Folic Acid-Conjugated pH and Redox-Sensitive Ellipsoidal Hybrid Magnetic Nanoparticles for Dual-Triggered Drug Release

2020 ◽  
Vol 3 (8) ◽  
pp. 4949-4961
Author(s):  
Gokcen Birlik Demirel ◽  
Ebru Aygul ◽  
Aydan Dag ◽  
Sezen Atasoy ◽  
Zeynep Cimen ◽  
...  
Keyword(s):  
Folic Acid ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Triggered Drug Release

scholarly journals Folic acid and deoxycholic acid derivative modified Fe3O4 nanoparticles for efficient pH-dependent drug release and multi-targeting against liver cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (63) ◽  
pp. 39804-39812
Author(s):  
Xiaoyu Wang ◽  
Qing Ma ◽  
Chaochao Wen ◽  
Tao Gong ◽  
Jing Li ◽  
...  
Keyword(s):  
Folic Acid ◽  
Magnetic Nanoparticles ◽  
Liver Cancer ◽  
Drug Release ◽  
Deoxycholic Acid ◽  
Drug Carrier ◽  
Liver Cancer Cells ◽  
Triggered Drug Release ◽  
Ph Dependent ◽  
Tumor Cell Killing

A nano-drug carrier, FDCA-FA-MNPs was constructed by modifying Fe3O4 magnetic nanoparticles (MNPs) with formyl deoxycholic acid (FDCA) and folic acid (FA) with double-targeting, pH-triggered drug release and excellent tumor cell killing efficiency.

Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy

2019 ◽  
Vol 7 (5) ◽  
pp. 1825-1832 ◽  
Author(s):  
Luying Shen ◽  
Shan Pan ◽  
Dechao Niu ◽  
Jianping He ◽  
Xiaobo Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Facile Synthesis ◽  
Triggered Drug Release ◽  
Facile Route

We develop a facile route to synthesize organosilica-capped mesoporous silica nanocarriers for efficient and safe redox-triggered tumor chemotherapy.

scholarly journals pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9222-9234
Author(s):  
Vy Anh Tran ◽  
Sang-Wha Lee
Keyword(s):  
Drug Release ◽  
Polyacrylic Acid ◽  
Acidic Ph ◽  
Zeolitic Imidazolate Framework ◽  
Triggered Drug Release

The ZIF8–Dox@PAA nanocarrier demonstrated pH-triggered drug release through the detachment of the PAA layer along with the destruction of ZIF8 framework in acidic pH environment.

PEG–PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy

2021 ◽  
Author(s):  
Snigdharani Panda ◽  
Chandra Sekhar Bhol ◽  
Sujit Kumar Bhutia ◽  
Sasmita Mohapatra
Keyword(s):  
Drug Release ◽  
Mesoporous Carbon ◽  
Laser Excitation ◽  
Outer Shell ◽  
Carbon Nanospheres ◽  
Nir Light ◽  
Triggered Drug Release ◽  
Hybrid Nanoparticle

A hybrid nanoparticle consisting of N-doped mesoporous carbon nanospheres as core and thermosensitive PEG–PEI as outer shell shows multiple therapeutic actions such as PTT, PDT and NIR sensitive drug release under single 980 nm laser excitation.

Imaging Laser-Triggered Drug Release from Gold Nanocages with Transient Absorption Lifetime Microscopy

2017 ◽  
Vol 9 (23) ◽  
pp. 19653-19661 ◽  
Author(s):  
Yongkui Xu ◽  
Qi Liu ◽  
Ruoyu He ◽  
Xianchong Miao ◽  
Minbiao Ji
Keyword(s):  
Drug Release ◽  
Transient Absorption ◽  
Gold Nanocages ◽  
Triggered Drug Release

Formulation development of folic acid conjugated PLGA nanoparticles for improved cytotoxicity of Caffeic acid phenethyl ester

2021 ◽  
Vol 09 ◽  
Author(s):  
Harshad S Kapare ◽  
Sathiyanarayanan L ◽  
Arulmozhi S ◽  
Kakasaheb Mahadik
Keyword(s):  
Folic Acid ◽  
Drug Release ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Therapeutic Effects ◽  
Formulation Development ◽  
Sustained Drug Release ◽  
Active Constituent

Background: Honey bee propolis is one of the natural product reported in various traditional systems of medicines including Ayurveda. Caffeic acid phenethyl ester (CAPE) is an active constituent of propolis which is well known for its anticancer potential. The therapeutic effects of CAPE are restricted owing to its less aqueous solubility and low bioavailability. Objective: In this study CAPE loaded folic acid conjugated nanoparticle system (CLFPN) was investigated to enhance solubility, achieve sustained drug release and improved cytotoxicity of CAPE. Methods: Formulation development, characterization and optimization were carried out by design of experiment approach. In vitro and in vivo cytotoxicity study was carried out for optimized formulations. Results: Developed nanoparticles showed particle size and encapsulation efficiency of 170 ± 2 - 195 ± 3 nm and 75.66 ± 1.52 - 78.80 ± 1.25 % respectively. Optimized formulation CLFPN showed sustained drug release over a period of 42 h. GI50 concentration was decreased by 46.09% for formulation as compared to CAPE in MCF-7 cells indicating targeting effect of CLFPN. An improved in vitro cytotoxic effect was reflected in in-vivo Daltons Ascites Lymphoma model by reducing tumor cells count. Conclusion: The desired nanoparticle characteristic with improved in vivo and in vitro cytotoxicity was shown by developed formulation. Thus it can be further investigated for biomedical applications.

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