Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis

2020 ◽  
Vol 24 (11) ◽  
pp. 2453-2461 ◽  
Author(s):  
Feng Peng ◽  
Guy R. Humphrey ◽  
Kevin M. Maloney ◽  
Dan Lehnherr ◽  
Mark Weisel ◽  
...  
Keyword(s):  
Manufacturing Process ◽  
Sustainable Manufacturing ◽  
Phenol Synthesis ◽  
Robust Process

scholarly journals A Review of Engineering Research in Sustainable Manufacturing

2013 ◽  
Vol 135 (4) ◽  
Author(s):  
Karl R. Haapala ◽  
Fu Zhao ◽  
Jaime Camelio ◽  
John W. Sutherland ◽  
Steven J. Skerlos ◽  
...  
Keyword(s):  
Decision Making ◽  
Manufacturing Process ◽  
Manufacturing Systems ◽  
Sustainable Manufacturing ◽  
Supply Chain Design ◽  
Planning And Scheduling ◽  
Engineering Research ◽  
Challenges And Opportunities ◽  
Recent Developments ◽  
Planning Development

Sustainable manufacturing requires simultaneous consideration of economic, environmental, and social implications associated with the production and delivery of goods. Fundamentally, sustainable manufacturing relies on descriptive metrics, advanced decision-making, and public policy for implementation, evaluation, and feedback. In this paper, recent research into concepts, methods, and tools for sustainable manufacturing is explored. At the manufacturing process level, engineering research has addressed issues related to planning, development, analysis, and improvement of processes. At a manufacturing systems level, engineering research has addressed challenges relating to facility operation, production planning and scheduling, and supply chain design. Though economically vital, manufacturing processes and systems have retained the negative image of being inefficient, polluting, and dangerous. Industrial and academic researchers are re-imagining manufacturing as a source of innovation to meet society's future needs by undertaking strategic activities focused on sustainable processes and systems. Despite recent developments in decision making and process- and systems-level research, many challenges and opportunities remain. Several of these challenges relevant to manufacturing process and system research, development, implementation, and education are highlighted.

Challenges in Sustainable Manufacturing With Industrial and Collaborative Robots: A Case Study

2018 ◽  
Author(s):  
Romain Farel ◽  
Selma Kchir ◽  
Xavier Lamy ◽  
Mathieu Grossard
Keyword(s):  
Manufacturing Process ◽  
Return On Investment ◽  
Industrial Robot ◽  
Sustainable Manufacturing ◽  
Programming By Demonstration ◽  
End User ◽  
Manual Work ◽  
Considerable Cost ◽  
Collaborative Robot

Automation of manufacturing process with robots is an industrial challenge, generally evaluated by the Return On Investment (ROI) that such a transformation could generate. However, the automation has a considerable cost particularly for SMEs, which makes a barrier to access and limits the motivation of facilitating the manual work of the operators, despite of nonergonomic and risky situations. In this study, supported by the European project HORSE, we went through the development of a robotic solution to assist the operator in the manufacturing. This component called programming-by-demonstration is integrated in both main categories of automation: industrial robot and collaborative robot (cobot). Both applications are tested and evaluated in a real manufacturing task (cutting cast pieces from foundry) and evaluated by the industrial end-user. The paper states on the application of the developed component, and concludes with the lesson learned.

Tacit Knowledge Reuse in a Next Generation Sustainable Manufacturing Process

2015 ◽  
Author(s):  
David A. Guerra-Zubiaga ◽  
Drew Heiling ◽  
Olusola Onadipe ◽  
Rojan-Kumar Katuwal ◽  
Prabin Dhital ◽  
...  
Keyword(s):  
Tacit Knowledge ◽  
Manufacturing Process ◽  
Manufacturing Systems ◽  
Sustainable Manufacturing ◽  
Intangible Asset ◽  
Next Generation ◽  
Knowledge Modeling ◽  
Relevant Concept ◽  
Manufacturing Enterprises ◽  
Factory Of The Future

Tacit knowledge is a very important intangible asset at manufacturing enterprises and Next Generation Manufacturing Systems (NGMS) is a relevant concept to understand manufacturing paradigms. Some Manufacturing paradigms are Factory of the future (FoF) in a Sustainable Manufacturing environment. There is a need not only to create approaches to understands the NGMS addressing the FoF to support Sustainable Manufacture, but also to capture the key manufacturing tacit knowledge through this process. This paper presents a novel idea about tacit knowledge modeling and reuse in a sustainable manufacturing application.

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