Ozone-Mediated Amine Oxidation and Beyond: A Solvent-Free, Flow-Chemistry Approach

2021 ◽  
Author(s):  
Eric A. Skrotzki ◽  
Jaya Kishore Vandavasi ◽  
Stephen G. Newman
Keyword(s):  
Flow Chemistry ◽  
Solvent Free ◽  
Free Flow ◽  
Amine Oxidation

scholarly journals Ozone-Mediated Amine Oxidation and Beyond: A Solvent Free, Flow-Chemistry Approach

2021 ◽  
Author(s):  
Eric Skrotzki ◽  
Jaya Kishore Vandavasi ◽  
Stephen Newman
Keyword(s):  
Organic Molecules ◽  
Flow Chemistry ◽  
Packed Bed ◽  
High Reactivity ◽  
Solvent Free ◽  
Packed Bed Reactor ◽  
Primary Amines ◽  
Amine Oxidation ◽  
Synthetic Utility ◽  
Free Oxidation

Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to over-oxidize organic molecules, including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time of this reaction to achieve improved control and chemoselectivity over this challenging reaction. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C–H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.<br>

scholarly journals Ozone-Mediated Amine Oxidation and Beyond: A Solvent Free, Flow-Chemistry Approach

2021 ◽  
Author(s):  
Eric Skrotzki ◽  
Jaya Kishore Vandavasi ◽  
Stephen Newman
Keyword(s):  
Organic Molecules ◽  
Flow Chemistry ◽  
Packed Bed ◽  
High Reactivity ◽  
Solvent Free ◽  
Packed Bed Reactor ◽  
Primary Amines ◽  
Amine Oxidation ◽  
Synthetic Utility ◽  
Free Oxidation

Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to over-oxidize organic molecules, including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time of this reaction to achieve improved control and chemoselectivity over this challenging reaction. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C–H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.<br>

Solvent-free flow synthesis of [OMIM]Br in a microreactor

2021 ◽  
pp. 108431
Author(s):  
Nirvik Sen ◽  
K.K. Singh ◽  
S. Mukhopadhyay ◽  
K.T. Shenoy
Keyword(s):  
Solvent Free ◽  
Free Flow ◽  
Flow Synthesis

A Solvent-Free Base Liberation of a Tertiary Aminoalkyl Halide by Flow Chemistry

2016 ◽  
Vol 20 (12) ◽  
pp. 2043-2049 ◽  
Author(s):  
Michael J. Pedersen ◽  
Tommy Skovby ◽  
Michael J. Mealy ◽  
Kim Dam-Johansen ◽  
Søren Kiil
Keyword(s):  
Flow Chemistry ◽  
Solvent Free ◽  
Free Base

The free flow of ideas, information and materials

2000 ◽  
Vol 24 (6) ◽  
pp. iii-iii
Author(s):  
Natasha V. Raikhel ◽  
Mikio Nishimura ◽  
Ralph S. Quatrano ◽  
Stephen H. Howell ◽  
William Davies ◽  
...  
Keyword(s):  
Free Flow

Surfactant free synthesis of monodisperse styrenic nanoparticle colloids via flow chemistry

2020 ◽  
Author(s):  
Marta Antoniv ◽  
Shitong Zhu ◽  
Sehoon Chang ◽  
Nouf AlJabri
Keyword(s):  
Flow Chemistry

Purification of plasma membranes from leaves of conifer and deciduous tree species by phase partitioning and free-flow electrophoresis

1995 ◽  
Vol 95 (3) ◽  
pp. 399-408 ◽  
Author(s):  
Elena Toll ◽  
Federico J. Castillo ◽  
Pierre Crespi ◽  
Michele Crevecoeur ◽  
Hubert Greppin
Keyword(s):  
Tree Species ◽  
Plasma Membranes ◽  
Free Flow ◽  
Deciduous Tree ◽  
Phase Partitioning
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