Surface Ligand-Controlled Wavelength-Tunable Luminescence of Gold Nanoclusters: Cellular Imaging and Smart Fluorescent Probes for Amyloid Detection

2020 ◽  
Vol 3 (7) ◽  
pp. 4282-4293 ◽  
Author(s):  
Sangita Kundu ◽  
Biswajoy Ghosh ◽  
Sourav Nandi ◽  
Meghna Ghosh ◽  
Arghajit Pyne ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Gold Nanoclusters ◽  
Cellular Imaging ◽  
Wavelength Tunable ◽  
Surface Ligand

scholarly journals Pyridazino-1,3a,6a-Triazapentalenes as Versatile Fluorescent Probes: Impact of Their Post-Functionalization and Application for Cellular Imaging

2021 ◽  
Vol 22 (12) ◽  
pp. 6645
Author(s):  
Doina Sirbu ◽  
Nicolas Chopin ◽  
Ivana Martinić ◽  
Moussa Ndiaye ◽  
Svetlana Eliseeva ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Cross Coupling ◽  
Spectroscopic Properties ◽  
Cellular Imaging ◽  
Fluorescent Properties ◽  
Post Functionalization

Pyridazino-1,3a,6a-triazapentalenes (PyTAP) are compact fused 6/5/5 tricyclic scaffolds which exhibit promising fluorescent properties. Chemically stable, they can be post-functionalized using standard Pd-catalyzed cross-coupling chemistry. Several original PyTAP bearing additional unsaturated substituents in positions 2 and 8 were synthetized and their spectroscopic properties analyzed. They have been successfully tested as fluorescent probes for cellular imaging.

scholarly journals Synthesis of Exosome-Based Fluorescent Gold Nanoclusters for Cellular Imaging Applications

2021 ◽  
Vol 22 (9) ◽  
pp. 4433
Author(s):  
Eun Sung Lee ◽  
Byung Seok Cha ◽  
Seokjoon Kim ◽  
Ki Soo Park
Keyword(s):  
Photoelectron Spectroscopy ◽  
Low Cost ◽  
Stokes Shift ◽  
Gold Nanoclusters ◽  
Human Colon ◽  
Cellular Imaging ◽  
Metal Nanoclusters ◽  
Human Colon Cancer ◽  
X Ray ◽  
High Concentrations

In recent years, fluorescent metal nanoclusters have been used to develop bioimaging and sensing technology. Notably, protein-templated fluorescent gold nanoclusters (AuNCs) are attracting interest due to their excellent fluorescence properties and biocompatibility. Herein, we used an exosome template to synthesize AuNCs in an eco-friendly manner that required neither harsh conditions nor toxic chemicals. Specifically, we used a neutral (pH 7) and alkaline (pH 11.5) pH to synthesize two different exosome-based AuNCs (exo-AuNCs) with independent blue and red emission. Using field-emission scanning electron microscopy, energy dispersive X-ray microanalysis, nanoparticle tracking analysis, and X-ray photoelectron spectroscopy, we demonstrated that AuNCs were successfully formed in the exosomes. Red-emitting exo-AuNCs were found to have a larger Stokes shift and a stronger fluorescence intensity than the blue-emitting exo-AuNCs. Both exo-AuNCs were compatible with MCF-7 (human breast cancer), HeLa (human cervical cancer), and HT29 (human colon cancer) cells, although blue-emitting exo-AuNCs were cytotoxic at high concentrations (≥5 mg/mL). Red-emitting exo-AuNCs successfully stained the nucleus and were compatible with membrane-staining dyes. This is the first study to use exosomes to synthesize fluorescent nanomaterials for cellular imaging applications. As exosomes are naturally produced via secretion from almost all types of cell, the proposed method could serve as a strategy for low-cost production of versatile nanomaterials.

Isonicotinamide-Stabilized Gold Nanoclusters as Fluorescent Probes for the Determination of 2,4,6-Trinitrophenol

2021 ◽  
pp. 1-10
Author(s):  
Chao Zeng ◽  
Chenxia Xie ◽  
Min Zhang ◽  
Chengdu Cao ◽  
Luohua Guo ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Gold Nanoclusters

scholarly journals Precision at the nanoscale: on the structure and property evolution of gold nanoclusters

2018 ◽  
Vol 90 (9) ◽  
pp. 1409-1427 ◽  
Author(s):  
Chenjie Zeng
Keyword(s):  
Rational Design ◽  
Gold Nanoclusters ◽  
Molecular Structures ◽  
Structure And Property ◽  
Transformation Reaction ◽  
Composition And Structure ◽  
Complex Architectures ◽  
Surface Ligand ◽  
Surface Monolayers ◽  
Synthesis Composition

Abstract Chemists are often regarded as “architects”, who are capable of building up complex molecular structures in the ultrasmall-dimensional world. However, compared with organic chemistry, nanochemistry – which deals with nanoparticles in the size range from 1 to 100 nm – is less precise in terms of synthesis, composition, and structure. Such an imprecise nature of nanochemistry has impeded an in-depth understanding as well as rational control of structures and properties of nanomaterials. Motivated by this, thiolate-protected gold nanoclusters (denoted as Aun(SR)m) have recently emerged as a paradigm of atomically precise nanomaterials, in which all the nanoparticles are identical to each other with the same number of core atoms (n) and surface ligands (m) as well as the atomic arrangement. In this review, we provide a demonstration of how the precise nature of Aun(SR)m nanoclusters allows one to understand, decipher and discover some important, enigmatic and intriguing issues and phenomena in nanoscience, including (i) a precise nanoscale transformation reaction induced by surface ligand exchange, (ii) the total structures of crystalline metal phases and the self-assembled surface monolayers, (iii) the periodicities and quantum confinement in nanoclusters and (iv) the emergence of hierarchical complexity in the entire nanoparticle system. We expect that such an in-depth understanding will eventually lead to the rational design and precise engineering of complex architectures at the nanoscale.

Synthesis of 6,6′-Bis(O -4-arylethynylbenzoyl)-α,α-Trehaloses and Their Utilization as Fluorescent Probes for Cellular Imaging

2018 ◽  
Vol 2018 (26) ◽  
pp. 3444-3453
Author(s):  
Kurumi Kobayashi ◽  
Rumiko Saito ◽  
Kaori Udagawa ◽  
Naoko Miyano-Kurosaki ◽  
Naoto Asano ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Cellular Imaging

Novel blue-emitting gold nanoclusters confined in human hemoglobin, and their use as fluorescent probes for copper(II) and histidine

2014 ◽  
Vol 182 (5-6) ◽  
pp. 1131-1141 ◽  
Author(s):  
Mojtaba Shamsipur ◽  
Fatemeh Molaabasi ◽  
Maryam Shanehsaz ◽  
Ali Akbar Moosavi-Movahedi
Keyword(s):  
Fluorescent Probes ◽  
Gold Nanoclusters ◽  
Human Hemoglobin
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