Distinct Morphological Transitions of Photoreactive and Thermoresponsive Vesicles for Controlled Release and Nanoreactors

2016 ◽  
Vol 49 (21) ◽  
pp. 8282-8295 ◽  
Author(s):  
Chenzhi Yao ◽  
Xiaorui Wang ◽  
Guhuan Liu ◽  
Jinming Hu ◽  
Shiyong Liu
Keyword(s):  
Controlled Release ◽  
Morphological Transitions

scholarly journals Morphological Transitions of Photoresponsive Vesicles from Amphiphilic Polypeptoid Copolymers for Controlled Release

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 798
Author(s):  
Xu Yang ◽  
Zhiwei Wang ◽  
Jing Sun
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Uv Irradiation ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Poly Ethylene Glycol ◽  
Morphological Transitions ◽  
Poly Ethylene ◽  
Copolymer Poly

Photoresponsive polymers have attracted increasing interest for a variety of applications. Here, we report a family of photoresponsive polypeptoid-based copolymer poly(ethylene glycol)-b-poly(N-(S-(o-nitrobenzyl)-thioethyl) glycine)-co-poly(N-(2-phenylethyl) glycine) (PEG-b-PNSN-co-PNPE) synthesized by the controlled ring-opening polymerization (ROP) technique. The key feature of the design is to incorporate both o-nitrobenzyl group moiety to offer the photoresponsive property and phenethyl residues to tune the structural and amphiphilic property of the system. We demonstrate that the cleavage degree of the o-nitrobenzyl group can reach to 100% upon UV-irradiation. With delicate design, a photoresponsive vesicle-to-sphere transition has been observed that facilitates the release of the encapsulants. This work provides a facile approach to prepare a type of photoresponsive polymers with tunable properties for drug delivery.

Controlled release antibiotics for dry powder lung delivery

2009 ◽  
Vol 00 (00) ◽  
pp. 090805050810080-8 ◽  
Author(s):  
Handoko Adi ◽  
Paul Michael Young ◽  
Hak-Kim Chan ◽  
Rania Salama ◽  
Daniela Traini
Keyword(s):  
Controlled Release ◽  
Dry Powder ◽  
Lung Delivery

Controlled Release of Metformin Hydrochloride I. In vitro Release from Physical Mixture Containing Xanthan Gum as Hydrophilic Rate Retarding Polymer

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Mashkura Ashrafi ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
In Vitro Release ◽  
Correlation Coefficients ◽  
High Ratio ◽  
Water Soluble ◽  
Metformin Hydrochloride ◽  
Model Drug ◽  
Very High

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size ‘1’. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

Controlled-Release Products for the Control of the Estrus Cycle in Cattle, Sheep, Goats, Deer, Pigs, and Horses

1998 ◽  
Vol 15 (4) ◽  
pp. 96 ◽  
Author(s):  
Michael J. Rathbone ◽  
Keith L Macmillan ◽  
Wolfgang Jochle ◽  
Maurice P. Boland ◽  
E. Keith Inskeep
Keyword(s):  
Controlled Release ◽  
Estrus Cycle

Controlled Release of Insulin Granules from PLGA Microparticles for Glucose Modulation in Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2279-PUB ◽  
Author(s):  
ROSITA PRIMAVERA ◽  
MIRKO MAGNONE ◽  
DANIELE DI MASCOLO ◽  
ELENA ZOCCHI ◽  
ANGELO DE PASCALE ◽  
...  
Keyword(s):  
Controlled Release ◽  
Insulin Granules ◽  
Plga Microparticles
Sign in / Sign up

Export Citation Format

Share Document