Development of DNA Aptamer as a β-Amyloid Aggregation Inhibitor

2020 ◽  
Vol 3 (12) ◽  
pp. 8611-8618
Author(s):  
Yan Zheng ◽  
Pei Wang ◽  
Shaoyuan Li ◽  
Xiuhua Geng ◽  
Liyuan Zou ◽  
...  
Keyword(s):  
Dna Aptamer ◽  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Aggregation Inhibitor

Synthesis of 5-chloro-3-[4-(3-diethylaminopropoxy)benzoyl]-2-(4-methoxyphenyl)benzofuran as a β-amyloid aggregation Inhibitor

2003 ◽  
Vol 26 (12) ◽  
pp. 985-989 ◽  
Author(s):  
Hong-Dae Choi ◽  
Pil-Ja Seo ◽  
Byeng-Wha Son ◽  
Byoung-Won Kang
Keyword(s):  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Aggregation Inhibitor

Synthesis of 2-(4-hydroxyphenyl)benzofurans and their application to β-amyloid aggregation inhibitor

2004 ◽  
Vol 27 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Hong-Dae Choi ◽  
Pil-Ja Seo ◽  
Byeng-Wha Son ◽  
Byoung Won Kang
Keyword(s):  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Aggregation Inhibitor

Аnticholinesterase and antioxidant activity of new binary conjugates of (с)-carbolines

2019 ◽  
Vol 484 (1) ◽  
pp. 104-108
Author(s):  
G. F. Makhaeva ◽  
E. F. Shevtsova ◽  
N. P. Boltneva ◽  
N. V. Kovaleva ◽  
E. V. Rudakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Anticholinesterase Activity ◽  
Amyloid Aggregation ◽  
Varying Length ◽  
Β Amyloid ◽  
New Compounds

This study presents the synthesis of binary tetrohydro-γ-carbolines with ditriazol spacers of varying length, which exhibit anticholinesterase and antioxidant activity, as compared to the original Dimebon prototype. Anticholinesterase activity suggests the potential ability of the new compounds to block β-amyloid aggregation induced by anticholinesterase, making them promising candidates for further research preparations for the treatment of Alzheimer's disease. Particular attention should be paid to the conjugate with an intertriazol hexamethylene spacer, which can be regarded as the leading compound in this series.

Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines

2012 ◽  
Vol 33 (3) ◽  
pp. 482-490 ◽  
Author(s):  
Shao-wei Wang ◽  
Yu-Jiong Wang ◽  
Ya-jing Su ◽  
Wei-wei Zhou ◽  
Shi-gao Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Proinflammatory Cytokines ◽  
Amyloid Aggregation ◽  
Β Amyloid

Role of Acetylcholinesterase in β-Amyloid Aggregation Studied by Accelerated Molecular Dynamics

2016 ◽  
Vol 7 (2) ◽  
pp. 396-402 ◽  
Author(s):  
Sofya V. Lushchekina ◽  
Ekaterina D. Kots ◽  
Dana A. Novichkova ◽  
Konstantin A. Petrov ◽  
Patrick Masson
Keyword(s):  
Molecular Dynamics ◽  
Amyloid Aggregation ◽  
Accelerated Molecular Dynamics ◽  
Β Amyloid
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