Manganese-Doped Layered Double Hydroxide: A Biodegradable Theranostic Nanoplatform with Tumor Microenvironment Response for Magnetic Resonance Imaging-Guided Photothermal Therapy

2020 ◽  
Vol 3 (9) ◽  
pp. 5845-5855 ◽  
Author(s):  
Wensheng Xie ◽  
Zhenhu Guo ◽  
Qin Gao ◽  
Dan Wang ◽  
Kang Liang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tumor Microenvironment ◽  
Layered Double Hydroxide ◽  
Photothermal Therapy ◽  
Resonance Imaging ◽  
Double Hydroxide

Intelligent tumor microenvironment responsive nanotheranostic agent for T1/T2 dual-modal magnetic resonance imaging-guided and self-augmented photothermal therapy

2021 ◽  
Author(s):  
Junlie Yao ◽  
Fang Zheng ◽  
Fang Yang ◽  
Chenyang Yao ◽  
Jie Xing ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tumor Microenvironment ◽  
Thermal Ablation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Biological Applications ◽  
Resonance Imaging

Photothermal therapy (PTT), as a promising antineoplastic therapeutic stratagem, has been harnessed to restrain tumor through near-infrared (NIR) irradiation mediated thermal ablation. Nevertheless, its biological applications are hampered by the...

Tumor microenvironment-responsive multifunctional nanoplatform based on MnFe2O4-PEG for enhanced magnetic resonance imaging-guided hypoxic cancer radiotherapy

2021 ◽  
Vol 9 (6) ◽  
pp. 1625-1637 ◽  
Author(s):  
Zhenhu He ◽  
Haixiong Yan ◽  
Wenbin Zeng ◽  
Kai Yang ◽  
Pengfei Rong
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tumor Microenvironment ◽  
Resonance Imaging ◽  
Cancer Radiotherapy

A promising nanoplatform for the tumor microenvironment regulation, thus achieving magnetic resonance imaging precision-guided cancer radiotherapy sensitization.

Porous cobalt sulfide hollow nanospheres with tunable optical property for magnetic resonance imaging-guided photothermal therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (29) ◽  
pp. 14190-14200 ◽  
Author(s):  
Guoqiang Guan ◽  
Xin Wang ◽  
Xiaojuan Huang ◽  
Wenlong Zhang ◽  
Zhe Cui ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Optical Property ◽  
Magnetic Resonance ◽  
Photothermal Therapy ◽  
Cobalt Sulfide ◽  
Resonance Imaging ◽  
Hollow Nanospheres ◽  
Highly Efficient ◽  
Tunable Absorption

Simple, highly efficient, and safe porous cobalt sulfide hollow nanospheres with tunable absorption as a magnetic resonance imaging-guided photothermal theranostic platform.

scholarly journals Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging

Processes ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 462 ◽  
Author(s):  
Karina Nava Andrade ◽  
Gregorio Guadalupe Carbajal Arízaga ◽  
José Antonio Rivera Mayorga
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Molar Ratios ◽  
Magnetic Resonance Imaging Mri ◽  
Double Hydroxide ◽  
Double Hydroxides

In this work, we explore the synthesis of layered double hydroxide (LDH) particles containing different molar ratios of Gd3+ and Dy3+ cations. A single crystalline phase was obtained for Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH, and their efficiency as contrast agents was evaluated by T1- and T2-weighted magnetic resonance imaging (MRI). Both GdDy-LDHs exhibited longitudinal relaxivity (r1) higher than a commercial reference. The highest contrast in the T1 mode was achieved with the Zn2.0Al0.75Gd0.125Dy0.125-LDH, which contained the lowest concentration of lanthanides; this efficiency is related to the lowest amount of carbonate anions complexing the lanthanide sites. On the contrary, the best contrast in the T2 mode was achieved with Zn2.0Al0.5Gd0.25Dy0.25-LDH. Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH presented r2/r1 ratios of 7.9 and 22.5, respectively, indicating that the inclusion of gadolinium and dysprosium into layered structures is a promising approach to the development of efficient bimodal (T1/T2) MRI contrast agents.

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