Indirect synthetic route to α-l-fucosides via highly stereoselective construction of α-l-galactosides followed by C6-deoxygenation

2020 ◽  
Vol 18 (26) ◽  
pp. 5017-5033
Author(s):  
Hirotaka Tomida ◽  
Takuya Matsuhashi ◽  
Hide-Nori Tanaka ◽  
Naoko Komura ◽  
Hiromune Ando ◽  
...  
Keyword(s):  
Synthetic Method ◽  
Synthetic Route ◽  
Broad Applicability ◽  
Naturally Occurring

The indirect synthetic method for α-l-fucosides has been developed and its broad applicability to naturally occurring α-l-fucosides has been demonstrated.

Size-tunable and scalable synthesis of uniform copper nanocrystals

RSC Advances ◽  
2015 ◽  
Vol 5 (4) ◽  
pp. 2756-2761 ◽  
Author(s):  
Hwansu Sim ◽  
Jihwan Lee ◽  
Taekyung Yu ◽  
Kyungpil Kim ◽  
Seong Jun Lee ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Synthetic Method ◽  
Synthetic Route ◽  
Scalable Synthesis

A facile and scalable synthetic route to uniform Cu nanocrystals with tunable sizes in the range of 20–100 nm based on an ethylene glycol-assisted synthetic method was developed.

scholarly journals Synthetic Route to Glycosyl β-1C-(phosphino)-phosphonates as Unprecedented Stable Glycosyl Diphosphate Analogs and Their Preliminary Biological Evaluation

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4969
Author(s):  
Michaël Bosco ◽  
Su-Jin Paik ◽  
Patricia Busca ◽  
Stuart E. H. Moore ◽  
Christine Gravier-Pelletier
Keyword(s):  
Alkaline Phosphatase ◽  
Double Bond ◽  
Biological Evaluation ◽  
Synthetic Method ◽  
Synthetic Route ◽  
Stereoselective Addition

The synthesis of glycosyl-β-1C-(phosphino)-phosphonates is a challenge since it has not yet been described. In this paper, we report an innovative synthetic method for their preparation from Glc-, Man-, and GlcNAc- lactone derivatives. The proposed original strategy involves the addition of the corresponding δ-hexonolactones onto the dianion of (methylphosphino) phosphonate as a key step, followed by dehydration and stereoselective addition of dihydrogen on the resulting double bond. Final deprotection provides the new glycosyl diphosphate analogs in 35%, 36%, and 10% yield over 6 steps from the corresponding δ-hexonolactones. The synthetized compounds were evaluated as inhibitors of phosphatase and diphosphatase activities and found to have complex concentration-dependent activatory and inhibitory properties on alkaline phosphatase. The synthetized tools should be useful to study other enzymes such as transferases.

Efficient and Eco-Friendly Synthesis of Fluorenone Azines by Using Sulphated Titania Acid Catalyst

2015 ◽  
Vol 58 ◽  
pp. 137-143 ◽  
Author(s):  
V. Arun ◽  
K.R. Sankaran
Keyword(s):  
Reaction Time ◽  
Acid Catalyst ◽  
Recyclable Catalyst ◽  
Synthetic Method ◽  
Synthetic Route ◽  
Operating Method

Conjugated unsymmetrical azines have been synthesized in the presence of acid catalyst sulphated-titania (TiO2-SO42-) from fluorenone hydrazone with substituted aldehydes and acetophenones by using mortar and pestle. The scope of present synthetic route avoid in solvents, simple operating method and shorter reaction time. Special feature of synthetic method is recyclable catalyst for all in reactions.

Highly stereoselective one-pot construction of trisubstituted tetrahydro-β-carboline-fused diketopiperazines: a synthetic route towards cialis analogues

RSC Advances ◽  
2014 ◽  
Vol 4 (72) ◽  
pp. 38159-38163 ◽  
Author(s):  
Mouhamad Jida ◽  
Dirk Tourwé ◽  
Steven Ballet
Keyword(s):  
Synthetic Method ◽  
Synthetic Route ◽  
One Pot

A facile and efficient synthetic method for the stereoselective preparation of trisubstituted tetrahydro-β-carboline-fused diketopiperazine derivatives is reported.

scholarly journals Synthesis of Natural Products and the Development of Synthetic Methodology: The Case Study of (–)-Atrop-abyssomicin C

2017 ◽  
Vol 12 (8) ◽  
pp. 1934578X1701200
Author(s):  
Filip Bihelovic ◽  
Bojan Vulovic ◽  
Radomir N. Saicic
Keyword(s):  
Natural Products ◽  
Synthetic Route ◽  
Synthetic Methodology ◽  
General Applicability ◽  
Total Syntheses ◽  
New Methods ◽  
Naturally Occurring

During our attempt to follow the planned synthetic route to the naturally occurring antibiotic (–)- atrop-abyssomicin C, we encountered two shortcomings, which forced us to reconsider our tactics and find new methods to overcome the problems. These methods turned out to be of general applicability, as demonstrated later in total syntheses of two other natural products: (+)-allokainic acid and (-)-gabosine H. The paper provides a brief account of these endeavors.

Electrochemically activated solid synthesis: an alternative solid-state synthetic method

2018 ◽  
Vol 47 (41) ◽  
pp. 14604-14611 ◽  
Author(s):  
Junnan Liu ◽  
Henrik Lyder Andersen ◽  
Othman K. Al Bahri ◽  
Saroj Bhattacharyya ◽  
Aditya Rawal ◽  
...  
Keyword(s):  
Solid State ◽  
Synthetic Method ◽  
Thermal Treatments ◽  
Synthetic Route ◽  
Electrochemical Discharge ◽  
Solid Synthesis

Electrochemical discharge followed by thermal treatments leads to the generation of unconventional phases upon heating, an alternative synthetic route.

A Short Synthetic Route to Benzofurans. Syntheses of Naturally Occurring Euparin and Related Compounds

Heterocycles ◽  
1996 ◽  
Vol 43 (1) ◽  
pp. 101 ◽  
Author(s):  
Masao Tsukayama ◽  
Akihiro Sogawa ◽  
Hiroshi Nozaki ◽  
Mitsuru Nakayama
Keyword(s):  
Synthetic Route ◽  
Naturally Occurring ◽  
Related Compounds

An expedient and efficient synthetic route to some naturally occurring polyfunctional naphthazarins

2001 ◽  
Vol 42 (50) ◽  
pp. 8915-8917 ◽  
Author(s):  
Christina L.L Chai ◽  
John A Elix ◽  
Felicity K.E Moore
Keyword(s):  
Synthetic Route ◽  
Naturally Occurring
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