Practical Synthetic Method for the Preparation of Pyrone Diesters: An Efficient Synthetic Route for the Synthesis of Dolutegravir Sodium

2019 ◽  
Vol 23 (4) ◽  
pp. 565-570 ◽  
Author(s):  
Tatsuro Yasukata ◽  
Moriyasu Masui ◽  
Fumiya Ikarashi ◽  
Kazuya Okamoto ◽  
Takanori Kurita ◽  
...  
Keyword(s):  
Synthetic Method ◽  
Synthetic Route

Size-tunable and scalable synthesis of uniform copper nanocrystals

RSC Advances ◽  
2015 ◽  
Vol 5 (4) ◽  
pp. 2756-2761 ◽  
Author(s):  
Hwansu Sim ◽  
Jihwan Lee ◽  
Taekyung Yu ◽  
Kyungpil Kim ◽  
Seong Jun Lee ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Synthetic Method ◽  
Synthetic Route ◽  
Scalable Synthesis

A facile and scalable synthetic route to uniform Cu nanocrystals with tunable sizes in the range of 20–100 nm based on an ethylene glycol-assisted synthetic method was developed.

scholarly journals Synthetic Route to Glycosyl β-1C-(phosphino)-phosphonates as Unprecedented Stable Glycosyl Diphosphate Analogs and Their Preliminary Biological Evaluation

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4969
Author(s):  
Michaël Bosco ◽  
Su-Jin Paik ◽  
Patricia Busca ◽  
Stuart E. H. Moore ◽  
Christine Gravier-Pelletier
Keyword(s):  
Alkaline Phosphatase ◽  
Double Bond ◽  
Biological Evaluation ◽  
Synthetic Method ◽  
Synthetic Route ◽  
Stereoselective Addition

The synthesis of glycosyl-β-1C-(phosphino)-phosphonates is a challenge since it has not yet been described. In this paper, we report an innovative synthetic method for their preparation from Glc-, Man-, and GlcNAc- lactone derivatives. The proposed original strategy involves the addition of the corresponding δ-hexonolactones onto the dianion of (methylphosphino) phosphonate as a key step, followed by dehydration and stereoselective addition of dihydrogen on the resulting double bond. Final deprotection provides the new glycosyl diphosphate analogs in 35%, 36%, and 10% yield over 6 steps from the corresponding δ-hexonolactones. The synthetized compounds were evaluated as inhibitors of phosphatase and diphosphatase activities and found to have complex concentration-dependent activatory and inhibitory properties on alkaline phosphatase. The synthetized tools should be useful to study other enzymes such as transferases.

Efficient and Eco-Friendly Synthesis of Fluorenone Azines by Using Sulphated Titania Acid Catalyst

2015 ◽  
Vol 58 ◽  
pp. 137-143 ◽  
Author(s):  
V. Arun ◽  
K.R. Sankaran
Keyword(s):  
Reaction Time ◽  
Acid Catalyst ◽  
Recyclable Catalyst ◽  
Synthetic Method ◽  
Synthetic Route ◽  
Operating Method

Conjugated unsymmetrical azines have been synthesized in the presence of acid catalyst sulphated-titania (TiO2-SO42-) from fluorenone hydrazone with substituted aldehydes and acetophenones by using mortar and pestle. The scope of present synthetic route avoid in solvents, simple operating method and shorter reaction time. Special feature of synthetic method is recyclable catalyst for all in reactions.

Highly stereoselective one-pot construction of trisubstituted tetrahydro-β-carboline-fused diketopiperazines: a synthetic route towards cialis analogues

RSC Advances ◽  
2014 ◽  
Vol 4 (72) ◽  
pp. 38159-38163 ◽  
Author(s):  
Mouhamad Jida ◽  
Dirk Tourwé ◽  
Steven Ballet
Keyword(s):  
Synthetic Method ◽  
Synthetic Route ◽  
One Pot

A facile and efficient synthetic method for the stereoselective preparation of trisubstituted tetrahydro-β-carboline-fused diketopiperazine derivatives is reported.

Electrochemically activated solid synthesis: an alternative solid-state synthetic method

2018 ◽  
Vol 47 (41) ◽  
pp. 14604-14611 ◽  
Author(s):  
Junnan Liu ◽  
Henrik Lyder Andersen ◽  
Othman K. Al Bahri ◽  
Saroj Bhattacharyya ◽  
Aditya Rawal ◽  
...  
Keyword(s):  
Solid State ◽  
Synthetic Method ◽  
Thermal Treatments ◽  
Synthetic Route ◽  
Electrochemical Discharge ◽  
Solid Synthesis

Electrochemical discharge followed by thermal treatments leads to the generation of unconventional phases upon heating, an alternative synthetic route.

scholarly journals An Efficient Protocol for the Production of Pymetrozine via a New Synthetic Strategy

2018 ◽  
Vol 42 (8) ◽  
pp. 434-438
Author(s):  
Qifan Zhou ◽  
Fangyu Du ◽  
Yajie Shi ◽  
Wenqiang Liu ◽  
Dongdong Liu ◽  
...  
Keyword(s):  
Dimethyl Carbonate ◽  
Scale Up ◽  
Total Yield ◽  
Synthetic Method ◽  
Synthetic Route ◽  
Environmental Friendliness ◽  
Synthetic Strategy

A practical four-step synthesis of pymetrozine is reported, starting from a green chemical dimethyl carbonate and using the key intermediate methyl (E)-1-(2-oxopropyl)-2-(pyridin-3-ylmethylene)hydrazine-1-carboxylate. The main advantages of the route include inexpensive starting materials, environmental friendliness, short synthetic route, easy-to-use synthetic method and acceptable overall yield. A scale-up experiment was carried out to provide pymetrozine with 99.84% purity in 53.2% total yield.

An efficient synthetic route to 1,3-bis(arylethynyl)isobenzofuran using alkoxybenzocyclobutenone as a reactive platform

2014 ◽  
Vol 12 (48) ◽  
pp. 9773-9776 ◽  
Author(s):  
Kenta Asahina ◽  
Suguru Matsuoka ◽  
Ryosuke Nakayama ◽  
Toshiyuki Hamura
Keyword(s):  
Synthetic Method ◽  
Synthetic Route

An efficient synthetic method of 1,3-bis(arylethynyl)isobenzofurans is developed.

Synthesis of Azepine- or Azocine-Embedded Hexabenzocoronene-Based Nanographenes

Synlett ◽  
2021 ◽  
Author(s):  
Bin Ma ◽  
Ming-Jun Xiao ◽  
Pi-Jin Liu ◽  
Peng An
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Membered Ring ◽  
Synthetic Methods ◽  
Synthetic Method ◽  
Synthetic Route ◽  
Heteroatom Doping ◽  
Large Group ◽  
Planar Structures ◽  
Polycyclic Aromatic

Classical polycyclic aromatic hydrocarbons (PAHs) are a large group of π-conjugated planar structures. To explore more properties of PAHs, new structures were designed including nonplanar topologies and heteroatom-doping moieties. As an important nanographene (NG) unit, hexabenzocoronene (HBC) and its derivatives have been intensively researched. Numbers of HBC-based nonplanar NGs were developed and the heteroatom-doped HBC-based NGs have been designed and synthesized as well. Herein, we synthetically summarized some synthetic methods for seven- or eight-membered ring containing HBC-based NGs, and discussed our newly synthesized azepine- or azocine-embedded NGs by using a modified synthetic route and a traditional Müllen’s synthetic method, respectively.

Indirect synthetic route to α-l-fucosides via highly stereoselective construction of α-l-galactosides followed by C6-deoxygenation

2020 ◽  
Vol 18 (26) ◽  
pp. 5017-5033
Author(s):  
Hirotaka Tomida ◽  
Takuya Matsuhashi ◽  
Hide-Nori Tanaka ◽  
Naoko Komura ◽  
Hiromune Ando ◽  
...  
Keyword(s):  
Synthetic Method ◽  
Synthetic Route ◽  
Broad Applicability ◽  
Naturally Occurring

The indirect synthetic method for α-l-fucosides has been developed and its broad applicability to naturally occurring α-l-fucosides has been demonstrated.

Practical and Scalable Synthetic Method for Preparation of Dolutegravir Sodium: Improvement of a Synthetic Route for Large-Scale Synthesis

2019 ◽  
Vol 23 (4) ◽  
pp. 558-564 ◽  
Author(s):  
Yasunori Aoyama ◽  
Toshikazu Hakogi ◽  
Yuki Fukui ◽  
Daisuke Yamada ◽  
Takao Ooyama ◽  
...  
Keyword(s):  
Large Scale ◽  
Synthetic Method ◽  
Synthetic Route ◽  
Large Scale Synthesis
Sign in / Sign up

Export Citation Format

Share Document