A Solvent-Free Base Liberation of a Tertiary Aminoalkyl Halide by Flow Chemistry

2016 ◽  
Vol 20 (12) ◽  
pp. 2043-2049 ◽  
Author(s):  
Michael J. Pedersen ◽  
Tommy Skovby ◽  
Michael J. Mealy ◽  
Kim Dam-Johansen ◽  
Søren Kiil
Keyword(s):  
Flow Chemistry ◽  
Solvent Free ◽  
Free Base

scholarly journals A solvent-free, base-catalyzed domino reaction towards trifluoromethylated benzenes from bio-based methyl coumalate

2018 ◽  
Vol 20 (7) ◽  
pp. 1491-1498 ◽  
Author(s):  
Liang Chang ◽  
Nadja Klipfel ◽  
Luc Dechoux ◽  
Serge Thorimbert
Keyword(s):  
Solvent Free ◽  
Domino Reaction ◽  
Free Base ◽  
High Yields

An efficient and sustainable method to prepare pharmaceutically important trifluoromethyl-benzenes from bio-based methyl coumalate in high yields, in a solvent-free tBuOK-catalyzed domino sequence.

Aluminium complex as an efficient catalyst for the chemo-selective reduction of amides to amines

2019 ◽  
Vol 48 (31) ◽  
pp. 11978-11984 ◽  
Author(s):  
Suman Das ◽  
Himadri Karmakar ◽  
Jayeeta Bhattacharjee ◽  
Tarun K. Panda
Keyword(s):  
Selective Reduction ◽  
Solvent Free ◽  
Free Base ◽  
Efficient Catalyst ◽  
Mild Conditions ◽  
Earth Abundant

Catalytic chemo-selective reduction of tert-amides with pinacolborane (HBpin) to furnish the corresponding tert-amines using an Earth-abundant Al complex under solvent-free, base-free and mild conditions is reported.

scholarly journals Ozone-Mediated Amine Oxidation and Beyond: A Solvent Free, Flow-Chemistry Approach

2021 ◽  
Author(s):  
Eric Skrotzki ◽  
Jaya Kishore Vandavasi ◽  
Stephen Newman
Keyword(s):  
Organic Molecules ◽  
Flow Chemistry ◽  
Packed Bed ◽  
High Reactivity ◽  
Solvent Free ◽  
Packed Bed Reactor ◽  
Primary Amines ◽  
Amine Oxidation ◽  
Synthetic Utility ◽  
Free Oxidation

Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to over-oxidize organic molecules, including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time of this reaction to achieve improved control and chemoselectivity over this challenging reaction. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C–H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.<br>

Solvent-free synthesis of phthalocyanines

2003 ◽  
Vol 07 (08) ◽  
pp. 548-550 ◽  
Author(s):  
Shive M. S. Chauhan ◽  
Kandadai A. Srinivas ◽  
Pravin K. Srivastava ◽  
Bishawabhusan Sahoo
Keyword(s):  
Solid Phase ◽  
Ammonium Molybdate ◽  
Solvent Free ◽  
Free Base ◽  
Basic Alumina ◽  
Phthalic Acids ◽  
Solvent Free Synthesis ◽  
Phthalic Anhydrides

Clean and efficient microwave assissted solid phase cyclocondensation of various substituted phthalic anhydrides, phthalic acids, phthalimide and phthalonitrile with urea in the presence of basic alumina forms free-base phthalocyanines in 15-79% yields with and without ammonium molybdate as a catalyst.

Solvent free base catalysis and transesterification over basic functionalised Metal-Organic Frameworks

2009 ◽  
Vol 11 (11) ◽  
pp. 1729 ◽  
Author(s):  
Marie Savonnet ◽  
Sonia Aguado ◽  
Ugo Ravon ◽  
Delphine Bazer-Bachi ◽  
Vincent Lecocq ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Solvent Free ◽  
Base Catalysis ◽  
Free Base ◽  
Metal Organic

scholarly journals Ozone-Mediated Amine Oxidation and Beyond: A Solvent Free, Flow-Chemistry Approach

2021 ◽  
Author(s):  
Eric Skrotzki ◽  
Jaya Kishore Vandavasi ◽  
Stephen Newman
Keyword(s):  
Organic Molecules ◽  
Flow Chemistry ◽  
Packed Bed ◽  
High Reactivity ◽  
Solvent Free ◽  
Packed Bed Reactor ◽  
Primary Amines ◽  
Amine Oxidation ◽  
Synthetic Utility ◽  
Free Oxidation

Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to over-oxidize organic molecules, including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time of this reaction to achieve improved control and chemoselectivity over this challenging reaction. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C–H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.<br>

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