PLA2-Triggered Release of Drugs from Self-Assembled Lipid Tubules for Arthritis Treatments

2020 ◽  
Vol 3 (9) ◽  
pp. 6488-6496
Author(s):  
Qin Wang ◽  
Liming He ◽  
Donghao Fan ◽  
Wenlang Liang ◽  
Xiaochen Wang ◽  
...  
Keyword(s):  
Triggered Release ◽  
Self Assembled ◽  
Lipid Tubules

scholarly journals Novel fluorescent amphiphilic copolymer probes containing azo-tetraphenylethylene bridges for azoreductase-triggered release

2019 ◽  
Vol 3 (6) ◽  
pp. 1097-1104 ◽  
Author(s):  
Xiaojie Yuan ◽  
Zhe Wang ◽  
Lishan Li ◽  
Jiawei Yu ◽  
Yuqing Wang ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Fluorescent Probe ◽  
Amphiphilic Copolymer ◽  
Amphiphilic Block Copolymer ◽  
Triggered Release ◽  
Azo Reductase ◽  
Self Assembled

A novel AIE fluorescent probe of amphiphilic block copolymer PCL-TPE-Azo-PEG was successfully synthesized based on azo reductase response. The polymer can be self-assembled and showed fluorescence improvement during reductant-triggered release.

Direct Printing of Self-Assembled Lipid Tubules on Substrates

Langmuir ◽  
2008 ◽  
Vol 24 (9) ◽  
pp. 5113-5117 ◽  
Author(s):  
Yue Zhao ◽  
Jiyu Fang
Keyword(s):  
Direct Printing ◽  
Self Assembled ◽  
Lipid Tubules

scholarly journals Multifunctional DNA Nanomaterials for Biomedical Applications

2015 ◽  
Vol 2015 ◽  
pp. 1-21 ◽  
Author(s):  
Dick Yan Tam ◽  
Pik Kwan Lo
Keyword(s):  
Targeted Delivery ◽  
Materials Science ◽  
Drug Loading ◽  
Dna Nanotechnology ◽  
Control Release ◽  
Structural Features ◽  
Cellular Systems ◽  
Triggered Release ◽  
Self Assembled

The rapidly emerging DNA nanotechnology began with pioneer Seeman’s hypothesis that DNA not only can carry genetic information but also can be used as molecular organizer to create well-designed and controllable nanomaterials for applications in materials science, nanotechnology, and biology. DNA-based self-assembly represents a versatile system for nanoscale construction due to the well-characterized conformation of DNA and its predictability in the formation of base pairs. The structural features of nucleic acids form the basis of constructing a wide variety of DNA nanoarchitectures with well-defined shapes and sizes, in addition to controllable permeability and flexibility. More importantly, self-assembled DNA nanostructures can be easily functionalized to construct artificial functional systems with nanometer scale precision for multipurposes. Apparently scientists envision artificial DNA-based nanostructures as tool for drug loading andin vivotargeted delivery because of their abilities in selective encapsulation and stimuli-triggered release of cargo. Herein, we summarize the strategies of creating multidimensional self-assembled DNA nanoarchitectures and review studies investigating their stability, toxicity, delivery efficiency, loading, and control release of cargos in addition to their site-specific targeting and delivery of drug or cargo molecules to cellular systems.

Self-Assembled Lipid Tubules: Synthesis, Characterization, and Ordered Arrays

2006 ◽  
Vol 922 ◽  
Author(s):  
Yue Zhao ◽  
Nidhi Mahajan ◽  
Jiyu Fang
Keyword(s):  
Atomic Force Microscopy ◽  
Lipid Bilayer ◽  
Surface Patterning ◽  
The Self ◽  
Two Dimensional ◽  
Force Microscopy ◽  
Ordered Arrays ◽  
Atomic Force ◽  
Self Assembled ◽  
Lipid Tubules

AbstractThe rolling of lipid bilayer sheets into hollow cylindrical tubules have emerged as a group of interesting supramolecular nanostructures. Here, we image the self-assembled tubules of 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphochloline (DC8,9PC) with atomic force microscopy. Nanoscale ripple structures with a periodicity of ~ 200nm in the cylindrical lipid tubules are observed. We develop two simple methods based on microfluidic networks and surface patterning to produce two dimensional ordered arrays of parallel aligned lipid tubules on substrates.

Supramolecular colloidosomes: fabrication, characterisation and triggered release of cargo

2014 ◽  
Vol 50 (53) ◽  
pp. 7048-7051 ◽  
Author(s):  
Godwin Stephenson ◽  
Richard M. Parker ◽  
Yang Lan ◽  
Ziyi Yu ◽  
Oren A. Scherman ◽  
...  
Keyword(s):  
Guest Complex ◽  
Triggered Release ◽  
Microfluidic Droplets ◽  
Host Guest Complex ◽  
Self Assembled

Supramolecular colloidosomes are self-assembled at the interface of microfluidic droplets via a cucurbit[8]uril host–guest complex, allowing for triggered release of aqueous cargo.

Nanoscale Ripples in Self-Assembled Lipid Tubules

Langmuir ◽  
2006 ◽  
Vol 22 (5) ◽  
pp. 1973-1975 ◽  
Author(s):  
Nidhi Mahajan ◽  
Yue Zhao ◽  
Tianbao Du ◽  
Jiyu Fang
Keyword(s):  
Self Assembled ◽  
Lipid Tubules

Self-Assembled Cylindrical Lipid Tubules with a Birefringent Core

Small ◽  
2006 ◽  
Vol 2 (3) ◽  
pp. 364-367 ◽  
Author(s):  
Yue Zhao ◽  
Nidhi Mahaja ◽  
Jiyu Fang
Keyword(s):  
Self Assembled ◽  
Lipid Tubules

Radial Elasticity of Self-Assembled Lipid Tubules

ACS Nano ◽  
2008 ◽  
Vol 2 (7) ◽  
pp. 1466-1472 ◽  
Author(s):  
Yue Zhao ◽  
Karan Tamhane ◽  
Xuejun Zhang ◽  
Linan An ◽  
Jiyu Fang
Keyword(s):  
Self Assembled ◽  
Lipid Tubules
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