Route Design to Manufacture: Synthesis of the Heterocyclic Fragment of AZD5718 Using a Non-cryogenic Lithiation-Alkoxycarbonylation Reaction

2021 ◽  
Vol 25 (4) ◽  
pp. 858-870
Author(s):  
Matthew Burns ◽  
Dave Perkins ◽  
Lai C. Chan ◽  
Michael J. Pilling ◽  
Anna Jawor-Baczynska ◽  
...  
Keyword(s):  
Heterocyclic Fragment ◽  
Route Design

The Synthesis of New Selenium-containing Heterocycles by the Oxidation Reaction of 2,4-Diaryltetrahydro-4H-selenochromenes

2020 ◽  
Vol 24 (15) ◽  
pp. 1663-1668
Author(s):  
Dmitriy Yurievich Direnko ◽  
Boris Ivanovich Drevko ◽  
Yaroslav Borisovich Drevko
Keyword(s):  
Nucleophilic Substitution ◽  
Chlorine Atom ◽  
Oxidation Reaction ◽  
Heterocyclic Fragment ◽  
Oxidative Aromatization

We have explored the reactions of tetrahydro-4H-selenochromenes in the presence of phosphoric pentachloride, and synthesized new condensate aroylbenzoselenophenes. During the reactions, tetrahydro-4H-selenochromenes with phosphoric pentachloride underwent oxidative aromatization and nucleophilic substitution for a chlorine atom of one of the protons in the alicyclic fragment. Also, the narrowing of the heterocyclic fragment occurred as in synthesized selenium-containing compounds earlier transformed into the corresponding condensate aroylbenzoselenophenes.

An efficient route design for solid waste collection using graph theory and the algorithm of the traveling agent in dynamic programming

2021 ◽  
Vol 193 (5) ◽  
Author(s):  
Moisés Filiberto Mora Murillo ◽  
Walter Alfredo Mora Murillo ◽  
Luis Xavier Orbea Hinojosa ◽  
Arlys Michel Lastre Aleaga ◽  
Gabriel Estuardo Cevallos Uve ◽  
...  
Keyword(s):  
Dynamic Programming ◽  
Graph Theory ◽  
Solid Waste ◽  
Waste Collection ◽  
Solid Waste Collection ◽  
Route Design ◽  
Efficient Route

ChemInform Abstract: 2,4-Dinitrophenol: A Novel Activating Reagent in Nucleotide Synthesis via the Phosphoramidite Route. Design of New Effective Phosphitylating Reagents.

ChemInform ◽  
2000 ◽  
Vol 31 (52) ◽  
pp. no-no
Author(s):  
Wojciech Dabkowski ◽  
Izabela Tworowska ◽  
Jan Michalski ◽  
Friedrich Cramer
Keyword(s):  
Nucleotide Synthesis ◽  
Route Design

Route design for community patrol by aircraft

2017 ◽  
Author(s):  
Da Liu ◽  
Houjun Yang
Keyword(s):  
Route Design

Regulatory Schemes on Public Transport

2017 ◽  
Vol 2649 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Vicente Huerta ◽  
Patricia Galilea
Keyword(s):  
Analytical Solutions ◽  
Private Initiative ◽  
Route Design ◽  
Innovative Solutions ◽  
Payment Schemes ◽  
Innovative Capabilities ◽  
Urban Bus ◽  
Open Question ◽  
Optimal Tariff

Regulatory schemes have remained an open question about the implementation of an urban bus system. Because of the introduction of a higher private initiative within these systems, the expectation of increased patronage has not been met. Hence, studying the effect of regulation on innovation becomes the first objective of this research because innovative solutions may help to attract users. To fulfill that objective, an analysis of innovative capabilities was carried out. The aim was to understand the gap between potential and practical innovation on the authorities and operators. The second objective was to use theoretical modeling to find the effect of payment schemes on frequency and bus size. Both analyses used as a case study the experience of Transantiago in Santiago, Chile. Innovation proved to be dependent on the regulatory scheme in which an operation was framed. Both authorities and operators showed the existence of innovative capabilities dependent on the perceived incentives. Trusting cooperation was an aspect that might have encouraged some types of innovation, such as route design. Analytical solutions showed that as in the experience of Transantiago, supply-based payments provided higher frequency and smaller bus size than fixed payments. Finally, an optimal tariff gave incentives to the operators to provide socially optimal levels of frequency and bus size for a certain demand level.

scholarly journals A Hybrid Ant Colony and Cuckoo Search Algorithm for Route Optimization of Heating Engineering

Energies ◽  
2018 ◽  
Vol 11 (10) ◽  
pp. 2675 ◽  
Author(s):  
Yang Zhang ◽  
Huihui Zhao ◽  
Yuming Cao ◽  
Qinhuo Liu ◽  
Zhanfeng Shen ◽  
...  
Keyword(s):  
Ant Colony Optimization ◽  
Optimization Algorithm ◽  
Search Algorithm ◽  
Fitness Function ◽  
Cuckoo Search ◽  
Cuckoo Search Algorithm ◽  
Ant Colony ◽  
Ant Colony Optimization Algorithm ◽  
Elapsed Time ◽  
Route Design

The development of remote sensing and intelligent algorithms create an opportunity to include ad hoc technology in the heating route design area. In this paper, classification maps and heating route planning regulations are introduced to create the fitness function. Modifications of ant colony optimization and the cuckoo search algorithm, as well as a hybridization of the two algorithms, are proposed to solve the specific Zhuozhou–Fangshan heating route design. Compared to the fitness function value of the manual route (234.300), the best route selected by modified ant colony optimization (ACO) was 232.343, and the elapsed time for one solution was approximately 1.93 ms. Meanwhile, the best route selected by modified Cuckoo Search (CS) was 244.247, and the elapsed time for one solution was approximately 0.794 ms. The modified ant colony optimization algorithm can find the route with smaller fitness function value, while the modified cuckoo search algorithm can find the route overlapped to the manual selected route better. The modified cuckoo search algorithm runs more quickly but easily sticks into the premature convergence. Additionally, the best route selected by the hybrid ant colony and cuckoo search algorithm is the same as the modified ant colony optimization algorithm (232.343), but with higher efficiency and better stability.

scholarly journals Problems of Designing Transport Systems of «siberian Antrazit»

2021 ◽  
Author(s):  
Natalia Gorbunova ◽  
Oleg Mirkushov
Keyword(s):  
Bellman Equation ◽  
Railway Track ◽  
Open Pit ◽  
Motor Vehicles ◽  
Transport Systems ◽  
Dynamic Programming Method ◽  
Optimal Route ◽  
Open Pit Mines ◽  
Route Design ◽  
Delivery Route

Abstract The main aim of this work was to identify an optimal route design for the delivery of coal from the open pit mines to the enrichment plants on the example of the Sibathractic Group’s mine “Kolyvansk” and its enrichment plants «Listvjanskaja-1» and «Listvjanskaja-2». The new route would allow the corporation to increase production rates and to reduce the risks associated with the use of motor vehicles. Dynamic programming method, mainly the Bellman equation principle, was chosen as an algorithm for searching for the optimal route from Kolyvansky mine to the «Listvjanskaja-1» and «Listvjanskaja-2». In the course of the study the two possible routes were selected. Further comparison indicated that only one of them - “2nd railway track”, corresponded to all the recommended parameters for the delivery route. All the findings are presented in detail in the study.

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