scholarly journals Poly-l-Lactic Acid Nanotubes as Soft Piezoelectric Interfaces for Biology: Controlling Cell Attachment via Polymer Crystallinity

2020 ◽  
Vol 3 (4) ◽  
pp. 2140-2149 ◽  
Author(s):  
Michael Smith ◽  
Thomas Chalklen ◽  
Cathrin Lindackers ◽  
Yonatan Calahorra ◽  
Caitlin Howe ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Cell Attachment ◽  
Polymer Crystallinity

Poly(L-Lactic Acid-Co-Aspartic Acid): Interactive Polymers for Tissue Engineering

1995 ◽  
Vol 394 ◽  
Author(s):  
Jeffrey S. Hrkach ◽  
Jean Ou ◽  
Noah Lotan ◽  
Robert Langer
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Cell Growth ◽  
Aspartic Acid ◽  
Biodegradable Polymers ◽  
Cell Attachment ◽  
Biologically Active ◽  
Functional Sites ◽  
Support Cell ◽  
Enhance Cell Attachment

AbstractOne of the challenges in the field of tissue engineering is the development of optimal materials for use as scaffolds to support cell growth and tissue development. For this purpose, we are developing synthetic, biodegradable polymers with functional sites that provide the opportunity to covalently attach biologically active molecules to the polymers, so they can predictably interact with cells in a favorable manner to enhance cell attachment and growth. The preparation of poly(L-lactic acid-co-aspartic acid) comb-like graft copolymers from poly(L-lactic acid-co-β-benzyl-L-aspartate), and the casting of polymer films by solvent evaporation were carried out.

Electrospun Scaffolds Composed of Poly(L-lactic acid) and Hydroxyapatite

2011 ◽  
Vol 493-494 ◽  
pp. 872-877 ◽  
Author(s):  
G.N.P Rodriguez ◽  
L.R. Rodrigues ◽  
C.G.B.T. Dias ◽  
M.A. d´Ávila ◽  
C.A.C. Zavaglia
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Cell Attachment ◽  
Polymeric Materials ◽  
Porous Membranes ◽  
Electrospun Scaffolds ◽  
Bioactive Ceramic ◽  
Biomedical Field ◽  
Fibrous Membranes ◽  
Artificial Extracellular Matrix

Tissue engineering is an important emerging area for creating biological alternatives for harvested tissues, implants, and prostheses. Biocompatible and biodegradable polymeric materials are considered an important class of materials that can be used as scaffolds in tissue engineering applications. In this work, the system studied was nanocomposites of hydroxyapatite (HA) dispersed in a matrix of PLLA. Scaffolds have to present similar structure and also function as an artificial extracellular matrix for cell attachment and growth. Hydroxyapatite is a bioactive ceramic and has been used in applications of repairing bone tissue due to its biocompatibility and osteoconductivity. Poly(L- lactic acid) is a biodegradable and biocompatible polymer and has been used in different applications in the biomedical field. In this work, polymer solutions were prepared with different percentages of hydroxyapatite and porous membranes consisting of non-woven nanostructured fibers were obtained by electrospinning. The process parameters were: voltage of 13kV, flow rate of 0.5 ml/h and distance from the tip of the needle to the collector of 12 cm. By using these process parameter, fibrous membranes were obtained with different concentrations of HA (1.96, 4.76, 9 [wt %]). The morphology of the samples was observed by SEM and the characteristic physic-chemical were analyzed by XRF, XRD, DSC and FTIR.

Effect of polymer crystallinity on papaverine release from poly (l-lactic acid) matrix

1997 ◽  
Vol 49 (2-3) ◽  
pp. 207-215 ◽  
Author(s):  
Makoto Miyajima ◽  
Akiko Koshika ◽  
Jun'ichi Okada ◽  
Masaru Ikeda ◽  
Kenji Nishimura
Keyword(s):  
Lactic Acid ◽  
Polymer Crystallinity

Surface modification of poly(l-lactic acid) affects initial cell attachment, cell morphology, and cell growth

2005 ◽  
Vol 7 (4) ◽  
pp. 187-193 ◽  
Author(s):  
Manae Yamaguchi ◽  
Toshio Shinbo ◽  
Toshiyuki Kanamori ◽  
Pi-chao Wang ◽  
Motohiro Niwa ◽  
...  
Keyword(s):  
Surface Modification ◽  
Lactic Acid ◽  
Cell Growth ◽  
Cell Morphology ◽  
Cell Attachment ◽  
Initial Cell

Surface Engineering of Nano-fibrous Biodegradable Poly(L-lactic acid) Scaffolds for Tissue Engineering

2004 ◽  
Vol 823 ◽  
Author(s):  
Xiaohua Liu ◽  
Youngjun Won ◽  
Peter X. Ma
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Surface Engineering ◽  
Surface Composition ◽  
Cell Attachment ◽  
Pore Wall ◽  
Porous Scaffolds ◽  
Cell Numbers ◽  
Fibrous Scaffolds ◽  
Surface Modified

AbstractThe architectural design and surface properties of scaffolds are important aspects in tissue engineering. The porous scaffolds accommodate cells and guide their growth, while the surface nature of the scaffolds can directly affect cell attachment, proliferation, and ultimately neo tissue regeneration. In this work, a highly porous poly(L-lactic acid) (PLLA) scaffold with nano-fibrous pore wall architecture has been fabricated by mimicking the structure of natural collagen using a novel thermally induced phase separation method developed in our group. A universally effective surface modification method was developed, and gelatin was successfully grafted onto the surface of nano-fibrous PLLA scaffolds by entrapment procedure. The surface composition, morphology, and properties were examined using ATR-FTIR, XPS and SEM. The surface coverage of gelatin on the PLLA surface was as high as 39.4%. MC3T3-E1 osteoprogenitor cells were cultured for 6 weeks in solid-walled PLLA scaffolds, nano-fibrous PLLA scaffolds, and surface-modified nano-fibrous PLLA scaffolds, respectively. The osteoblasts proliferated in all three types of scaffolds, but the cell numbers were always significantly higher in the surface-modified nano-fibrous scaffolds than in the other two types of scaffolds, and the cell numbers in nano-fibrous scaffolds were higher than that in the solid-walled scaffolds. These results demonstrate that the surface-modified nano-fibrous architecture could serve as a superior scaffold for tissue engineering.

Fabrication and characterization of ultrathin spin-coated poly(L-lactic acid) films suitable for cell attachment and curcumin loading

2020 ◽  
Vol 15 (6) ◽  
pp. 065022
Author(s):  
Viktoryia Kulikouskaya ◽  
Ihnat Chyshankou ◽  
Sergei Pinchuk ◽  
Irina Vasilevich ◽  
Igor Volotovski ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Cell Attachment ◽  
Fabrication And Characterization

Development of Cartilage and Bone During Formation of Phalanges by Tissue Engineering

1999 ◽  
Vol 5 (S2) ◽  
pp. 378-379
Author(s):  
W. Landis ◽  
N. Isogai ◽  
J. Vacanti
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Congenital Malformations ◽  
Flat Surface ◽  
Bone Cells ◽  
Cell Attachment ◽  
Organ Function ◽  
Tendon Cells ◽  
Specific Shape ◽  
Different Sources

Treatment of human congenital malformations and for loss of tissue or organ function is a serious clinical concern, frequently supported by harvesting autogenous tissue for reconstructive surgery. This paper summarizes an alternate approach through novel tissue engineering methods and describes cell-polymer composites that could be fundamental in developing advances for digit and joint replacement. The work utilizes cells from different sources transplanted on biodegradable polymer matrices to form structures with defined shape, morphological features and composition resembling those of human phalanges and intact joints.Polyglycolic acids (PGA) fibers (Albany International, Mansfield, MA) 15 μm in diameter were used as a mesh support for cell attachment and matrix formation. For cartilage and tendon cells, PGA alone served as a flat surface without specific shape. For bone cells, PGA was copolymerized with poly-L-lactic acid (PLLA) (Polysciences, Warrington, PA) and shaped after a human phalanx molded from cadaveric distal and middle phalangeal bones. Polymers were sterilized with ethylene oxide before use.

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