Fluorescein–Metal Hybrid Surfactant Conjugates as a Smart Material for Antimicrobial Photodynamic Therapy against Staphylococcus aureus

2020 ◽  
Vol 3 (7) ◽  
pp. 4674-4683 ◽  
Author(s):  
Preeti Garg ◽  
Gurpreet Kaur ◽  
Bunty Sharma ◽  
Ganga Ram Chaudhary
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Smart Material ◽  
Antimicrobial Photodynamic Therapy ◽  
Hybrid Surfactant

scholarly journals Efficiency of Antimicrobial Photodynamic Therapy with Photodithazine® on MSSA and MRSA Strains

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 869
Author(s):  
Beatriz Müller Nunes Souza ◽  
Juliana Guerra Pinto ◽  
André Henrique Correia Pereira ◽  
Alejandro Guillermo Miñán ◽  
Juliana Ferreira-Strixino
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Antimicrobial Photodynamic Therapy ◽  
Bacterial Inactivation ◽  
Bacterial Reduction ◽  
Complete Inactivation ◽  
Opportunistic Bacteria ◽  
Significant Difference ◽  
Mrsa Strains

Staphylococccus aureus is a ubiquitous and opportunistic bacteria associated with high mortality rates. Antimicrobial photodynamic therapy (aPDT) is based on the application of a light source and a photosensitizer that can interact with molecular oxygen, forming Reactive Oxygen Species (ROS) that result in bacterial inactivation. This study aimed to analyze, in vitro, the action of aPDT with Photodithazine® (PDZ) in methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) strains. The strains were incubated with PDZ at 25, 50, 75, and 100 mg/L for 15 min and irradiated with fluences of 25, 50, and 100 J/cm2. The internalization of PDZ was evaluated by confocal microscopy, the bacterial growth by counting the number of colony-forming units, as well as the bacterial metabolic activity post-aPDT and the production of ROS. In both strains, the photosensitizer was internalized; the production of ROS increased when the aPDT was applied; there was a bacterial reduction compared to the control at all the evaluated fluences and concentrations; and, in most parameters, it was obtained complete inactivation with significant difference (p < 0.05). The implementation of aPDT with PDZ in clinical strains of S. aureus has resulted in its complete inactivation, including the MRSA strains.

Antimicrobial photodynamic therapy in chronic osteomyelitis induced by Staphylococcus aureus: An in vitro and in vivo study

2012 ◽  
Author(s):  
João Alves dos Reis Júnior ◽  
Patrícia Nascimento de Assis ◽  
Garde^nia Matos Paraguassú ◽  
Isabele Cardoso Vieira de de Castro ◽  
Renan Ferreira Trindade ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Chronic Osteomyelitis ◽  
In Vivo Study ◽  
Antimicrobial Photodynamic Therapy

Bacterial viability after antimicrobial photodynamic therapy with curcumin on multiresistant Staphylococcus aureus

2019 ◽  
Vol 14 (9) ◽  
pp. 739-748 ◽  
Author(s):  
Mirian AA Freitas ◽  
André HC Pereira ◽  
Juliana G Pinto ◽  
Adriana Casas ◽  
Juliana Ferreira-Strixino
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Antimicrobial Photodynamic Therapy ◽  
Bacterial Viability
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