Stereoselective Bulk Synthesis of CCR2 Antagonist BMS-741672: Assembly of an All-cis(S,R,R)-1,2,4-Triaminocyclohexane (TACH) Core via Sequential Heterogeneous Asymmetric Hydrogenations

2016 ◽  
Vol 20 (11) ◽  
pp. 1949-1966 ◽  
Author(s):  
Joerg Deerberg ◽  
Siva J. Prasad ◽  
Chris Sfouggatakis ◽  
Martin D. Eastgate ◽  
Yu Fan ◽  
...  
Keyword(s):  
Asymmetric Hydrogenations ◽  
Ccr2 Antagonist

Analgesic effects evoked by a CCR2 antagonist or an anti-CCL2 antibody in inflamed mice

2016 ◽  
Vol 30 (3) ◽  
pp. 235-247 ◽  
Author(s):  
María Llorián-Salvador ◽  
Marta Pevida ◽  
Sara González-Rodríguez ◽  
Ana Lastra ◽  
María-Teresa Fernández-García ◽  
...  
Keyword(s):  
Analgesic Effects ◽  
Ccr2 Antagonist

New chiral phosphorus ligands with spirobiindane backbone for asymmetric hydrogenations

2005 ◽  
Vol 77 (12) ◽  
pp. 2121-2132 ◽  
Author(s):  
Jian-Hua Xie ◽  
Shou-Fei Zhu ◽  
Yu Fu ◽  
Ai-Guo Hu ◽  
Qi-Lin Zhou
Keyword(s):  
Phosphorus Ligands ◽  
Highly Efficient ◽  
Asymmetric Hydrogenations

Chiral spiro phosphorus ligands including monophosphoramidites and diphosphines, which contained 1,1'-spirobiindane as a backbone, were designed and synthesized. These spiro ligands were proven to be highly efficient for rhodium- and ruthenium-catalyzed asymmetric hydrogenations of prochiral olefins and ketones with excellent enantioselectivities.

scholarly journals Reversal of Vascular Macrophage Accumulation and Hypertension by a CCR2 Antagonist in Deoxycorticosterone/Salt-Treated Mice

Hypertension ◽  
2012 ◽  
Vol 60 (5) ◽  
pp. 1207-1212 ◽  
Author(s):  
Christopher T. Chan ◽  
Jeffrey P. Moore ◽  
Klaudia Budzyn ◽  
Elizabeth Guida ◽  
Henry Diep ◽  
...  
Keyword(s):  
Ccr2 Antagonist ◽  
Macrophage Accumulation

Developing chiral phosphorus ligands for asymmetric hydrogenations

2010 ◽  
Vol 82 (7) ◽  
pp. 1429-1441 ◽  
Author(s):  
Wei Li ◽  
Guohua Hou ◽  
Xianfeng Sun ◽  
Gao Shang ◽  
Weicheng Zhang ◽  
...  
Keyword(s):  
Phosphine Ligands ◽  
Chiral Ligands ◽  
Phosphorus Ligands ◽  
Keto Esters ◽  
Asymmetric Hydrogenations ◽  
Dehydroamino Acid

Chiral rigid and electron-donating phosphocyclic phosphine ligands and modular atropisomeric biaryl phosphine ligands were designed and synthesized. The performance of these chiral ligands in the asymmetric hydrogenations of prochiral dehydroamino acid derivatives, enamides, imines, keto esters, and ketones has been demonstrated to be excellent.

Asymmetric Hydrogenations of Acetophenone and Its Derivatives over RuRh/γ-Al2O3 Modified by (1S,2S)-DPEN and PPh3

2007 ◽  
Vol 23 (4) ◽  
pp. 479-483 ◽  
Author(s):  
D LIU ◽  
W XIONG ◽  
C YANG ◽  
J WANG ◽  
H CHEN ◽  
...  
Keyword(s):  
Asymmetric Hydrogenations

ChemInform Abstract: Synthesis of Chiral Rh-BICHEP Complexes, Highly Efficient Catalysts for Asymmetric Hydrogenations.

ChemInform ◽  
2010 ◽  
Vol 23 (21) ◽  
pp. no-no
Author(s):  
T. CHIBA ◽  
A. MIYASHITA ◽  
H. NOHIRA ◽  
H. TAKAYA
Keyword(s):  
Highly Efficient ◽  
Asymmetric Hydrogenations
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