Antimicrobial photodynamic therapy for the decolonization of methicillin-resistant Staphylococcus aureus from the anterior nares

2009 ◽  
Author(s):  
Cale N. Street ◽  
Lisa Pedigo ◽  
Aaron Gibbs ◽  
Nicolas G. Loebel
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antimicrobial Photodynamic Therapy ◽  
Methicillin Resistant

Antimicrobial photodynamic therapy effectiveness against susceptible and methicillin-resistant Staphylococcus aureus biofilms

2020 ◽  
Vol 30 ◽  
pp. 101760
Author(s):  
Camilo Geraldo de Souza Teixeira ◽  
Paula Volpato Sanitá ◽  
Ana Paula Dias Ribeiro ◽  
Luana Mendonça Dias ◽  
Janaina Habib Jorge ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antimicrobial Photodynamic Therapy ◽  
Methicillin Resistant ◽  
Therapy Effectiveness

scholarly journals A Novel Dicationic Boron Dipyrromethene-based Photosensitizer for Antimicrobial Photodynamic Therapy against Methicillin-Resistant Staphylococcus aureus

2020 ◽  
Vol 28 ◽  
Author(s):  
Priyanga Dharmaratne ◽  
Ligang Yu ◽  
Roy Chi-Hang Wong ◽  
Ben Chun-Lap Chan ◽  
Kit-Man Lau ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Skin Irritation ◽  
Scientific Basis ◽  
Positive Control ◽  
Methicillin Resistant ◽  
Boron Dipyrromethene ◽  
Mrsa Strains

Background: We report herein the synthesis of a novel dicationic boron dipyrromethene derivative (compound 3) which is symmetrically substituted with two trimethylammonium styryl groups. Methods: The antibacterial photodynamic activity of compound 3 was determined against sixteen methicillin-resistant Staphylococcus aureus (MRSA) strains, including four ATCC type strains (ATCC 43300, ATCC BAA-42, ATCC BAA-43, and ATCC BAA-44), two mutant strains [AAC(6’)-APH(2”) and RN4220/pUL5054], and ten non-duplicate clinical strains of hospital- and communityassociated MRSA. Upon light irradiation, the minimum bactericidal concentrations of compound 3 were in the range of 1.56-50 µM against all the sixteen MRSA strains. Interestingly, compound 3 was not only more active than an analogue in which the ammonium groups are not directly connected to the pconjugated system (compound 4), but also showed significantly higher (p < 0.05) antibacterial potency than the clinically approved photosensitizer methylene blue. The skin irritation of compound 3 during topical application was tested on human 3-D skin constructs and proven to be non-irritant in vivo at concentrations below 1.250 mM. In the murine MRSA infected wound study, the colony forming unit reduction of compound 3 + PDT group showed significantly (p < 0.05) higher value (>2.5 log10) compared to other test groups except for the positive control. Conclusion: In conclusion, the present study provides a scientific basis for future development of compound 3 as a potent photosensitizer for photodynamic therapy for MRSA wound infection.

scholarly journals Bactericidal effect of photodynamic therapy against methicillin-resistant Staphylococcus aureus strain with the use of various porphyrin photosensitizers.

2007 ◽  
Vol 54 (3) ◽  
pp. 665-670 ◽  
Author(s):  
Mariusz Grinholc ◽  
Bozena Szramka ◽  
Katarzyna Olender ◽  
Alfreda Graczyk
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Bactericidal Effect ◽  
Aureus Strain ◽  
Methicillin Resistant ◽  
Essential Change ◽  
Log10 Unit ◽  
Porphyrin Photosensitizers ◽  
Unit Reduction

Photodynamic therapy (PDT) is based on photosensitizers activated by light of appropriate wavelength. Their activation leads to generation of singlet oxygen and free radicals responsible for the cytotoxic effect. The aim of this project was to compare the bactericidal effect of PDT using different porphyrin photosensitizers against a methicillin-resistant Staphylococcus aureus strain. Exogenous sensitizers (protoporphyrin IX and newly synthesized derivative, protoporphyrin diarginate) induced a 3 log10-unit reduction in bacterial viable counts. With the use of endogenous, ALA-induced porphyrins, a 1.6 log10-unit reduction was obtained. The sensitizers tested executed their antibacterial activity with no essential change in the antibiotic resistance pattern of the studied strain.

scholarly journals Photodynamic therapy for methicillin-resistant Staphylococcus aureus infection in a mouse skin abrasion model

2010 ◽  
Vol 42 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Tianhong Dai ◽  
George P. Tegos ◽  
Timur Zhiyentayev ◽  
Eleftherios Mylonakis ◽  
Michael R. Hamblin
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Mouse Skin ◽  
Methicillin Resistant ◽  
Aureus Infection ◽  
Skin Abrasion

Reduced methicillin-resistant Staphylococcus aureus biofilm formation in bone cavities by photodynamic therapy

2018 ◽  
Vol 21 ◽  
pp. 219-223 ◽  
Author(s):  
Thalita Santos Dantas Araújo ◽  
Paôlla Layanna Fernandes Rodrigues ◽  
Mariana Sousa Santos ◽  
Janeide Muritiba de Oliveira ◽  
Luciano Pereira Rosa ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Biofilm Formation ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant
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