ◽  
Senior Author ◽  
Secondary Bacterial Infection ◽  
Clinical Appearance ◽  
History Of ◽  
Mode Of Transmission ◽  
Time Of Presentation

Abstract Introduction Herpetic whitlows in infants are rare. Previous authors only reported individual case reports. We present a case series of six infants. Materials and Methods This is a retrospective study of six cases of herpetic whitlows in infants seen by the senior author (MMA) over the past 23 years (1995–2017 inclusive). The following data were collected: age, sex, digit involved in the hand, mode of transmission, time of presentation to the author, clinical appearance, presence of secondary bacterial infection, presence of other lesions outside the hand, method of diagnosis, treatment, and outcome. Results All six infants initially presented with classic multiple vesicles of the digital pulp. In all cases, there was a history of active herpes labialis in the mother. Incision and drainage or deroofing of the vesicles (for diagnostic purposes) resulted in secondary bacterial infection. Conclusion The current report is the first series in the literature on herpetic whitlows in infants. We stress on the mode of transmission (from the mother) and establishing the diagnosis clinically. In these cases, no need for obtaining viral cultures or polymerase chain reaction; and no medications are required. Once the vesicles are disrupted, secondary bacterial infection is frequent and a combination of oral acyclovir and intravenous antibiotics will be required.

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