scholarly journals Retinol-Binding Protein Interferes with Transthyretin-Mediated β-Amyloid Aggregation Inhibition

Biochemistry ◽  
2018 ◽  
Vol 57 (33) ◽  
pp. 5029-5040
Author(s):  
Parth Mangrolia ◽  
Regina M. Murphy
Keyword(s):  
Binding Protein ◽  
Retinol Binding Protein ◽  
Amyloid Aggregation ◽  
Aggregation Inhibition ◽  
Β Amyloid

N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study

2020 ◽  
Vol 98 ◽  
pp. 103753 ◽  
Author(s):  
Carolina S. Marques ◽  
Óscar López ◽  
Donatella Bagetta ◽  
Elisabete P. Carreiro ◽  
Sabrina Petralla ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Aggregation Inhibition ◽  
Β Amyloid ◽  
Isatin Derivatives

The inhibitory effects of Escherichia coli maltose binding protein on β-amyloid aggregation and cytotoxicity

2013 ◽  
Vol 538 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Md. Golam Sharoar ◽  
Md. Shahnawaz ◽  
Md. Imamul Islam ◽  
Vijay Sankar Ramasamy ◽  
Song Yub Shin ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Binding Protein ◽  
Maltose Binding Protein ◽  
Amyloid Aggregation ◽  
Inhibitory Effects ◽  
Β Amyloid

scholarly journals Understanding Benefits of Curcumin on Cognitive Function from Molecular Aspect: A Review

2021 ◽  
pp. 1-7
Author(s):  
A. A. A. Putri Laksmidewi ◽  
Richard Suherlim
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
Low Grade ◽  
Molecular Aspect ◽  
Amyloid Aggregation ◽  
Neuroprotective Effects ◽  
Aggregation Inhibition ◽  
Β Amyloid ◽  
Over Time

Cognitive function has a significant impact on individuals’ quality of life. Over time, human cognitive function tends to decline. The importance of cognitive function in everyday life has led many researchers to seek alternative treatments to maintain and improve cognitive function. Some studies show that curcumin can improve cognitive function and prevent cognitive decline in humans.  This review focuses on the benefits of curcumin on cognitive function and the mechanism of how it works from molecular aspect. According to some studies, one of the factors leading to cognitive decline is chronic low-grade systemic inflammation. This review will focus on antioxidant, anti-inflammatory, neuroprotective effects, and β amyloid aggregation inhibition properties of curcumin that can improve cognitive function or delay cognitive decline. It is important to understand the basic reasons why curcumin can have benefits on cognitive function, this can be seen from the mechanisms that are reflected in the biomolecular aspect.

586-P: Vitreous and Serum Measurements of Retinol Binding Protein 3 in the Clinical Evaluation of Diabetic Retinopathy

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 586-P
Author(s):  
WARD FICKWEILER ◽  
HISASHI YOKOMIZO ◽  
KYOUNGMIN PARK ◽  
SAMANTHA M. PANIAGUA ◽  
I-HSIEN WU ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Clinical Evaluation ◽  
Binding Protein ◽  
Retinol Binding Protein

Аnticholinesterase and antioxidant activity of new binary conjugates of (с)-carbolines

2019 ◽  
Vol 484 (1) ◽  
pp. 104-108
Author(s):  
G. F. Makhaeva ◽  
E. F. Shevtsova ◽  
N. P. Boltneva ◽  
N. V. Kovaleva ◽  
E. V. Rudakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Anticholinesterase Activity ◽  
Amyloid Aggregation ◽  
Varying Length ◽  
Β Amyloid ◽  
New Compounds

This study presents the synthesis of binary tetrohydro-γ-carbolines with ditriazol spacers of varying length, which exhibit anticholinesterase and antioxidant activity, as compared to the original Dimebon prototype. Anticholinesterase activity suggests the potential ability of the new compounds to block β-amyloid aggregation induced by anticholinesterase, making them promising candidates for further research preparations for the treatment of Alzheimer's disease. Particular attention should be paid to the conjugate with an intertriazol hexamethylene spacer, which can be regarded as the leading compound in this series.

scholarly journals Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Chuyao Jin ◽  
Lizi Lin ◽  
Na Han ◽  
Zhiling Zhao ◽  
Zheng Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Binding Protein ◽  
First Trimester ◽  
Retinol Binding Protein ◽  
Second Trimester ◽  
Retinol Binding Protein 4 ◽  
Plasma Retinol

Abstract Background To assess the association between plasma retinol-binding protein 4 (RBP4) levels both in the first trimester and second trimester and risk of gestational diabetes mellitus (GDM). Methods Plasma RBP4 levels and insulin were measured among 135 GDM cases and 135 controls nested within the Peking University Birth Cohort in Tongzhou. Multivariable linear regression analysis was conducted to assess the influence of RBP4 levels on insulin resistance. Conditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence interval (CI) between RBP4 levels and risk of GDM. Results The GDM cases had significantly higher levels of RBP4 in the first trimester than controls (medians: 18.0 μg/L vs 14.4 μg/L; P < 0.05). Plasma RBP4 concentrations in the first and second trimester were associated with fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI) in the second trimester (all P < 0.001). With adjustment for diet, physical activity, and other risk factors for GDM, the risk of GDM increased with every 1-log μg/L increment of RBP4 levels, and the OR (95% CI) was 3.12 (1.08–9.04) for RBP4 in the first trimester and 3.38 (1.03–11.08) for RBP4 in the second trimester. Conclusions Plasma RBP4 levels both in the first trimester and second trimester were dose-dependently associated with increased risk of GDM.

Sign in / Sign up

Export Citation Format

Share Document